{"id":"https://openalex.org/W3126239870","doi":"https://doi.org/10.1109/bibm49941.2020.9312986","title":"Evaluation of the predictive capability of PETAL tool: a retrospective study on potential tyrosine kinases drug resistance targets","display_name":"Evaluation of the predictive capability of PETAL tool: a retrospective study on potential tyrosine kinases drug resistance targets","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https://openalex.org/W3126239870","doi":"https://doi.org/10.1109/bibm49941.2020.9312986","mag":"3126239870"},"language":"en","primary_location":{"id":"doi:10.1109/bibm49941.2020.9312986","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9312986","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078384674","display_name":"Giuseppe Sgroi","orcid":"https://orcid.org/0000-0001-5062-4696"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Sgroi","raw_affiliation_strings":["University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003874484","display_name":"Marzio Pennisi","orcid":"https://orcid.org/0000-0003-0231-7653"},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzio Pennisi","raw_affiliation_strings":["Computer Science Institute, DiSIT University of Eastern Piedmont, Alessandria, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science Institute, DiSIT University of Eastern Piedmont, Alessandria, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004880055","display_name":"Giulia Russo","orcid":"https://orcid.org/0000-0001-6616-7856"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Russo","raw_affiliation_strings":["University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025331591","display_name":"Giuseppe Alessandro Parasiliti Palumbo","orcid":"https://orcid.org/0000-0003-4646-9851"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Alessandro Parasiliti Palumbo","raw_affiliation_strings":["University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2901,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.80257511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1275","last_page":"1280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.5698837041854858},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5668216347694397},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.47385767102241516},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4269808828830719},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4010828733444214},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.35023343563079834},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33658847212791443},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32985979318618774},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.170171320438385},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1373138427734375},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.13403582572937012}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.5698837041854858},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5668216347694397},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.47385767102241516},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4269808828830719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4010828733444214},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35023343563079834},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33658847212791443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32985979318618774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.170171320438385},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1373138427734375},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.13403582572937012}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm49941.2020.9312986","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9312986","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W950232622","https://openalex.org/W1771999207","https://openalex.org/W1965031944","https://openalex.org/W1975233115","https://openalex.org/W2004480757","https://openalex.org/W2006778392","https://openalex.org/W2010862107","https://openalex.org/W2012161830","https://openalex.org/W2027136253","https://openalex.org/W2042359627","https://openalex.org/W2046623154","https://openalex.org/W2061961527","https://openalex.org/W2066424162","https://openalex.org/W2090448257","https://openalex.org/W2102439908","https://openalex.org/W2104297794","https://openalex.org/W2125481927","https://openalex.org/W2135415614","https://openalex.org/W2142237411","https://openalex.org/W2159482845","https://openalex.org/W2161682775","https://openalex.org/W2166863889","https://openalex.org/W2171348543","https://openalex.org/W2181616869","https://openalex.org/W2224812643","https://openalex.org/W2365316759","https://openalex.org/W2614327605","https://openalex.org/W2765481834","https://openalex.org/W2776622814","https://openalex.org/W2792821195","https://openalex.org/W2802787991","https://openalex.org/W2903072518","https://openalex.org/W2910479944","https://openalex.org/W2956229174","https://openalex.org/W2989619704","https://openalex.org/W3011469361","https://openalex.org/W3111940288"],"related_works":["https://openalex.org/W1964572291","https://openalex.org/W4387948744","https://openalex.org/W1987520879","https://openalex.org/W184793361","https://openalex.org/W2352732738","https://openalex.org/W2123060905","https://openalex.org/W2559588208","https://openalex.org/W1984964356","https://openalex.org/W3120676751","https://openalex.org/W1923384484"],"abstract_inverted_index":{"An":[0],"ever-increasing":[1],"number":[2],"of":[3,9,47,108,151,196,204],"tools":[4],"and":[5,11,19,29,54,71,93,95,100,118,139,148,154,200,207],"databases":[6],"offers":[7],"pieces":[8],"evidence":[10],"knowledge":[12],"about":[13,104],"gene":[14],"function":[15],"annotations,":[16],"protein":[17],"interactions,":[18],"experimentally":[20],"validated":[21],"biological":[22,198],"pathways.":[23],"These":[24],"resources":[25],"represent":[26,184],"an":[27],"excellent":[28],"essential":[30],"instrument":[31],"to":[32,43,111,123,127,166,192],"facilitate":[33],"pathway":[34],"analysis.":[35],"Among":[36],"them,":[37],"particular":[38],"attention":[39],"should":[40],"be":[41,190],"given":[42],"the":[44,73,157,168,173,194,202],"one":[45],"capable":[46],"finding":[48],"alternative":[49],"pathways":[50,199],"or":[51],"cross-talks":[52],"events":[53],"potential":[55,105,132,205],"drug":[56,109],"target":[57,133],"candidates.":[58],"Here,":[59],"we":[60,120,160],"evaluated":[61],"PETAL":[62,122,163,182],"predictive":[63],"capability,":[64],"a":[65,77,185],"Python":[66],"tool":[67,187],"that":[68,162,181,188],"automatically":[69],"explores":[70],"scans":[72],"relevant":[74],"nodes":[75,150],"within":[76],"KEGG":[78],"pathway.":[79],"Starting":[80],"from":[81],"three":[82],"specific":[83],"cancer":[84,211],"scenarios":[85],"(chronic":[86],"myelogenous":[87],"leukemia,":[88],"non-small":[89],"cell":[90,98],"lung":[91],"cancer,":[92],"head":[94],"neck":[96],"squamous":[97],"carcinoma)":[99],"related":[101],"literature":[102],"results":[103],"driver":[106],"genes":[107,134],"resistance":[110],"EGFR":[112,140,158],"tyrosine":[113],"kinases":[114],"inhibitors":[115,141],"(SNCA,":[116],"BCL-6":[117,153],"YAP-1),":[119],"used":[121,191],"test":[124],"its":[125],"capability":[126],"identify":[128],"in":[129,136,172,210,213],"parallel":[130],"these":[131],"involved":[135],"tumor":[137],"progression":[138],"resistance.":[142],"By":[143],"searching":[144],"in-depth":[145],"for":[146],"ancestor":[147],"descendent":[149],"SNCA,":[152],"YAP-1,":[155],"across":[156],"pathway,":[159],"found":[161],"was":[164],"able":[165],"detect":[167],"same":[169],"targets":[170],"investigated":[171],"recent":[174],"literature.":[175],"Finally,":[176],"this":[177],"retrospective":[178],"work":[179],"emphasizes":[180],"could":[183],"powerful":[186],"can":[189],"improve":[193],"understanding":[195],"complex":[197],"speed-up":[201],"identification":[203],"biomarkers":[206],"therapeutical":[208],"candidates":[209],"potentially":[212],"any":[214],"other":[215],"disease.":[216]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
