{"id":"https://openalex.org/W2913695303","doi":"https://doi.org/10.1109/bibm.2018.8621465","title":"Integrating Gene Expression Data and Pathway Knowledge for In Silico Hypothesis Generation with IMPRes","display_name":"Integrating Gene Expression Data and Pathway Knowledge for In Silico Hypothesis Generation with IMPRes","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2913695303","doi":"https://doi.org/10.1109/bibm.2018.8621465","mag":"2913695303"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621465","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112452050","display_name":"Yuexu Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuexu Jiang","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003943520","display_name":"Duolin Wang","orcid":"https://orcid.org/0000-0003-1649-460X"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duolin Wang","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082428303","display_name":"Dong Xu","orcid":"https://orcid.org/0000-0002-4809-0514"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Xu","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071079252","display_name":"Trupti Joshi","orcid":"https://orcid.org/0000-0001-8944-4924"},"institutions":[{"id":"https://openalex.org/I2800649613","display_name":"University of Missouri Health System","ror":"https://ror.org/03yp8z857","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800649613"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trupti Joshi","raw_affiliation_strings":["Department of Health Management and Informatics, University of Missouri, Columbia, Missouri, USA"],"affiliations":[{"raw_affiliation_string":"Department of Health Management and Informatics, University of Missouri, Columbia, Missouri, USA","institution_ids":["https://openalex.org/I2800649613","https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5112452050"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":null,"apc_paid":null,"fwci":0.0919,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49279078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"102","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.800133466720581},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7572849988937378},{"id":"https://openalex.org/keywords/trace","display_name":"TRACE (psycholinguistics)","score":0.5491096377372742},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.5333881974220276},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46900320053100586},{"id":"https://openalex.org/keywords/data-visualization","display_name":"Data visualization","score":0.45614027976989746},{"id":"https://openalex.org/keywords/web-service","display_name":"Web service","score":0.4317624568939209},{"id":"https://openalex.org/keywords/informatics","display_name":"Informatics","score":0.4176878035068512},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33277779817581177},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.17897379398345947},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13534384965896606},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1131356954574585},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10262063145637512}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.800133466720581},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7572849988937378},{"id":"https://openalex.org/C75291252","wikidata":"https://www.wikidata.org/wiki/Q1315756","display_name":"TRACE (psycholinguistics)","level":2,"score":0.5491096377372742},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.5333881974220276},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46900320053100586},{"id":"https://openalex.org/C172367668","wikidata":"https://www.wikidata.org/wiki/Q6504956","display_name":"Data visualization","level":3,"score":0.45614027976989746},{"id":"https://openalex.org/C35578498","wikidata":"https://www.wikidata.org/wiki/Q193424","display_name":"Web service","level":2,"score":0.4317624568939209},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.4176878035068512},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33277779817581177},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.17897379398345947},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13534384965896606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1131356954574585},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10262063145637512},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2018.8621465","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1556555540","https://openalex.org/W1644724366","https://openalex.org/W1968667083","https://openalex.org/W1972129511","https://openalex.org/W1979996936","https://openalex.org/W2023639434","https://openalex.org/W2030825396","https://openalex.org/W2040847667","https://openalex.org/W2042778855","https://openalex.org/W2063699975","https://openalex.org/W2063928888","https://openalex.org/W2077631777","https://openalex.org/W2079187345","https://openalex.org/W2084294502","https://openalex.org/W2089691349","https://openalex.org/W2096173332","https://openalex.org/W2111862142","https://openalex.org/W2118258530","https://openalex.org/W2118423420","https://openalex.org/W2129466727","https://openalex.org/W2133074013","https://openalex.org/W2136303131","https://openalex.org/W2141485678","https://openalex.org/W2142433339","https://openalex.org/W2163480486","https://openalex.org/W2174632898","https://openalex.org/W2325767305","https://openalex.org/W2423570221","https://openalex.org/W2530896003","https://openalex.org/W2559588208","https://openalex.org/W2592760610","https://openalex.org/W3101256146","https://openalex.org/W6700952663"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867"],"abstract_inverted_index":{"Although":[0],"biologically":[1],"meaningful":[2],"modules":[3],"can":[4,103],"often":[5],"be":[6],"detected":[7],"by":[8],"many":[9],"existing":[10],"informatics":[11],"tools,":[12],"it":[13,70],"is":[14,148],"still":[15],"hard":[16],"to":[17,74,80],"interpret":[18],"or":[19,106],"make":[20],"use":[21],"of":[22],"the":[23,39,61,76],"results":[24],"towards":[25],"in":[26,136],"silico":[27],"hypothesis":[28],"generation":[29],"and":[30,78,85,125,134],"testing.":[31],"To":[32],"address":[33],"this":[34],"gap,":[35],"we":[36,126],"have":[37,99,127],"developed":[38],"IMPRes":[40,102,145],"(Integrative":[41],"MultiOmics":[42],"Pathway":[43],"Resolution)":[44],"algorithm,":[45],"a":[46,54,67,114,151],"new":[47],"step-wise":[48],"active":[49],"pathway":[50],"detection":[51,63],"method":[52],"using":[53],"dynamic":[55],"programming":[56],"approach.":[57],"This":[58],"approach":[59],"enables":[60],"network":[62],"one":[64],"step":[65],"at":[66,154],"time,":[68],"making":[69],"easy":[71],"for":[72],"researchers":[73],"trace":[75],"pathways,":[77],"leading":[79],"more":[81,86],"accurate":[82],"drug":[83],"design":[84],"effective":[87],"treatment":[88],"strategies.":[89],"The":[90],"evaluation":[91],"experiments":[92],"conducted":[93],"on":[94,117,131],"two":[95],"yeast":[96],"data":[97,121],"sets":[98],"shown":[100],"that":[101],"achieve":[104],"competitive":[105],"better":[107],"performance":[108],"than":[109],"other":[110],"state-of-the-art":[111],"methods.":[112],"Furthermore,":[113],"case":[115],"study":[116],"human":[118],"lung":[119,137],"cancer":[120],"set":[122],"was":[123],"performed":[124],"provided":[128],"several":[129],"insights":[130],"involved":[132],"genes":[133],"mechanisms":[135],"cancer,":[138],"which":[139],"had":[140],"not":[141],"been":[142],"discovered":[143],"earlier.":[144],"visualization":[146],"tool":[147],"available":[149],"as":[150],"web":[152],"service":[153],"http://digbio.missouri.edu/impres.":[155]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}