{"id":"https://openalex.org/W3128552172","doi":"https://doi.org/10.1109/bibm49941.2020.9313457","title":"A T1D-associated lncRNA modulates the type I interferon signaling and the antiviral response in pancreatic beta cells","display_name":"A T1D-associated lncRNA modulates the type I interferon signaling and the antiviral response in pancreatic beta cells","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https://openalex.org/W3128552172","doi":"https://doi.org/10.1109/bibm49941.2020.9313457","mag":"3128552172"},"language":"en","primary_location":{"id":"doi:10.1109/bibm49941.2020.9313457","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313457","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034652559","display_name":"Itziar Gonz\u00e1lez\u2010Moro","orcid":"https://orcid.org/0000-0002-6504-4931"},"institutions":[{"id":"https://openalex.org/I4210089430","display_name":"BioCruces Health research Institute","ror":"https://ror.org/0061s4v88","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210089430"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Itziar Gonzalez-Moro","raw_affiliation_strings":["University of the Basque Country,Dept. Biochemistry and Molecular Biology,Leioa,Spain","Biocruces Health Research Institute, Barakaldo, Spain"],"affiliations":[{"raw_affiliation_string":"University of the Basque Country,Dept. Biochemistry and Molecular Biology,Leioa,Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Biocruces Health Research Institute, Barakaldo, Spain","institution_ids":["https://openalex.org/I4210089430"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048492409","display_name":"Izortze Sant\u00edn","orcid":"https://orcid.org/0000-0003-1651-6776"},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210089430","display_name":"BioCruces Health research Institute","ror":"https://ror.org/0061s4v88","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210089430"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Izortze Santin","raw_affiliation_strings":["University of the Basque Country,Dept. Biochemistry and Molecular Biology,Leioa,Spain","Biocruces Health Research Institute, Barakaldo, Spain","CIBERDEM, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"University of the Basque Country,Dept. Biochemistry and Molecular Biology,Leioa,Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Biocruces Health Research Institute, Barakaldo, Spain","institution_ids":["https://openalex.org/I4210089430"]},{"raw_affiliation_string":"CIBERDEM, Madrid, Spain","institution_ids":["https://openalex.org/I4210092133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034652559"],"corresponding_institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210089430"],"apc_list":null,"apc_paid":null,"fwci":0.0799,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.40080561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"2914","last_page":"2917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7114771008491516},{"id":"https://openalex.org/keywords/interferon","display_name":"Interferon","score":0.5803757309913635},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4757266342639923},{"id":"https://openalex.org/keywords/transfection","display_name":"Transfection","score":0.4524662494659424},{"id":"https://openalex.org/keywords/beta-cell","display_name":"Beta cell","score":0.442581444978714},{"id":"https://openalex.org/keywords/irf7","display_name":"IRF7","score":0.44056329131126404},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4341930150985718},{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.42905741930007935},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3786284923553467},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3492862582206726},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2935435175895691},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.19911935925483704},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.09635558724403381}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7114771008491516},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5803757309913635},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4757266342639923},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4524662494659424},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.442581444978714},{"id":"https://openalex.org/C2776966659","wikidata":"https://www.wikidata.org/wiki/Q18028003","display_name":"IRF7","level":4,"score":0.44056329131126404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4341930150985718},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42905741930007935},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3786284923553467},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3492862582206726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2935435175895691},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.19911935925483704},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.09635558724403381},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm49941.2020.9313457","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9313457","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2043204562","https://openalex.org/W2055492712","https://openalex.org/W2077955816","https://openalex.org/W2123087478","https://openalex.org/W2902429984","https://openalex.org/W2942809049","https://openalex.org/W2971451528","https://openalex.org/W3015628544"],"related_works":["https://openalex.org/W2946961190","https://openalex.org/W3123689060","https://openalex.org/W2104489108","https://openalex.org/W2124367124","https://openalex.org/W3118354813","https://openalex.org/W2892942268","https://openalex.org/W2068284531","https://openalex.org/W2160045547","https://openalex.org/W2098128683","https://openalex.org/W2674947112"],"abstract_inverted_index":{"Type":[0],"1":[1],"diabetes":[2],"(T1D)":[3],"is":[4,82,101,116,128,134,189,287],"a":[5,83,86,102,203,220,267,290,302],"complex":[6],"autoimmune":[7,23],"disease":[8],"in":[9,97,130,140,185,191,197,206,211,237,270,277,293,299,340,347],"which":[10,69,115,326],"genetic":[11],"factors":[12],"interact":[13],"with":[14,118,213,301],"environmental":[15],"changes":[16],"(e.g.":[17],"viral":[18,180,221,291,303],"infections)":[19],"to":[20,51,74,78,93,218,265,320,336],"trigger":[21],"an":[22,111,157],"assault":[24],"against":[25],"insulin":[26],"producing":[27],"pancreatic":[28,152,186,278,294],"\u03b2-cells.":[29,187,279,295],"The":[30],"majority":[31],"of":[32,42,59,146,167,194,226,230,274,297,308,332],"T1D-associated":[33,87,119,126],"single":[34],"nucleotide":[35],"polymorphisms":[36],"(SNPs)":[37],"lay":[38],"into":[39,122],"non-coding":[40,61,71],"regions":[41],"the":[43,53,65,106,125,144,147,151,192,224,231,257,271,306,313,322,330],"human":[44],"genome":[45],"and":[46,57,155,161,179,199,242,254,335,344],"many":[47],"have":[48,170],"been":[49,91,263],"predicted":[50],"affect":[52],"expression,":[54],"secondary":[55],"structure":[56],"function":[58],"long":[60],"RNAs":[62],"(lncRNAs).":[63],"However,":[64],"molecular":[66,323],"mechanisms":[67,324],"by":[68,325],"these":[70],"molecules":[72],"contribute":[73],"T1D":[75,141,275,345],"pathogenesis":[76,276],"remain":[77],"be":[79,138],"clarified.":[80],"Lnc10":[81,136,183,188,209,286,298],"lncRNA":[84,328],"harboring":[85],"SNP":[88,127],"that":[89,104,124,135,172,285],"has":[90,262],"described":[92],"control":[94],"Ebi2":[95,100],"expression":[96,184,225,307,331],"immune":[98],"cells.":[99],"trans-eQTL":[103],"regulates":[105,329],"IRF7-driven":[107],"inflammatory":[108],"network":[109,114,149],"(iDIN),":[110],"antiviral":[112,159,228,243,310],"gene":[113],"enriched":[117],"genes.":[120],"Taking":[121],"account":[123],"located":[129,190],"Lnc10,":[131],"our":[132,168,282],"hypothesis":[133],"might":[137],"dysregulated":[139],"patients,":[142],"influencing":[143],"regulation":[145],"iDIN":[148,232,314,333],"at":[150],"\u03b2-cell":[153,163,342],"level":[154],"provoking":[156],"exacerbated":[158],"response,":[160],"eventually,":[162],"destruction.":[164],"Preliminary":[165],"results":[166,283],"group":[169],"demonstrated":[171],"diabetogenic":[173],"stimuli,":[174],"such":[175],"as":[176],"pro-inflammatory":[177],"cytokines":[178],"infections,":[181],"upregulate":[182],"nuclei":[193],"\u03b2-cells,":[195],"both":[196],"basal":[198],"stimulated":[200],"conditions,":[201],"suggesting":[202],"potential":[204],"role":[205,269],"transcriptional":[207],"regulation.":[208],"overexpression":[210],"combination":[212,300],"polyinosinic:polycytidylic":[214],"acid":[215],"(PIC)":[216],"transfection":[217],"mimic":[219],"infection,":[222],"increased":[223],"several":[227,309],"genes":[229,236,311,334],"pathway,":[233],"including":[234],"key":[235],"type":[238,258],"I":[239,259],"IFN":[240,260],"signaling":[241,261],"response":[244],"(STAT1,":[245],"CXCL1,":[246],"GBP1,":[247],"SP110,":[248],"TAP2,":[249],"IFITM1,":[250],"DYNLT1,":[251],"MAP3K7,":[252],"CCL2":[253],"ERAP1).":[255],"Interestingly,":[256],"shown":[264],"play":[266],"crucial":[268],"initial":[272],"stages":[273],"In":[280],"conclusion,":[281],"show":[284],"upregulated":[288],"after":[289],"infection":[292,304],"Upregulation":[296],"exacerbates":[305],"from":[312],"pathway.":[315],"Further":[316],"studies":[317],"are":[318],"required":[319],"elucidate":[321],"this":[327],"determine":[337],"its":[338],"impact":[339],"virus-induced":[341],"dysfunction":[343],"development":[346],"genetically":[348],"susceptible":[349],"individuals.":[350]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
