{"id":"https://openalex.org/W4205147970","doi":"https://doi.org/10.1109/bibm52615.2021.9669290","title":"Effects of Shugan Quzhi Capsule in treating different metabolic diseases based on network pharmacology and molecular docking","display_name":"Effects of Shugan Quzhi Capsule in treating different metabolic diseases based on network pharmacology and molecular docking","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4205147970","doi":"https://doi.org/10.1109/bibm52615.2021.9669290"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669290","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669290","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056441836","display_name":"Weijie Lin","orcid":"https://orcid.org/0000-0002-1894-4267"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105182","display_name":"Zhuhai People's Hospital","ror":"https://ror.org/01k1x3b35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijie Lin","raw_affiliation_strings":["Department of Pharmacy, Zhuhai People\u2019s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","Department of Pharmacy, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Zhuhai People\u2019s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105182"]},{"raw_affiliation_string":"Department of Pharmacy, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101651858","display_name":"Zhengrong Liu","orcid":"https://orcid.org/0000-0001-9709-0425"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengrong Liu","raw_affiliation_strings":["College of pharmacy, Shanghai university of Medicine and Health Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of pharmacy, Shanghai university of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435324","display_name":"Ling Li","orcid":"https://orcid.org/0000-0002-0087-3034"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Li","raw_affiliation_strings":["Department of Pharmacy, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210113039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047917374","display_name":"Zhiling Zhou","orcid":"https://orcid.org/0000-0001-8510-7883"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105182","display_name":"Zhuhai People's Hospital","ror":"https://ror.org/01k1x3b35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiling Zhou","raw_affiliation_strings":["Department of Pharmacy, Zhuhai People\u2019s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","Department of Pharmacy, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Zhuhai People\u2019s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105182"]},{"raw_affiliation_string":"Department of Pharmacy, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101936822","display_name":"Shiyu Ma","orcid":"https://orcid.org/0000-0003-4222-761X"},"institutions":[{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Ma","raw_affiliation_strings":["Department of Pharmacy, School of Medicine, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Medicine, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China","institution_ids":["https://openalex.org/I2801556517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063548954","display_name":"Fazhong He","orcid":"https://orcid.org/0000-0001-5750-0135"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105182","display_name":"Zhuhai People's Hospital","ror":"https://ror.org/01k1x3b35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fazhong He","raw_affiliation_strings":["Department of Pharmacy, Zhuhai People\u2019s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","Department of Pharmacy, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Zhuhai People\u2019s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105182"]},{"raw_affiliation_string":"Department of Pharmacy, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105182"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"3832","last_page":"3839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9819999933242798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6379919052124023},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5202104449272156},{"id":"https://openalex.org/keywords/capsule","display_name":"Capsule","score":0.5127633213996887},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4031468629837036},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38683536648750305},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.341232568025589},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17156970500946045}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6379919052124023},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5202104449272156},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.5127633213996887},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4031468629837036},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38683536648750305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.341232568025589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17156970500946045},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669290","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669290","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1963623884","https://openalex.org/W1971634248","https://openalex.org/W1982830461","https://openalex.org/W1987268531","https://openalex.org/W1989838345","https://openalex.org/W2008175363","https://openalex.org/W2009377079","https://openalex.org/W2025011193","https://openalex.org/W2033378879","https://openalex.org/W2067647130","https://openalex.org/W2078831149","https://openalex.org/W2095866442","https://openalex.org/W2103478816","https://openalex.org/W2106369210","https://openalex.org/W2112317454","https://openalex.org/W2117124225","https://openalex.org/W2141662760","https://openalex.org/W2149287982","https://openalex.org/W2338864525","https://openalex.org/W2345415171","https://openalex.org/W2402297387","https://openalex.org/W2514509694","https://openalex.org/W2534390616","https://openalex.org/W2771538940","https://openalex.org/W2791641807","https://openalex.org/W2807500148","https://openalex.org/W2885265365","https://openalex.org/W2896718719","https://openalex.org/W2901491111","https://openalex.org/W2902419609","https://openalex.org/W2913237386","https://openalex.org/W2922027633","https://openalex.org/W2969278114","https://openalex.org/W3003827798","https://openalex.org/W3092129163","https://openalex.org/W3153427568","https://openalex.org/W3162263365","https://openalex.org/W3189144310"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"Purpose:":[0],"We":[1],"explored":[2],"the":[3,32,91,133,143,155,174,184,190],"mechanism":[4],"effects":[5],"of":[6,57,135,137,145],"\u201cThe":[7,146],"Same":[8,147],"Treatment":[9,148],"for":[10,105,149,179],"Different":[11,151],"metabolic":[12,124,150],"Diseases\u201d":[13,152],"concept":[14],"in":[15,61,74,109,198],"traditional":[16],"Chinese":[17],"medicine":[18],"(TCM).Methods:":[19],"Network":[20],"pharmacology,":[21],"molecular":[22],"docking":[23],"technology":[24],"and":[25,34,50,86,112,122,157,165,167,177,186,196],"KATZ":[26],"score":[27],"were":[28,63,72,98],"employed":[29],"to":[30,46,65,79],"predict":[31],"targets":[33,176],"signaling":[35,107],"pathways":[36,97,172,178],"affected":[37],"by":[38,193],"Shugan":[39],"Quzhi":[40],"Capsules":[41],"(SGQZ),":[42],"which":[43,194],"are":[44,173,189],"used":[45],"treat":[47],"obesity,":[48],"hyperlipidemia,":[49],"non-alcoholic":[51],"fatty":[52],"liver":[53,187],"disease.Results:":[54],"A":[55],"total":[56],"492":[58],"active":[59],"ingredients":[60],"SGQZ":[62,121,138,199],"found":[64],"act":[66],"on":[67,139],"666":[68],"potential":[69],"targets.":[70],"They":[71],"involved":[73],"GO":[75],"biological":[76],"processes":[77],"related":[78],"lipid":[80],"metabolism,":[81],"oxidative":[82],"stress,":[83],"anti-inflammatory":[84],"effects,":[85],"calcium":[87],"ion":[88],"channel":[89],"effects;":[90],"three":[92,140],"most":[93],"significantly":[94],"enriched":[95],"KEGG":[96],"endocrine":[99],"resistance,":[100],"advanced":[101],"glycation":[102],"end-product":[103],"(AGE)/receptor":[104],"AGEs":[106],"pathway":[108,158],"diabetic":[110],"complications,":[111],"peroxisome":[113],"proliferator-activated":[114],"receptor":[115],"(PPAR)":[116],"signaling.":[117],"The":[118],"correlation":[119],"between":[120],"each":[123],"disease":[125],"was":[126],"ranked":[127],"as":[128],"NAFLD>hyperlipidemia>obesity.Conclusions:":[129],"Our":[130],"results":[131],"clarify":[132],"mechanisms":[134],"action":[136],"conditions,":[141],"demonstrating":[142],"utility":[144],"from":[153],"both":[154],"target":[156],"perspectives.":[159],"Among":[160],"them,":[161],"leptin,":[162],"apolipoprotein":[163],"B,":[164],"PPARG":[166],"PPAR-/AMP-activated":[168],"protein":[169],"kinase-related":[170],"signal":[171],"key":[175,191],"SGQZ.":[180],"In":[181],"TCM":[182],"terminology,":[183],"spleen":[185],"meridians":[188],"routes":[192],"quercetin":[195],"apigenin":[197],"exert":[200],"their":[201],"effects.":[202]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}