{"id":"https://openalex.org/W4205590955","doi":"https://doi.org/10.1109/bibm52615.2021.9669493","title":"Discover the Binding Domain of Transmembrane Proteins Based on Structural Universality","display_name":"Discover the Binding Domain of Transmembrane Proteins Based on Structural Universality","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4205590955","doi":"https://doi.org/10.1109/bibm52615.2021.9669493"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669493","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669493","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004423488","display_name":"Yihang Bao","orcid":"https://orcid.org/0000-0002-8431-3412"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yihang Bao","raw_affiliation_strings":["School of Information Science and Technology, Northeast Normal University Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northeast Normal University Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029320742","display_name":"Weixi Wang","orcid":"https://orcid.org/0009-0004-9869-0149"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Weixi Wang","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025175379","display_name":"Minglong Dong","orcid":"https://orcid.org/0000-0002-7100-6878"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minglong Dong","raw_affiliation_strings":["School of Information Science and Technology, Northeast Normal University Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northeast Normal University Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087149818","display_name":"Fei He","orcid":"https://orcid.org/0000-0002-3284-9506"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei He","raw_affiliation_strings":["School of Information Science and Technology, Northeast Normal University Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northeast Normal University Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University Changchun, China","institution_ids":["https://openalex.org/I184983240","https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100452641","display_name":"Han Wang","orcid":"https://orcid.org/0000-0001-5448-9903"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Wang","raw_affiliation_strings":["School of Information Science and Technology, Northeast Normal University Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Northeast Normal University Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"5","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/universality","display_name":"Universality (dynamical systems)","score":0.8085674047470093},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.6197645664215088},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.49937963485717773},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4736020565032959},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.4705427289009094},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4233844578266144},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.4134727716445923},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3732353448867798},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.32145023345947266},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.23925957083702087},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1550033688545227},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.137254536151886},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1365029215812683},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12592735886573792},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.10806602239608765}],"concepts":[{"id":"https://openalex.org/C183992945","wikidata":"https://www.wikidata.org/wiki/Q2495574","display_name":"Universality (dynamical systems)","level":2,"score":0.8085674047470093},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6197645664215088},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.49937963485717773},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4736020565032959},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4705427289009094},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4233844578266144},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4134727716445923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3732353448867798},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32145023345947266},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23925957083702087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1550033688545227},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.137254536151886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1365029215812683},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12592735886573792},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10806602239608765},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669493","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669493","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.49000000953674316,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1786434256","https://openalex.org/W1968682237","https://openalex.org/W1968921383","https://openalex.org/W1971074050","https://openalex.org/W2007624258","https://openalex.org/W2011402521","https://openalex.org/W2021639324","https://openalex.org/W2062088852","https://openalex.org/W2068351024","https://openalex.org/W2074019887","https://openalex.org/W2074772891","https://openalex.org/W2096864392","https://openalex.org/W2105537627","https://openalex.org/W2107706338","https://openalex.org/W2113814708","https://openalex.org/W2114850508","https://openalex.org/W2130479394","https://openalex.org/W2136903812","https://openalex.org/W2148143831","https://openalex.org/W2155653061","https://openalex.org/W2157165549","https://openalex.org/W2157255054","https://openalex.org/W2185628700","https://openalex.org/W2320663134","https://openalex.org/W2396907650","https://openalex.org/W2560609797","https://openalex.org/W2753687772","https://openalex.org/W2767891136","https://openalex.org/W2896636431","https://openalex.org/W2900891475","https://openalex.org/W2903705089","https://openalex.org/W2912290085","https://openalex.org/W2923490814","https://openalex.org/W2951569701","https://openalex.org/W2962701877","https://openalex.org/W2963035165","https://openalex.org/W2963121255","https://openalex.org/W2963292194","https://openalex.org/W2968643324","https://openalex.org/W2981359472","https://openalex.org/W2999044305","https://openalex.org/W3005302351","https://openalex.org/W3035002114","https://openalex.org/W3097054638","https://openalex.org/W3177828909","https://openalex.org/W4288346752","https://openalex.org/W4295312788","https://openalex.org/W6743702420","https://openalex.org/W6763352035"],"related_works":["https://openalex.org/W3099772455","https://openalex.org/W3172198228","https://openalex.org/W1986078734","https://openalex.org/W2129301794","https://openalex.org/W1540599686","https://openalex.org/W2016396528","https://openalex.org/W2033001120","https://openalex.org/W2261012589","https://openalex.org/W4377101717","https://openalex.org/W1925092754"],"abstract_inverted_index":{"Transmembrane":[0],"proteins":[1],"(TMPs)":[2],"serve":[3],"as":[4],"drug":[5,30,51,55,138],"targets":[6],"for":[7,50,126],"more":[8],"than":[9],"half":[10],"of":[11,65,73,103,136],"the":[12,17,62,69,86,101,112,134,137],"drugs":[13],"currently":[14],"available":[15],"in":[16],"market.":[18],"However,":[19],"it":[20],"had":[21],"not":[22],"been":[23],"clearly":[24],"explained":[25],"how":[26],"they":[27,106],"realize":[28],"their":[29],"effects":[31],"through":[32],"multiple":[33,74],"complex":[34],"molecules":[35],"bindings":[36,41],"actions.":[37],"Research":[38],"into":[39],"TMPs":[40,66,127],"and":[42,53,105,130],"corresponding":[43],"structural":[44,87,108],"basis":[45,125],"will":[46],"provide":[47],"key":[48],"information":[49],"research":[52,129],"new":[54,123],"development.":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"defined":[61],"binding":[63,70,97,117,128],"domain":[64],"according":[67],"to":[68,84,111],"region":[71],"investigation":[72],"conjugate":[75],"types.":[76],"A":[77],"3D":[78],"deep":[79],"learning":[80],"model":[81],"was":[82],"architected":[83],"discover":[85],"universality":[88],"inside":[89],"those":[90],"domains.":[91],"The":[92],"experimental":[93],"results":[94],"proved":[95],"such":[96],"domains":[98],"existing":[99],"on":[100],"surface":[102,113],"TMPs,":[104],"are":[107],"specific":[109],"distinguishing":[110],"regions":[114],"without":[115],"any":[116],"activities.":[118],"This":[119],"work":[120],"provides":[121],"a":[122],"theoretical":[124],"can":[131],"greatly":[132],"boost":[133],"development":[135],"industry.":[139]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}