{"id":"https://openalex.org/W3004477182","doi":"https://doi.org/10.1109/bibm47256.2019.8983204","title":"A Robust Approach to Locate HER2 and CEN17 Signals in Varied FISH Images","display_name":"A Robust Approach to Locate HER2 and CEN17 Signals in Varied FISH Images","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W3004477182","doi":"https://doi.org/10.1109/bibm47256.2019.8983204","mag":"3004477182"},"language":"en","primary_location":{"id":"doi:10.1109/bibm47256.2019.8983204","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm47256.2019.8983204","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078850933","display_name":"Jiasheng Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiasheng Liu","raw_affiliation_strings":["School of Computer Science, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446328","display_name":"Juan Liu","orcid":"https://orcid.org/0000-0003-1069-2875"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["School of Computer Science, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752256","display_name":"Yuqi Chen","orcid":"https://orcid.org/0000-0001-9769-1167"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Chen","raw_affiliation_strings":["School of Computer Science, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012232907","display_name":"Chunbing Hua","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunbing Hua","raw_affiliation_strings":["School of Computer Science, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615187","display_name":"Zhuoyu Li","orcid":"https://orcid.org/0009-0006-9858-6733"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoyu Li","raw_affiliation_strings":["School of Computer Science, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059269708","display_name":"Zhiqun Zuo","orcid":"https://orcid.org/0000-0001-5469-2725"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqun Zuo","raw_affiliation_strings":["School of Computer Science, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078850933"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13798044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":null,"first_page":"2690","last_page":"2695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6711570024490356},{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.6353424191474915},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6005631685256958},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5963027477264404},{"id":"https://openalex.org/keywords/brightness","display_name":"Brightness","score":0.5621408224105835},{"id":"https://openalex.org/keywords/spots","display_name":"Spots","score":0.5423634052276611},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5078678727149963},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.46039503812789917},{"id":"https://openalex.org/keywords/fish-actinopterygii","display_name":"Fish <Actinopterygii>","score":0.4399903118610382},{"id":"https://openalex.org/keywords/microscope","display_name":"Microscope","score":0.41521352529525757},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.41430261731147766},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.4114904999732971},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2751723527908325},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18372198939323425},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.18314522504806519},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13415122032165527}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6711570024490356},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.6353424191474915},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6005631685256958},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5963027477264404},{"id":"https://openalex.org/C125245961","wikidata":"https://www.wikidata.org/wiki/Q221656","display_name":"Brightness","level":2,"score":0.5621408224105835},{"id":"https://openalex.org/C2781255879","wikidata":"https://www.wikidata.org/wiki/Q7580087","display_name":"Spots","level":2,"score":0.5423634052276611},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5078678727149963},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.46039503812789917},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.4399903118610382},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.41521352529525757},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.41430261731147766},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4114904999732971},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2751723527908325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18372198939323425},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.18314522504806519},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13415122032165527},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm47256.2019.8983204","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm47256.2019.8983204","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W18543265","https://openalex.org/W1974685860","https://openalex.org/W1996846725","https://openalex.org/W1998297552","https://openalex.org/W2005471620","https://openalex.org/W2054814429","https://openalex.org/W2079585084","https://openalex.org/W2117305280","https://openalex.org/W2132817297","https://openalex.org/W2133059825","https://openalex.org/W2141393790","https://openalex.org/W2149908785","https://openalex.org/W2246991854","https://openalex.org/W2387001731","https://openalex.org/W2566376500","https://openalex.org/W2727750196","https://openalex.org/W2766802800","https://openalex.org/W2824392129","https://openalex.org/W6691104823","https://openalex.org/W6758801729"],"related_works":["https://openalex.org/W2138983844","https://openalex.org/W1968965685","https://openalex.org/W2012792772","https://openalex.org/W2356573839","https://openalex.org/W2111883783","https://openalex.org/W2009028679","https://openalex.org/W2357424838","https://openalex.org/W2327601824","https://openalex.org/W4237142086","https://openalex.org/W2161102362"],"abstract_inverted_index":{"Fluorescence":[0],"in":[1,21,82,106],"situ":[2],"hybridization":[3],"(FISH)":[4],"is":[5,42,62],"a":[6,52,83,94,117],"well-recognized":[7],"technique":[8],"for":[9,188],"evaluating":[10],"the":[11,30,35,47,76,98,128,144,159,189],"human":[12],"epidermal":[13],"growth":[14],"factor":[15],"receptor":[16],"2":[17],"(HER2)":[18],"gene":[19],"status":[20],"breast":[22],"cancer,":[23],"where":[24],"HER2":[25,41,122],"genes":[26],"are":[27,44,92],"seen":[28],"as":[29,46],"red":[31],"stained":[32,49],"spots,":[33],"and":[34,65,85,103,123,147,154,173],"chromosome":[36],"centromere":[37],"(CEN17)":[38],"on":[39,73,127],"which":[40],"located":[43],"visible":[45],"green":[48],"spots":[50,81,166],"under":[51],"fluorescent":[53],"microscope.":[54],"The":[55,176],"traditional":[56],"manual":[57],"analysis":[58],"of":[59,79,101,131],"FISH":[60,107,133,191],"images":[61,108,192],"low":[63],"efficient":[64],"has":[66],"great":[67],"subjective":[68],"differences.":[69],"Many":[70],"researches":[71],"focus":[72],"automatically":[74],"calculating":[75],"average":[77],"ratio":[78,151],"red/green":[80,165],"cell":[84],"have":[86,179],"achieved":[87],"good":[88],"performance.":[89],"However,":[90],"there":[91],"still":[93],"need":[95],"to":[96,120,138,142,148,157],"improve":[97],"segmentation":[99],"accuracy":[100],"cells":[102],"HER2/CEN17":[104],"signals":[105,125],"with":[109,193],"poor":[110],"quality.":[111,195],"In":[112],"this":[113],"paper,":[114],"we":[115,136,163],"propose":[116,137],"robust":[118],"approach":[119],"locate":[121],"CEN17":[124],"based":[126],"image":[129],"standardization":[130],"varied":[132],"images.":[134],"First":[135],"use":[139,149],"offset":[140],"operation":[141],"reduce":[143],"fluorescence":[145],"scattering,":[146],"exposure":[150],"map":[152],"estimation":[153],"brightness":[155],"transformation":[156],"enhance":[158],"weak":[160],"fluorescence.":[161],"Then":[162],"detect":[164],"by":[167],"sequentially":[168],"using":[169],"top-hat":[170],"filtering,":[171],"thresholding":[172],"post-processing":[174],"operations.":[175],"experimental":[177],"results":[178],"shown":[180],"that":[181],"our":[182],"proposed":[183],"method":[184],"can":[185],"work":[186],"well":[187],"clinical":[190],"different":[194]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
