{"id":"https://openalex.org/W4205497854","doi":"https://doi.org/10.1109/bibm52615.2021.9669808","title":"Gene expression analysis of known COPD loci revealed its varied levels by disease severity","display_name":"Gene expression analysis of known COPD loci revealed its varied levels by disease severity","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4205497854","doi":"https://doi.org/10.1109/bibm52615.2021.9669808"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669808","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669808","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068876656","display_name":"Geumkyung Nah","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Geumkyung Nah","raw_affiliation_strings":["Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103867536","display_name":"Eun-A Choi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-A Choi","raw_affiliation_strings":["Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108003497","display_name":"JW Kim","orcid":"https://orcid.org/0000-0002-0498-5762"},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiwon Kim","raw_affiliation_strings":["Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Woojin Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109191","display_name":"Kangwon National University Hospital","ror":"https://ror.org/01rf1rj96","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210109191"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woojin Kim","raw_affiliation_strings":["Depart of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University Hospital, Kangwon National University, Chuncheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depart of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University Hospital, Kangwon National University, Chuncheon, Korea","institution_ids":["https://openalex.org/I4210109191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033517259","display_name":"Kwang Ha Yoo","orcid":"https://orcid.org/0000-0001-9969-2657"},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwangha Yoo","raw_affiliation_strings":["Department of Internal Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Konkuk University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Konkuk University, Seoul, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078021771","display_name":"Young-Youl Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Youl Kim","raw_affiliation_strings":["Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054310571","display_name":"Dankyu Yoon","orcid":"https://orcid.org/0000-0003-3409-2399"},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dankyu Yoon","raw_affiliation_strings":["Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chronic Disease Convergence Research, Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1673","last_page":"1675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9674000144004822,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.9616000056266785,"subfield":{"id":"https://openalex.org/subfields/3604","display_name":"Emergency Medical Services"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copd","display_name":"COPD","score":0.9639725685119629},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.8202904462814331},{"id":"https://openalex.org/keywords/pulmonary-disease","display_name":"Pulmonary disease","score":0.6715483665466309},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.654101550579071},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5444610118865967},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5142313838005066},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4990215301513672},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.43968838453292847},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3669498860836029},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35138148069381714},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3448798656463623},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3316953480243683},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26965606212615967}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.9639725685119629},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8202904462814331},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.6715483665466309},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.654101550579071},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5444610118865967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5142313838005066},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4990215301513672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43968838453292847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3669498860836029},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35138148069381714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3448798656463623},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3316953480243683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26965606212615967},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669808","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669808","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320318372","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2161633633","https://openalex.org/W2164563303","https://openalex.org/W2510973425","https://openalex.org/W2529241974","https://openalex.org/W2901303766","https://openalex.org/W2951090934","https://openalex.org/W3008726958","https://openalex.org/W3097242660","https://openalex.org/W3215210255","https://openalex.org/W4291674955"],"related_works":["https://openalex.org/W2044433330","https://openalex.org/W2372297656","https://openalex.org/W3001106132","https://openalex.org/W2321909504","https://openalex.org/W349070009","https://openalex.org/W2335327079","https://openalex.org/W2364717413","https://openalex.org/W2391752226","https://openalex.org/W2091986469","https://openalex.org/W4376601739"],"abstract_inverted_index":{"Numerous":[0],"genome":[1],"studies":[2],"on":[3],"chronic":[4],"obstructive":[5],"pulmonary":[6],"disease":[7,28],"(COPD)":[8],"have":[9],"revealed":[10],"hundreds":[11],"of":[12,17,23,41,55,73,116],"associated":[13],"loci.":[14,104],"However,":[15],"understanding":[16,115],"COPD":[18,43,50,67,74,99,103,117],"pathogenesis":[19],"in":[20,84],"the":[21],"context":[22],"biological":[24],"pathway,":[25],"especially":[26],"for":[27],"severity,":[29,119],"has":[30],"remained":[31],"unclear.":[32],"In":[33],"this":[34,91],"study,":[35],"we":[36],"studied":[37],"gene":[38,80,95],"expression":[39,53,81,96],"patterns":[40],"known":[42,57,102],"loci":[44],"among":[45,101],"mild,":[46],"moderate,":[47],"and":[48,120],"severe":[49,87],"patients.":[51],"Although":[52],"levels":[54,72],"16":[56],"genes":[58],"available":[59],"from":[60],"RNA-seq":[61],"were":[62],"not":[63],"significantly":[64],"different":[65,94],"across":[66],"severity":[68,75,100],"by":[69,98],"comparing":[70],"varied":[71],"$(\\mathrm{P}\\gt0.05)$,":[76],"DIP2B":[77],"showed":[78],"higher":[79],"mean":[82],"changes":[83,97],"mild":[85],"than":[86],"group.":[88],"Taken":[89],"together,":[90],"study":[92],"demonstrated":[93],"The":[105],"results":[106],"will":[107],"be":[108],"valuable":[109],"scientific":[110],"evidence":[111],"to":[112],"enhance":[113],"our":[114],"risk,":[118],"related":[121],"pathogenesis.":[122]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}