{"id":"https://openalex.org/W4206809068","doi":"https://doi.org/10.1109/bibm52615.2021.9669627","title":"Study on Traditional Chinese Medicine in the Treatment of Knee Osteoarthritis Based on Data Mining of Ancient Medical Classics","display_name":"Study on Traditional Chinese Medicine in the Treatment of Knee Osteoarthritis Based on Data Mining of Ancient Medical Classics","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4206809068","doi":"https://doi.org/10.1109/bibm52615.2021.9669627"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669627","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669627","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100611808","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0001-7534-3647"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033527896","display_name":"Xinfeng Guo","orcid":"https://orcid.org/0000-0003-2699-9740"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinfeng Guo","raw_affiliation_strings":["Guangdong Province Traditional, Chinese Medical Hospital, Guangzhou, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Province Traditional, Chinese Medical Hospital, Guangzhou, P.R.China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049081910","display_name":"Shuo Yang","orcid":"https://orcid.org/0000-0001-6914-6604"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuo Yang","raw_affiliation_strings":["Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085963057","display_name":"Sihong Liu","orcid":"https://orcid.org/0000-0002-5188-5334"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sihong Liu","raw_affiliation_strings":["Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340769","display_name":"Hongtao Li","orcid":"https://orcid.org/0000-0001-6366-0741"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongtao Li","raw_affiliation_strings":["Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060779945","display_name":"Guangkun Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangkun Chen","raw_affiliation_strings":["Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035916847","display_name":"Hongjie Gao","orcid":"https://orcid.org/0000-0001-5239-8338"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjie Gao","raw_affiliation_strings":["Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492003","display_name":"Huamin Zhang","orcid":"https://orcid.org/0000-0002-7210-9203"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huamin Zhang","raw_affiliation_strings":["Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007036736","display_name":"Lin Tong","orcid":"https://orcid.org/0000-0002-0845-2496"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Tong","raw_affiliation_strings":["Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R.China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61842105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3919","last_page":"3926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9840999841690063,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9664000272750854,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.8058837056159973},{"id":"https://openalex.org/keywords/radix","display_name":"Radix (gastropod)","score":0.7559925317764282},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7420181035995483},{"id":"https://openalex.org/keywords/decoction","display_name":"Decoction","score":0.7013899683952332},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.6169520616531372},{"id":"https://openalex.org/keywords/angelica-sinensis","display_name":"Angelica sinensis","score":0.530245304107666},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"Alternative medicine","score":0.21697372198104858},{"id":"https://openalex.org/keywords/botany","display_name":"Botany","score":0.06213301420211792}],"concepts":[{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.8058837056159973},{"id":"https://openalex.org/C2779091547","wikidata":"https://www.wikidata.org/wiki/Q287565","display_name":"Radix (gastropod)","level":2,"score":0.7559925317764282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7420181035995483},{"id":"https://openalex.org/C190409667","wikidata":"https://www.wikidata.org/wiki/Q1136912","display_name":"Decoction","level":2,"score":0.7013899683952332},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.6169520616531372},{"id":"https://openalex.org/C2779454681","wikidata":"https://www.wikidata.org/wiki/Q2051387","display_name":"Angelica sinensis","level":4,"score":0.530245304107666},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.21697372198104858},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.06213301420211792},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669627","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669627","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4300000071525574,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334111","display_name":"Innovation Fund","ror":null},{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1547613640","https://openalex.org/W1967127210","https://openalex.org/W1990817938","https://openalex.org/W2028469883","https://openalex.org/W2154461664","https://openalex.org/W2161256419","https://openalex.org/W2170800831","https://openalex.org/W2179325826","https://openalex.org/W2270743897","https://openalex.org/W2377387911","https://openalex.org/W2379658865","https://openalex.org/W2795547095","https://openalex.org/W2905782592","https://openalex.org/W2917787580","https://openalex.org/W2923515411","https://openalex.org/W3043327164","https://openalex.org/W3206071067","https://openalex.org/W4211069396","https://openalex.org/W4253122845","https://openalex.org/W6682885887","https://openalex.org/W6709183505"],"related_works":["https://openalex.org/W4242734389","https://openalex.org/W2901349768","https://openalex.org/W2374076642","https://openalex.org/W2354283719","https://openalex.org/W2364237395","https://openalex.org/W2050575529","https://openalex.org/W2389885244","https://openalex.org/W1983892203","https://openalex.org/W2040347630","https://openalex.org/W2920328542"],"abstract_inverted_index":{"Objective":[0],"The":[1,38,109,138,185],"prescription":[2],"rules":[3],"of":[4,40,61,75,84,105,180,204,209],"traditional":[5],"Chinese":[6,22],"medicine":[7],"(TCM)":[8],"for":[9,33,43,189,237],"knee":[10],"osteoarthritis":[11],"(KOA)":[12],"in":[13,45,55],"ancient":[14,46,90],"medical":[15,47,91],"classics":[16,48],"were":[17,49,79,87,114,143],"explored":[18],"based":[19],"on":[20],"Traditional":[21],"Medicine":[23],"Inheritance":[24],"Computer":[25],"System":[26],"(TCMICS)":[27],"to":[28],"provide":[29,235],"reference":[30,236],"and":[31,52,64,72,99,129,135,162,197,213,217,222,226,230],"evidence":[32],"modern":[34],"clinical":[35,238],"treatment.":[36,239],"Methods":[37],"contents":[39],"TCM":[41],"treatment":[42],"KOA":[44,190],"comprehensively":[50],"collected":[51],"then":[53],"logged":[54],"TCMICS":[56],"after":[57],"screening,":[58],"where":[59],"frequency":[60,104],"formulae,":[62],"medicinals":[63,101,141,205],"medicinal":[65],"combination,":[66],"as":[67,69],"well":[68],"properties,":[70],"flavors":[71],"channel":[73],"tropism":[74],"frequently-used":[76],"medicinals,":[77],"etc.":[78],"counted.":[80],"Results":[81],"A":[82],"total":[83],"510":[85],"items":[86],"selected":[88],"from":[89],"classics,":[92],"including":[93],"221":[94],"formulae":[95,112,187],"with":[96,102],"specific":[97],"names,":[98],"25":[100],"a":[103],"more":[106],"than":[107],"40.":[108],"top":[110,139],"three":[111],"which":[113,142,233],"most":[115,144],"frequently":[116,145],"used":[117,146,188],"included":[118,147],"Da":[119,181,192],"Fangfeng":[120,156,182,193],"Tang":[121,126,132],"(Major":[122],"Ledebouriella":[123],"Decoction),":[124,128],"Wutou":[125,195],"(Aconite":[127],"Duhuo":[130,198],"Jisheng":[131,199],"(Pubescent":[133],"Angelica":[134],"Mistletoe":[136],"Decoction).":[137],"five":[140],"Danggui":[148],"(Angelicae":[149],"Sinensis":[150],"Radix),":[151,155,158],"Niuxi":[152],"(Achyranthis":[153],"Bidentatae":[154],"(Saposhnikoviae":[157],"Chuanxiong":[159],"(Chuanxiong":[160],"Rhizoma),":[161],"Gancao":[163],"(Glycyrrhizae":[164],"Radix":[165],"et":[166],"Rhizoma).":[167],"It":[168],"was":[169,178],"also":[170],"found":[171],"through":[172],"analysis":[173],"that":[174],"the":[175,202,207,211,228],"core":[176],"formula":[177],"modification":[179],"Tang.":[183],"Conclusion":[184],"main":[186],"are":[191],"Tang,":[194,196,200],"while":[201],"selection":[203],"highlights":[206],"actions":[208],"nourishing":[210],"liver":[212],"kidney,":[214],"boosting":[215],"qi":[216],"blood,":[218],"or":[219],"activating":[220],"blood":[221,224],"removing":[223],"stasis,":[225],"warming":[227],"channels":[229],"dissipating":[231],"cold,":[232],"can":[234]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}