{"id":"https://openalex.org/W3128542833","doi":"https://doi.org/10.1109/bibm49941.2020.9313529","title":"Genome-wide association study identified genetic variants associated with severity of COPD in Korean participants","display_name":"Genome-wide association study identified genetic variants associated with severity of COPD in Korean participants","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https://openalex.org/W3128542833","doi":"https://doi.org/10.1109/bibm49941.2020.9313529","mag":"3128542833"},"language":"en","primary_location":{"id":"doi:10.1109/bibm49941.2020.9313529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313529","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068876656","display_name":"Geumkyung Nah","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Geumkyung Nah","raw_affiliation_strings":["Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462894","display_name":"Jiwon Kim","orcid":"https://orcid.org/0000-0002-8420-8604"},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiwon Kim","raw_affiliation_strings":["Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103867536","display_name":"Eun-A Choi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-A Choi","raw_affiliation_strings":["Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038356858","display_name":"Jeom\u2010Kyu Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeomkyu Lee","raw_affiliation_strings":["Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Woojin Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109191","display_name":"Kangwon National University Hospital","ror":"https://ror.org/01rf1rj96","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210109191"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woojin Kim","raw_affiliation_strings":["Depart of Internal Medicine and Environmental Health Center, Kangwon National University Hospital School of Medicine Kangwon National University, Chuncheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depart of Internal Medicine and Environmental Health Center, Kangwon National University Hospital School of Medicine Kangwon National University, Chuncheon, Korea","institution_ids":["https://openalex.org/I4210109191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033517259","display_name":"Kwang Ha Yoo","orcid":"https://orcid.org/0000-0001-9969-2657"},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwangha Yoo","raw_affiliation_strings":["Division of Pulmonary Allergy and Critical Care Medicine, Konkuk University School of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Konkuk University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054310571","display_name":"Dankyu Yoon","orcid":"https://orcid.org/0000-0003-3409-2399"},"institutions":[{"id":"https://openalex.org/I4210148299","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066","country_code":"KR","type":"government","lineage":["https://openalex.org/I4210148299"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dankyu Yoon","raw_affiliation_strings":["Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Chronic Respiratory Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Korea","institution_ids":["https://openalex.org/I4210148299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2984","last_page":"2986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/3604","display_name":"Emergency Medical Services"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8776253461837769},{"id":"https://openalex.org/keywords/copd","display_name":"COPD","score":0.8129382133483887},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5739325881004333},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.52938312292099},{"id":"https://openalex.org/keywords/pulmonary-disease","display_name":"Pulmonary disease","score":0.5247970819473267},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5147316455841064},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.5036527514457703},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.46104687452316284},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4354860186576843},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3811642527580261},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37900906801223755},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3660677671432495},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.3011243939399719},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24118316173553467},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23206040263175964},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.22947347164154053}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8776253461837769},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8129382133483887},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5739325881004333},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.52938312292099},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.5247970819473267},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5147316455841064},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5036527514457703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46104687452316284},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4354860186576843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3811642527580261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37900906801223755},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3660677671432495},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3011243939399719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24118316173553467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23206040263175964},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.22947347164154053}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm49941.2020.9313529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313529","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5799999833106995}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2127951128","https://openalex.org/W2164563303","https://openalex.org/W2510973425","https://openalex.org/W2529241974","https://openalex.org/W2736569063","https://openalex.org/W2777667999","https://openalex.org/W2901303766","https://openalex.org/W3008726958"],"related_works":["https://openalex.org/W2326585857","https://openalex.org/W142525846","https://openalex.org/W2312602415","https://openalex.org/W2312864656","https://openalex.org/W2472126364","https://openalex.org/W2320098543","https://openalex.org/W2585009645","https://openalex.org/W2333131755","https://openalex.org/W4401482945","https://openalex.org/W2372297656"],"abstract_inverted_index":{"Chronic":[0],"Obstructive":[1],"Pulmonary":[2],"Diseases":[3],"(COPD)":[4],"is":[5],"a":[6,21],"complex":[7],"disease":[8],"with":[9],"considerable":[10],"variability":[11],"affecting":[12],"about":[13],"65":[14],"million":[15],"individuals":[16],"[1].":[17],"We":[18],"therefore":[19],"performed":[20],"genome-wide":[22],"association":[23],"study":[24],"(GWAS)":[25],"of":[26,63],"COPD":[27],"severity.":[28],"Thirty-four":[29],"genetic":[30,52],"variants":[31],"were":[32,42],"identified":[33],"(P":[34],"<;":[35],"1.0\u00d710":[36],"<sup":[37],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[38],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">-5</sup>":[39],"),":[40],"and":[41,46],"located":[43],"in":[44],"intron":[45],"upstream/downstream":[47],"regions.":[48],"In":[49],"conclusion,":[50],"these":[51],"markers":[53],"could":[54],"provide":[55],"insight":[56],"into":[57],"the":[58,60],"understanding":[59],"pathological":[61],"process":[62],"COPD.":[64]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}