{"id":"https://openalex.org/W4206358472","doi":"https://doi.org/10.1109/bibm52615.2021.9669501","title":"Repositioning Traditional Chinese Medicine to PI3K Pathway Proteins Based on Deep Learning Method","display_name":"Repositioning Traditional Chinese Medicine to PI3K Pathway Proteins Based on Deep Learning Method","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4206358472","doi":"https://doi.org/10.1109/bibm52615.2021.9669501"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669501","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669501","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101422287","display_name":"Yue Zhong","orcid":"https://orcid.org/0000-0001-5826-0110"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhong","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333854","display_name":"Xun Wang","orcid":"https://orcid.org/0000-0002-2741-433X"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Wang","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048824934","display_name":"Qingyu Tian","orcid":"https://orcid.org/0000-0003-2259-2003"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyu Tian","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101789308","display_name":"Dayan Liu","orcid":"https://orcid.org/0000-0001-9932-2947"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dayan Liu","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386112","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0002-2960-425X"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019435645","display_name":"Huanhuan Dai","orcid":"https://orcid.org/0000-0002-6331-8038"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanhuan Dai","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108065010","display_name":"Gan Wang","orcid":"https://orcid.org/0000-0003-3199-6309"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gan Wang","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100441863","display_name":"Xudong Zhang","orcid":"https://orcid.org/0000-0003-2671-8275"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudong Zhang","raw_affiliation_strings":["College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, China University of Petroleum(East China), Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162190"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24221453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":null,"first_page":"3957","last_page":"3962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.9807000160217285,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.7193173766136169},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6271960139274597},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6226881146430969},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.55643230676651},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47380489110946655},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.42138487100601196},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41019758582115173},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3022635579109192},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.23942524194717407},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20124539732933044},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17195665836334229},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0960264503955841}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7193173766136169},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6271960139274597},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6226881146430969},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.55643230676651},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47380489110946655},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.42138487100601196},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41019758582115173},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3022635579109192},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23942524194717407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20124539732933044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17195665836334229},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0960264503955841},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669501","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669501","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320337495","display_name":"Technology Development","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1911359970","https://openalex.org/W2004944892","https://openalex.org/W2035585923","https://openalex.org/W2109991441","https://openalex.org/W2194775991","https://openalex.org/W2303251554","https://openalex.org/W2325498754","https://openalex.org/W2335367194","https://openalex.org/W2397818397","https://openalex.org/W2605952223","https://openalex.org/W2765232158","https://openalex.org/W2785947426","https://openalex.org/W2888013532","https://openalex.org/W2964667563","https://openalex.org/W3016208404","https://openalex.org/W3021247069","https://openalex.org/W3035783911","https://openalex.org/W3082062688","https://openalex.org/W3125890999","https://openalex.org/W4230270846","https://openalex.org/W4231435929","https://openalex.org/W4249158993","https://openalex.org/W4252952175","https://openalex.org/W4253590319","https://openalex.org/W6640266074"],"related_works":["https://openalex.org/W4394753513","https://openalex.org/W1006589974","https://openalex.org/W1974250949","https://openalex.org/W2031281657","https://openalex.org/W4226493464","https://openalex.org/W4312417841","https://openalex.org/W3133861977","https://openalex.org/W2951211570","https://openalex.org/W3103566983","https://openalex.org/W3029198973"],"abstract_inverted_index":{"Traditional":[0],"Chinese":[1,18],"medicines":[2],"(TCMs)":[3],"have":[4,145],"been":[5],"used":[6],"to":[7,39,65,72,94],"treat":[8],"diseases":[9],"for":[10,23],"thousands":[11],"of":[12,16,26,69,75,98,116,121,130,153],"years.":[13],"The":[14,114],"application":[15,52],"traditional":[17],"medicine":[19],"provides":[20,49],"new":[21],"ideas":[22],"the":[24,67,85,96,118],"treatment":[25],"cancer":[27,99],"and":[28,58,77,83,109,143],"other":[29],"intractable":[30],"diseases.":[31],"Phosphoinositide-3kinase":[32],"(PI3K)":[33],"pathway":[34,136,155],"is":[35,107,124],"an":[36],"important":[37],"way":[38],"regulate":[40,89],"tumor":[41],"cells,":[42],"such":[43],"as":[44,93],"cervical":[45],"cancer.":[46],"Deep":[47],"learning":[48,71],"a":[50],"powerful":[51],"in":[53],"calculating":[54],"interactions":[55],"between":[56],"drugs":[57],"targets.":[59,156,167],"In":[60],"this":[61],"study,":[62],"we":[63],"try":[64],"use":[66],"method":[68],"deep":[70,102],"reposition":[73],"molecules":[74,129],"TCMs":[76,86,132],"21":[78,134],"targets":[79],"on":[80,111,165],"PI3K":[81,90,135,154],"pathway,":[82,91],"predict":[84],"that":[87,141],"can":[88],"so":[92],"achieve":[95],"purpose":[97],"treatment.":[100],"A":[101],"convolutional":[103],"neural":[104],"network":[105],"(DCNN)":[106],"constructed":[108],"trained":[110],"KIBA":[112],"dataset.":[113],"accuracy":[115],"predicting":[117],"binding":[119,147],"affinity":[120,148],"drug-target":[122],"pairs":[123],"85.3%.":[125],"DCNN":[126],"ranked":[127],"433":[128],"35":[131],"with":[133,149],"target":[137],"proteins.":[138],"We":[139],"find":[140],"Gancao":[142],"Huangqin":[144],"strong":[146],"more":[150],"than":[151],"half":[152],"Meanwhile,":[157],"Renshen,":[158],"Zhizi,":[159],"Mahuang,":[160],"etc.":[161],"are":[162],"also":[163],"effective":[164],"multiple":[166]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
