{"id":"https://openalex.org/W2914468475","doi":"https://doi.org/10.1109/bibm.2018.8621576","title":"Cantharidin Triggers Apoptosis via ALB and PPP2R4 against Lung Cancer","display_name":"Cantharidin Triggers Apoptosis via ALB and PPP2R4 against Lung Cancer","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2914468475","doi":"https://doi.org/10.1109/bibm.2018.8621576","mag":"2914468475"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621576","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621576","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013506158","display_name":"Guang Zheng","orcid":"https://orcid.org/0000-0003-4118-7804"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guang Zheng","raw_affiliation_strings":["School of Information Science & Engineering, Lanzhou University, Lanzhou, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Information Science & Engineering, Lanzhou University, Lanzhou, P.R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073956681","display_name":"Fei Hou","orcid":"https://orcid.org/0000-0001-8681-5355"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Hou","raw_affiliation_strings":["School of Information Science & Engineering, Lanzhou University, Lanzhou, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Information Science & Engineering, Lanzhou University, Lanzhou, P.R. China","institution_ids":["https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013506158"],"corresponding_institution_ids":["https://openalex.org/I76214153"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17658127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":"2832","last_page":"2836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9354000091552734,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.9212999939918518,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cantharidin","display_name":"Cantharidin","score":0.994783878326416},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.8262021541595459},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5527441501617432},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5378090739250183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.449510395526886},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.42644545435905457},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3420746922492981},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3285970091819763},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2518855631351471},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24921879172325134},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.17191347479820251},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1694636046886444}],"concepts":[{"id":"https://openalex.org/C2780906345","wikidata":"https://www.wikidata.org/wiki/Q410884","display_name":"Cantharidin","level":2,"score":0.994783878326416},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8262021541595459},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5527441501617432},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5378090739250183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.449510395526886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42644545435905457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3420746922492981},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3285970091819763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2518855631351471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24921879172325134},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.17191347479820251},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1694636046886444},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1109/bibm.2018.8621576","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621576","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/282152","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/282152","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Proceedings Paper"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/403816","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/403816","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference article (CA)"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/269240","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/269240","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u4f1a\u8bae\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/281025","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/281025","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Proceedings Paper"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/292862","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/292862","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Proceedings Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1490956705","https://openalex.org/W1532375786","https://openalex.org/W1784980210","https://openalex.org/W1965057088","https://openalex.org/W1996000832","https://openalex.org/W2008842970","https://openalex.org/W2064033136","https://openalex.org/W2096173332","https://openalex.org/W2096541451","https://openalex.org/W2103017472","https://openalex.org/W2106108074","https://openalex.org/W2116704363","https://openalex.org/W2131848047","https://openalex.org/W2158106840","https://openalex.org/W2158217645","https://openalex.org/W2159675211","https://openalex.org/W2179325826","https://openalex.org/W2204695023","https://openalex.org/W2247205839","https://openalex.org/W2294516783","https://openalex.org/W2382935820","https://openalex.org/W2626118169","https://openalex.org/W2729114428","https://openalex.org/W2730024077","https://openalex.org/W2797197823","https://openalex.org/W6674494894"],"related_works":["https://openalex.org/W2333884926","https://openalex.org/W2374788341","https://openalex.org/W2003795585","https://openalex.org/W2046682587","https://openalex.org/W2392160466","https://openalex.org/W2904810194","https://openalex.org/W856668245","https://openalex.org/W2367096380","https://openalex.org/W2391438359","https://openalex.org/W2370128869"],"abstract_inverted_index":{"Cantharidin":[0],"is":[1,40],"a":[2,67,71],"bio-active":[3],"compound":[4],"extracted":[5],"from":[6,28,58],"mylabris":[7],"which":[8],"has":[9],"been":[10,26],"widely":[11],"adopted":[12],"in":[13],"traditional":[14],"Chinese":[15],"medicine":[16],"clinic":[17],"practices":[18],"against":[19,37,53],"lung":[20,38,54],"cancer.":[21],"Although":[22],"apoptosis":[23],"bio-markers":[24,63],"have":[25],"observed":[27,62],"different":[29,32],"experiments":[30],"under":[31],"conditions,":[33],"detailed":[34],"protein-regulation":[35,48,73],"network":[36,49,74],"cancer":[39,55],"still":[41],"not":[42],"clear.":[43],"In":[44],"this":[45,110],"study,":[46],"evidenced":[47],"triggered":[50],"by":[51],"cantharidin":[52,76],"was":[56,77],"constructed":[57],"binding":[59],"proteins":[60],"to":[61,86,88,95,97],"towards":[64],"apoptosis.":[65],"As":[66],"result,":[68],"targeting":[69],"apoptosis,":[70],"succinct":[72],"of":[75],"constructed.":[78],"It":[79],"contains":[80],"two":[81],"regulation":[82,111],"brunches:":[83],"(1)":[84],"bind":[85,94],"ALB":[87],"further":[89,98],"activate":[90],"TP53,":[91],"and":[92,106],"(2)":[93],"PPP2R4":[96],"inhibit":[99],"MYC.":[100],"Primary":[101],"evaluation":[102],"on":[103],"bioinformatics":[104],"analysis":[105],"literature":[107],"also":[108],"support":[109],"network.":[112]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
