{"id":"https://openalex.org/W4205387735","doi":"https://doi.org/10.1109/bibm52615.2021.9669899","title":"Improved Multi-task SCCA for Brain Imaging Genetics via Joint Consideration of the Diagnosis, Parameter Decomposition and Network Constraints","display_name":"Improved Multi-task SCCA for Brain Imaging Genetics via Joint Consideration of the Diagnosis, Parameter Decomposition and Network Constraints","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4205387735","doi":"https://doi.org/10.1109/bibm52615.2021.9669899"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669899","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669899","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100327355","display_name":"Xin Zhang","orcid":"https://orcid.org/0000-0001-7900-4984"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhang","raw_affiliation_strings":["Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000325560","display_name":"Yipeng Hao","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yipeng Hao","raw_affiliation_strings":["Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100735527","display_name":"Jin Zhang","orcid":"https://orcid.org/0000-0001-9001-1931"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["School of Automation, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","School of Automation, Northwestern Polytechnical University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043827391","display_name":"Shihong Zou","orcid":"https://orcid.org/0000-0001-9730-2918"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shihong Zou","raw_affiliation_strings":["Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101957624","display_name":"Songyun Xie","orcid":"https://orcid.org/0000-0002-8774-7291"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songyun Xie","raw_affiliation_strings":["School of Electronics and Information, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","School of Electronics and Information, Northwestern Polytechnical University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronics and Information, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Electronics and Information, Northwestern Polytechnical University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038203074","display_name":"Lei Du","orcid":"https://orcid.org/0000-0002-6698-9814"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Du","raw_affiliation_strings":["School of Automation, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","School of Automation, Northwestern Polytechnical University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University, Xi\u2019an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.504,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54545455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1159","last_page":"1164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imaging-genetics","display_name":"Imaging genetics","score":0.8672198057174683},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.814106822013855},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7039345502853394},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.612993597984314},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5157473683357239},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.47538578510284424},{"id":"https://openalex.org/keywords/canonical-correlation","display_name":"Canonical correlation","score":0.4480474889278412},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4458511471748352},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4312269687652588},{"id":"https://openalex.org/keywords/alzheimers-disease-neuroimaging-initiative","display_name":"Alzheimer's Disease Neuroimaging Initiative","score":0.4255562722682953},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.41068726778030396},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.18519726395606995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1685723066329956},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.1669462025165558},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11500203609466553}],"concepts":[{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.8672198057174683},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.814106822013855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7039345502853394},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.612993597984314},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5157473683357239},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.47538578510284424},{"id":"https://openalex.org/C153874254","wikidata":"https://www.wikidata.org/wiki/Q115542","display_name":"Canonical correlation","level":2,"score":0.4480474889278412},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4458511471748352},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4312269687652588},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.4255562722682953},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.41068726778030396},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18519726395606995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1685723066329956},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1669462025165558},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11500203609466553},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669899","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669899","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5299999713897705,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W421681547","https://openalex.org/W2037603765","https://openalex.org/W2065131965","https://openalex.org/W2112658198","https://openalex.org/W2138001941","https://openalex.org/W2155277084","https://openalex.org/W2166348468","https://openalex.org/W2220386886","https://openalex.org/W2607528709","https://openalex.org/W2618297622","https://openalex.org/W2777005960","https://openalex.org/W2786073924","https://openalex.org/W2898262363","https://openalex.org/W2911502764","https://openalex.org/W2961886995","https://openalex.org/W2962898942","https://openalex.org/W2963510247","https://openalex.org/W2979903847","https://openalex.org/W2981153408","https://openalex.org/W2982638646","https://openalex.org/W3026137507","https://openalex.org/W3043467106","https://openalex.org/W6768743507"],"related_works":["https://openalex.org/W2755450364","https://openalex.org/W1628671467","https://openalex.org/W2483130478","https://openalex.org/W336817979","https://openalex.org/W2016777699","https://openalex.org/W2013450123","https://openalex.org/W3112573618","https://openalex.org/W2031131415","https://openalex.org/W2980858150","https://openalex.org/W2113580908"],"abstract_inverted_index":{"Brain":[0],"imaging":[1,85,109,135,158,184,218],"genetics":[2],"develops":[3],"rapidly,":[4],"aiming":[5],"to":[6,78,106,216],"identify":[7,79,130],"bi-multivariate":[8],"associations":[9],"between":[10,82],"genetic":[11,83,119,141,219],"loci":[12],"and":[13,28,60,84,133,137,168,180],"neuroimaging":[14,65,197],"quantitative":[15],"traits":[16],"(QTs).":[17],"The":[18],"multi-task":[19,169],"Sparse":[20],"Canonical":[21],"Correlation":[22],"Analysis":[23],"(MTSCCA)":[24],"is":[25],"a":[26,73,114,147,182,213],"popular":[27],"effective":[29],"technique":[30],"in":[31],"this":[32,69],"area":[33],"since":[34],"it":[35,94,105,210],"obtains":[36,181],"superior":[37],"results":[38,192],"than":[39],"those":[40],"single-task":[41,167],"based":[42],"SCCA":[43,163],"methods.":[44],"Unfortunately,":[45],"the":[46,58,80,96,125,171,194],"most":[47],"existing":[48],"MTSCCA":[49,77],"methods":[50,164],"are":[51],"either":[52],"unsupervised":[53],"or":[54,176],"incapable":[55],"of":[56,63,100,118,186],"identifying":[57],"shared":[59],"specific":[61],"patterns":[62],"multimodal":[64,108],"QTs":[66,110],"simultaneously.":[67],"In":[68,189],"paper,":[70],"we":[71,144],"propose":[72],"novel":[74],"diagnosis":[75],"guided":[76],"association":[81],"phenotypic":[86],"markers.":[87],"Our":[88],"method":[89,123,173,204],"has":[90,174],"three":[91],"merits.":[92],"First,":[93],"follows":[95],"same":[97],"modeling":[98],"paradigm":[99],"previous":[101],"MTSCCA.":[102],"This":[103],"enables":[104],"incorporate":[107],"jointly,":[111],"thereby":[112],"facilitating":[113],"more":[115],"comprehensive":[116],"identification":[117],"factors.":[120],"Second,":[121],"our":[122,203],"utilizes":[124],"parameter":[126],"decomposition":[127],"which":[128,151],"could":[129,152,211],"both":[131,166],"modality-shared":[132],"-specific":[134],"QTs,":[136],"further":[138],"uncovers":[139],"their":[140],"mechanisms.":[142],"Third,":[143],"also":[145],"employed":[146],"new":[148],"network":[149],"constraint":[150],"find":[153],"out":[154],"potentially":[155],"meaningful":[156,206],"brain":[157,217],"networks.":[159],"Compared":[160],"with":[161],"conventional":[162],"including":[165],"ones,":[170],"proposed":[172],"improved":[175],"comparable":[177],"correlation":[178],"coefficients,":[179],"clean":[183],"pattern":[185],"good":[187],"meaning.":[188],"addition,":[190],"these":[191],"on":[193],"Alzheimer\u2019s":[195],"disease":[196],"initiative":[198],"(ADNI)":[199],"cohort":[200],"show":[201],"that":[202,209],"selects":[205],"biomarkers,":[207],"indicating":[208],"offer":[212],"significant":[214],"addition":[215],"studies.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}