{"id":"https://openalex.org/W4206557429","doi":"https://doi.org/10.1109/bibm52615.2021.9669299","title":"Bioinformatics analysis of miRNAs identifies enrichment of axon guidance pathway genes in ovarian cancer stem cells","display_name":"Bioinformatics analysis of miRNAs identifies enrichment of axon guidance pathway genes in ovarian cancer stem cells","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4206557429","doi":"https://doi.org/10.1109/bibm52615.2021.9669299"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669299","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669299","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110968230","display_name":"Shurui Cai","orcid":null},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shurui Cai","raw_affiliation_strings":["Comprehensive Cancer Center, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026503361","display_name":"Renata Fu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134570","display_name":"Scarsdale Public Schools","ror":"https://ror.org/042w3r845","country_code":"US","type":"education","lineage":["https://openalex.org/I4210134570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renata Fu","raw_affiliation_strings":["Scarsdale High School, Scarsdale, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scarsdale High School, Scarsdale, USA","institution_ids":["https://openalex.org/I4210134570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413957","display_name":"Kevin Wang","orcid":"https://orcid.org/0000-0002-9343-6473"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Wang","raw_affiliation_strings":["Columbus Academy, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbus Academy, Columbus, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368012","display_name":"Na Li","orcid":"https://orcid.org/0000-0001-6163-1648"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":["Comprehensive Cancer Center, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353673","display_name":"Hao Chen","orcid":"https://orcid.org/0009-0001-6480-7976"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haowen Chen","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023085664","display_name":"Ellie Xi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129168","display_name":"BASIS International (United States)","ror":"https://ror.org/03q4sef08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129168"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellie Xi","raw_affiliation_strings":["BASIS Independent Silicon Valley, San Jose, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASIS Independent Silicon Valley, San Jose, USA","institution_ids":["https://openalex.org/I4210129168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005732540","display_name":"Daniel Lin","orcid":"https://orcid.org/0000-0002-6203-712X"},"institutions":[{"id":"https://openalex.org/I2799350140","display_name":"Fairview School District","ror":"https://ror.org/01xddfn70","country_code":"US","type":"education","lineage":["https://openalex.org/I2799350140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Lin","raw_affiliation_strings":["Fairview High School, Boulder, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fairview High School, Boulder, USA","institution_ids":["https://openalex.org/I2799350140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063946766","display_name":"Yongsheng Bai","orcid":"https://orcid.org/0000-0002-9944-5426"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongsheng Bai","raw_affiliation_strings":["Next-Gen Intelligent Science Training, Ann Arbor, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Next-Gen Intelligent Science Training, Ann Arbor, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001392257","display_name":"Qi-En Wang","orcid":"https://orcid.org/0000-0001-6220-1404"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi-En Wang","raw_affiliation_strings":["Comprehensive Cancer Center, The Ohio State University, Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, The Ohio State University, Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20833333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"2415","last_page":"2422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7890956401824951},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6699483394622803},{"id":"https://openalex.org/keywords/cancer-stem-cell","display_name":"Cancer stem cell","score":0.6342495679855347},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.629379153251648},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.5852460861206055},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43871498107910156},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4289291501045227},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4249609708786011},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.375744491815567},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3520164489746094},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20525279641151428}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7890956401824951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6699483394622803},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6342495679855347},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.629379153251648},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5852460861206055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43871498107910156},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4289291501045227},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4249609708786011},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.375744491815567},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3520164489746094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20525279641151428}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669299","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669299","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[],"funders":[{"id":"https://openalex.org/F4320316230","display_name":"Pelotonia","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W902285478","https://openalex.org/W1525971429","https://openalex.org/W1563901861","https://openalex.org/W1671531417","https://openalex.org/W1909591771","https://openalex.org/W1966835108","https://openalex.org/W1973721043","https://openalex.org/W1976324983","https://openalex.org/W2028946225","https://openalex.org/W2031806343","https://openalex.org/W2037109948","https://openalex.org/W2047529648","https://openalex.org/W2056302937","https://openalex.org/W2062608680","https://openalex.org/W2064427521","https://openalex.org/W2066113694","https://openalex.org/W2067219166","https://openalex.org/W2067363138","https://openalex.org/W2068416436","https://openalex.org/W2071682538","https://openalex.org/W2074629894","https://openalex.org/W2075995473","https://openalex.org/W2083381199","https://openalex.org/W2084472730","https://openalex.org/W2090982381","https://openalex.org/W2104551938","https://openalex.org/W2105925116","https://openalex.org/W2109678171","https://openalex.org/W2110935705","https://openalex.org/W2112666597","https://openalex.org/W2115954319","https://openalex.org/W2117432441","https://openalex.org/W2121787561","https://openalex.org/W2122535638","https://openalex.org/W2137267184","https://openalex.org/W2140630205","https://openalex.org/W2145506897","https://openalex.org/W2158217645","https://openalex.org/W2161884651","https://openalex.org/W2444066332","https://openalex.org/W2514594194","https://openalex.org/W2594964753","https://openalex.org/W2610504281","https://openalex.org/W2615902603","https://openalex.org/W2736520162","https://openalex.org/W2782790872","https://openalex.org/W2801001438","https://openalex.org/W2916929018","https://openalex.org/W2922713651","https://openalex.org/W2951506747","https://openalex.org/W2964508022","https://openalex.org/W2970358232","https://openalex.org/W3119005666","https://openalex.org/W4210987384","https://openalex.org/W4243541841","https://openalex.org/W4366133316","https://openalex.org/W6640755060"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2050308539","https://openalex.org/W3151405604","https://openalex.org/W4241694095","https://openalex.org/W2330252996","https://openalex.org/W2339474595","https://openalex.org/W2057742104","https://openalex.org/W4283692078"],"abstract_inverted_index":{"Ovarian":[0],"cancer":[1,5,16,31,41,80,133,185],"ranks":[2],"fifth":[3],"in":[4,53,74,82],"deaths":[6,12],"among":[7],"women,":[8],"accounting":[9],"for":[10,40],"more":[11],"than":[13],"any":[14],"other":[15],"of":[17,30,50,107,119,126,147,169],"the":[18,38,47,104,143,148,173],"female":[19],"reproductive":[20],"system.":[21],"Cancer":[22],"stem":[23],"cells":[24,32,81],"(CSCs)":[25],"are":[26,34],"a":[27,97],"small":[28],"population":[29],"that":[33,163],"believed":[35],"to":[36],"be":[37],"reason":[39],"initiation":[42],"and":[43,55,84,122],"tumor":[44],"relapse.":[45],"Recently,":[46],"important":[48,145],"role":[49,146],"MicroRNAs":[51],"(miRNAs)":[52],"maintaining":[54],"regulating":[56,172],"CSCs":[57,76,170],"through":[58],"targeting":[59],"multiple":[60,155],"oncogenic":[61],"signaling":[62],"pathways":[63],"has":[64],"been":[65],"reported.":[66],"Previously,":[67],"we":[68,102,114,140],"have":[69],"found":[70,115],"differentially":[71,109],"expressed":[72,110],"miRNAs":[73,121],"ovarian":[75],"compared":[77],"with":[78,96],"bulk":[79],"SKOV3":[83],"Kuramochi":[85],"cell":[86,134],"lines.":[87],"Here":[88],"using":[89,154],"online":[90],"miRNA":[91,165],"target":[92],"prediction":[93],"tools":[94],"combined":[95],"web":[98],"interface":[99],"tool":[100],"MMiRNA-Tar,":[101],"identified":[103,162],"downstream":[105],"targets":[106,118,125],"these":[108],"miRNAs.":[111],"After":[112],"filtering,":[113],"271":[116],"novel":[117,124,184],"downregulated":[120],"442":[123],"upregulated":[127],"miRNAs,":[128],"which":[129,178],"may":[130],"potentially":[131,144],"control":[132],"stemness.":[135],"Among":[136],"this":[137],"gene":[138],"list,":[139],"further":[141],"validated":[142],"axon":[149,174],"guidance":[150,175],"pathway":[151,176],"genes":[152],"by":[153,171],"bioinformatic":[156],"analyses.":[157],"In":[158],"summary,":[159],"our":[160],"study":[161],"dysregulated":[164],"can":[166],"facilitate":[167],"maintenance":[168],"genes,":[177],"will":[179],"ultimately":[180],"help":[181],"us":[182],"find":[183],"therapeutic":[186],"targets.":[187]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}