{"id":"https://openalex.org/W3128111203","doi":"https://doi.org/10.1109/bibm49941.2020.9313498","title":"Artificial Neural Network System for Cell Classification using Single Cell RNA Expression","display_name":"Artificial Neural Network System for Cell Classification using Single Cell RNA Expression","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https://openalex.org/W3128111203","doi":"https://doi.org/10.1109/bibm49941.2020.9313498","mag":"3128111203"},"language":"en","primary_location":{"id":"doi:10.1109/bibm49941.2020.9313498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313498","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089237967","display_name":"Xin Lin","orcid":"https://orcid.org/0000-0002-7468-0366"},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Lin","raw_affiliation_strings":["School of Computer Science, University of Nottingham, Ningbo, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Nottingham, Ningbo, China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049307678","display_name":"Jiahui Zhong","orcid":"https://orcid.org/0000-0001-5878-976X"},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahui Zhong","raw_affiliation_strings":["School of Computer Science, University of Nottingham, Ningbo, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Nottingham, Ningbo, China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063237235","display_name":"Minjie Lyu","orcid":"https://orcid.org/0000-0002-0084-847X"},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minjie Lyu","raw_affiliation_strings":["School of Computer Science, University of Nottingham, Ningbo, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Nottingham, Ningbo, China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010402660","display_name":"Sen Lin","orcid":"https://orcid.org/0000-0003-2051-3500"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sen Lin","raw_affiliation_strings":["School of Computer Science, University of Nottingham, Nottingham, UK"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000801624","display_name":"Derin B. Keskin","orcid":"https://orcid.org/0000-0002-8496-6181"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derin B. Keskin","raw_affiliation_strings":["Harvard Medical School, Dana-Farber Cancer Institute, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Dana-Farber Cancer Institute, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049107377","display_name":"Guanglan Zhang","orcid":"https://orcid.org/0000-0001-6010-490X"},"institutions":[{"id":"https://openalex.org/I92609107","display_name":"Metropolitan College of New York","ror":"https://ror.org/012saek46","country_code":"US","type":"education","lineage":["https://openalex.org/I92609107"]},{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanglan Zhang","raw_affiliation_strings":["HiLab, Metropolitan College, Boston University, Boston, USA"],"affiliations":[{"raw_affiliation_string":"HiLab, Metropolitan College, Boston University, Boston, USA","institution_ids":["https://openalex.org/I92609107","https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089063979","display_name":"Vladimir Brusi\u0107","orcid":"https://orcid.org/0000-0003-0523-5266"},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Vladimir Brusic","raw_affiliation_strings":["School of Computer Science, University of Nottingham, Ningbo, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Nottingham, Ningbo, China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090707605","display_name":"Lou Chitkushev","orcid":"https://orcid.org/0000-0002-9365-8818"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I92609107","display_name":"Metropolitan College of New York","ror":"https://ror.org/012saek46","country_code":"US","type":"education","lineage":["https://openalex.org/I92609107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lou T. Chitkushev","raw_affiliation_strings":["HiLab, Metropolitan College, Boston University, Boston, USA"],"affiliations":[{"raw_affiliation_string":"HiLab, Metropolitan College, Boston University, Boston, USA","institution_ids":["https://openalex.org/I92609107","https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5089237967"],"corresponding_institution_ids":["https://openalex.org/I13591777"],"apc_list":null,"apc_paid":null,"fwci":0.6628,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68152295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1253","last_page":"1257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.7244547009468079},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6709414124488831},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6645164489746094},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5547745823860168},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5098416209220886},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.43277284502983093},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.407867431640625},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39329808950424194}],"concepts":[{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.7244547009468079},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6709414124488831},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6645164489746094},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5547745823860168},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5098416209220886},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.43277284502983093},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.407867431640625},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39329808950424194},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm49941.2020.9313498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313498","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:eprints.nottingham.ac.uk:64682","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402013","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Conference or Workshop Item"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1580018887","https://openalex.org/W1873332500","https://openalex.org/W2049248002","https://openalex.org/W2092138236","https://openalex.org/W2295526809","https://openalex.org/W2341128841","https://openalex.org/W2603911319","https://openalex.org/W2734950973","https://openalex.org/W2788071652","https://openalex.org/W2926010705","https://openalex.org/W2951506174","https://openalex.org/W3003807737","https://openalex.org/W3005127469","https://openalex.org/W3005291517","https://openalex.org/W3015184839","https://openalex.org/W3032541765","https://openalex.org/W3042462196","https://openalex.org/W3127460854","https://openalex.org/W4385319365"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W2391251536","https://openalex.org/W2027108423","https://openalex.org/W1855666948","https://openalex.org/W2758561209","https://openalex.org/W1548095260","https://openalex.org/W2594414941","https://openalex.org/W2781711915","https://openalex.org/W2112817590","https://openalex.org/W1555291398"],"abstract_inverted_index":{"We":[0,39,82],"implemented":[1],"an":[2,65],"automated":[3],"system":[4,14,42,96],"for":[5],"single-cell":[6,16],"classification":[7,79,109],"using":[8,64],"artificial":[9],"neural":[10],"networks":[11],"(ANN).":[12],"Our":[13],"takes":[15],"gene":[17],"expression":[18],"sparse":[19],"matrices":[20],"and":[21,28,59,84,121],"trains":[22],"ANN":[23],"to":[24,118],"classify":[25],"cell":[26,35],"types":[27,120],"subtypes.":[29],"The":[30,73,94,100],"assemblies":[31],"of":[32,69,76,88,102],"ANNs":[33,50,90],"predict":[34],"classes":[36],"by":[37],"voting.":[38],"tested":[40,60,85],"the":[41,61,77,112,124],"in":[43,91,123],"a":[44,52,86],"case":[45],"study":[46],"where":[47],"we":[48],"trained":[49,83],"with":[51],"dataset":[53],"containing":[54],"approximately":[55],"120,000":[56],"single":[57,71],"cells":[58],"resulting":[62],"model":[63],"independent":[66],"data":[67],"set":[68],"13,000":[70],"cells.":[72],"overall":[74],"accuracy":[75],"5-class":[78],"was":[80],"95%.":[81],"total":[87],"100":[89],"10":[92],"cycles.":[93],"prediction":[95],"demonstrated":[97],"excellent":[98],"reproducibility.":[99],"analysis":[101],"misclassifications":[103],"indicated":[104],"that":[105],"2%":[106],"were":[107,115],"likely":[108,116],"errors,":[110],"while":[111],"remaining":[113],"3%":[114],"due":[117],"mislabeled":[119],"subtypes":[122],"test":[125],"set.":[126]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}