{"id":"https://openalex.org/W2911565999","doi":"https://doi.org/10.1109/bibm.2018.8621306","title":"A study of feasibility for genome-wide haplotype association of complex traits in imaging genetics","display_name":"A study of feasibility for genome-wide haplotype association of complex traits in imaging genetics","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2911565999","doi":"https://doi.org/10.1109/bibm.2018.8621306","mag":"2911565999"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621306","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621306","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061641831","display_name":"Slim Karkar","orcid":"https://orcid.org/0000-0003-0501-3137"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Slim Karkar","raw_affiliation_strings":["Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001165057","display_name":"Yann Le Guen","orcid":"https://orcid.org/0000-0001-6649-8364"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yann Le Guen","raw_affiliation_strings":["Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067964964","display_name":"Cathy Philippe","orcid":"https://orcid.org/0000-0002-3262-4390"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cathy Philippe","raw_affiliation_strings":["Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045616257","display_name":"Claire Dandine\u2010Roulland","orcid":"https://orcid.org/0000-0002-3340-2001"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210085925","display_name":"Centre National de Recherche en G\u00e9nomique Humaine","ror":"https://ror.org/004yvsb77","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2738703131","https://openalex.org/I2738703131","https://openalex.org/I4210085925","https://openalex.org/I4210113668","https://openalex.org/I4405259120"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Dandine-Roulland","raw_affiliation_strings":["CNRGH, Universit Paris-Saclay, Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRGH, Universit Paris-Saclay, Evry, France","institution_ids":["https://openalex.org/I4210085925","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059396361","display_name":"Morgane Pierre\u2010Jean","orcid":"https://orcid.org/0000-0002-9133-780X"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210085925","display_name":"Centre National de Recherche en G\u00e9nomique Humaine","ror":"https://ror.org/004yvsb77","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2738703131","https://openalex.org/I2738703131","https://openalex.org/I4210085925","https://openalex.org/I4210113668","https://openalex.org/I4405259120"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Morgane Pierre-Jean","raw_affiliation_strings":["CNRGH, Universit Paris-Saclay, Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRGH, Universit Paris-Saclay, Evry, France","institution_ids":["https://openalex.org/I4210085925","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035699131","display_name":"Jean\u2010Fran\u00e7ois Mangin","orcid":"https://orcid.org/0000-0002-1612-461X"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-FranCois Mangin","raw_affiliation_strings":["Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025957487","display_name":"\u00c9dith Le Floch","orcid":"https://orcid.org/0000-0001-8365-9529"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210085925","display_name":"Centre National de Recherche en G\u00e9nomique Humaine","ror":"https://ror.org/004yvsb77","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2738703131","https://openalex.org/I2738703131","https://openalex.org/I4210085925","https://openalex.org/I4210113668","https://openalex.org/I4405259120"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edith Le Floch","raw_affiliation_strings":["CNRGH, Universit Paris-Saclay, Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRGH, Universit Paris-Saclay, Evry, France","institution_ids":["https://openalex.org/I4210085925","https://openalex.org/I277688954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078842273","display_name":"Vincent Frouin","orcid":"https://orcid.org/0000-0001-9360-6623"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Frouin","raw_affiliation_strings":["Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurospin, Universit Paris-Saclay, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I277688954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"562","issue":null,"first_page":"2764","last_page":"2766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9391000270843506,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.8362525701522827},{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.7252165079116821},{"id":"https://openalex.org/keywords/imaging-genetics","display_name":"Imaging genetics","score":0.6972633600234985},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.47467470169067383},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.45215392112731934},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.4299890995025635},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42387065291404724},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.3606123924255371},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3237510323524475},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.3006802201271057},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.18701955676078796},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1674872636795044},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.15714773535728455},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1028311550617218}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.8362525701522827},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.7252165079116821},{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.6972633600234985},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.47467470169067383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45215392112731934},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4299890995025635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42387065291404724},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3606123924255371},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3237510323524475},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3006802201271057},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.18701955676078796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1674872636795044},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.15714773535728455},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1028311550617218}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm.2018.8621306","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621306","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:HAL:cea-02016635v1","is_oa":false,"landing_page_url":"https://cea.hal.science/cea-02016635","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BIBM 2018 - Proceedings of The IEEE International Conference on Bioinformatics and Biomedicine, Dec 2018, Madrid, Spain","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1999945947","https://openalex.org/W2054968856","https://openalex.org/W2098272018","https://openalex.org/W2605704940","https://openalex.org/W2769525786","https://openalex.org/W2791372830","https://openalex.org/W2885059171","https://openalex.org/W2895486342","https://openalex.org/W2950519955"],"related_works":["https://openalex.org/W1971424770","https://openalex.org/W2111842731","https://openalex.org/W2066467839","https://openalex.org/W2594299395","https://openalex.org/W2765794416","https://openalex.org/W2170506381","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W2794350630","https://openalex.org/W2089097350"],"abstract_inverted_index":{"Imaging-genetics":[0],"cohorts":[1],"allow":[2],"to":[3,17,114],"find":[4],"associations":[5],"between":[6],"genotyped":[7],"variants":[8],"and":[9,23,33,49,106],"brain":[10,27],"imaging":[11],"features.":[12],"They":[13],"are":[14,62,79],"invaluable":[15],"tools":[16],"evaluate":[18],"the":[19,26,42,82],"part":[20],"of":[21,59,76,85,94],"genetics":[22],"environment":[24],"in":[25,31],"characteristic":[28],"variance":[29],"observed":[30],"normal":[32],"pathological":[34],"populations.":[35],"The":[36,88],"present":[37],"analyses":[38],"were":[39],"conducted":[40],"using":[41,67,81],"2018":[43],"UK":[44,86],"Biobank":[45],"(UKB)":[46],"data":[47],"release,":[48],"included":[50],"15,040":[51],"subjects":[52],"for":[53,64],"which":[54],"sulcal":[55],"opening,":[56],"a":[57,102],"measure":[58],"sulcus":[60],"width,":[61],"extracted":[63,80],"126":[65],"sulci":[66],"BrainVisa/Morphologist":[68],"pipeline.":[69],"Based":[70],"on":[71,97],"genetic":[72],"maps,":[73],"continuous":[74],"blocks":[75,96],"high-confidence":[77],"phase":[78],"haplotype":[83],"dataset":[84],"Biobank.":[87],"feasibility":[89],"study":[90],"analyzes":[91],"13,942":[92],"haplotypes":[93],"1,756":[95],"chromosome":[98],"21,":[99],"obtained":[100],"with":[101],"stringent":[103],"block":[104],"definition,":[105],"shows":[107],"that":[108],"block-based":[109],"test":[110],"seems":[111],"underpowered":[112],"compared":[113],"haplotype-based":[115],"association":[116],"test.":[117]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}