{"id":"https://openalex.org/W2912029475","doi":"https://doi.org/10.1109/bibm.2018.8621227","title":"Genome-Wide miRNA Expression Alterations in Nucleus Accumbens Provide Insights into Chronic Stress and Treatment in Depression","display_name":"Genome-Wide miRNA Expression Alterations in Nucleus Accumbens Provide Insights into Chronic Stress and Treatment in Depression","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2912029475","doi":"https://doi.org/10.1109/bibm.2018.8621227","mag":"2912029475"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621227","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621227","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002294425","display_name":"Weichen Song","orcid":"https://orcid.org/0000-0003-3197-6236"},"institutions":[{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weichen Song","raw_affiliation_strings":["Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047609717","display_name":"Guan Ning Lin","orcid":"https://orcid.org/0000-0001-9496-0149"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guan Ning Lin","raw_affiliation_strings":["School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112383520","display_name":"Sufang Peng","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sufang Peng","raw_affiliation_strings":["Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100671490","display_name":"Yanhua Zhang","orcid":"https://orcid.org/0000-0002-3820-5939"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhua Zhang","raw_affiliation_strings":["Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073578726","display_name":"Yifeng Shen","orcid":"https://orcid.org/0000-0002-3298-6682"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifeng Shen","raw_affiliation_strings":["Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101549397","display_name":"Huafang Li","orcid":"https://orcid.org/0000-0002-4357-7614"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huafang Li","raw_affiliation_strings":["Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060013340","display_name":"Shunying Yu","orcid":"https://orcid.org/0000-0001-7929-204X"},"institutions":[{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunying Yu","raw_affiliation_strings":["Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5002294425"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802690428"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17378348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":null,"first_page":"142","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.805077314376831},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"Nucleus accumbens","score":0.7657644152641296},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6870151162147522},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5085881948471069},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4851844906806946},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.44782179594039917},{"id":"https://openalex.org/keywords/antidepressant","display_name":"Antidepressant","score":0.440322607755661},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4402436316013336},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38948577642440796},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3416889011859894},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29378801584243774},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.17044800519943237},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.13479545712471008},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.07205402851104736},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.06898483633995056}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.805077314376831},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.7657644152641296},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6870151162147522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5085881948471069},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4851844906806946},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.44782179594039917},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.440322607755661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4402436316013336},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38948577642440796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3416889011859894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29378801584243774},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.17044800519943237},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.13479545712471008},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.07205402851104736},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06898483633995056},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2018.8621227","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621227","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1766279608","https://openalex.org/W1966327575","https://openalex.org/W1971061160","https://openalex.org/W1981654563","https://openalex.org/W1996154318","https://openalex.org/W2034692527","https://openalex.org/W2058337598","https://openalex.org/W2071815275","https://openalex.org/W2077327925","https://openalex.org/W2103017472","https://openalex.org/W2104261628","https://openalex.org/W2119034410","https://openalex.org/W2132165603","https://openalex.org/W2134629862","https://openalex.org/W2148855381","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2269261154","https://openalex.org/W2314624240","https://openalex.org/W2353111961","https://openalex.org/W2412227306","https://openalex.org/W2413836758","https://openalex.org/W2430804118","https://openalex.org/W2521928463","https://openalex.org/W2596957891","https://openalex.org/W2740994409","https://openalex.org/W2751700789","https://openalex.org/W2758366693","https://openalex.org/W2795952060","https://openalex.org/W2797222068","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W1964572291","https://openalex.org/W4387948744","https://openalex.org/W184793361","https://openalex.org/W2352732738","https://openalex.org/W2123060905","https://openalex.org/W2008413772","https://openalex.org/W2559588208","https://openalex.org/W2063238667","https://openalex.org/W4318778067","https://openalex.org/W1923384484"],"abstract_inverted_index":{"Nucleus":[0,62],"Accumbens":[1,63],"(NAc)":[2],"is":[3],"a":[4,16,122,146,150,162],"key":[5],"area":[6],"for":[7],"reward":[8],"and":[9,13,32,56,76,89,133,158,186,206,222,247],"response":[10,249],"to":[11,49],"stress,":[12],"microRNA":[14],"plays":[15],"critical":[17],"role":[18],"in":[19,26,108,191,212,234],"depression.":[20,213,252],"However,":[21],"the":[22,29],"miRNA":[23,99,224],"expression":[24,74,80],"alteration":[25],"NAc":[27,223],"during":[28],"stress-induced":[30,251],"depression":[31],"antidepressant":[33,237],"treatment,":[34],"as":[35,37],"well":[36],"its":[38,209],"biological":[39],"significance,":[40],"remains":[41],"mostly":[42],"unexplored.":[43],"We":[44,71,120],"randomly":[45],"selected":[46],"24":[47],"rats":[48,65],"control,":[50],"chronic":[51,228],"unpredictable":[52],"mild":[53],"stress":[54,155,235],"(CUMS)":[55],"CUMS+Escitalopram":[57],"treatment":[58,114,205,216,248],"group":[59],"(8":[60],"each).":[61],"of":[64,116,172,181,184,195,199,250],"from":[66],"3":[67],"groups":[68],"were":[69,92,231],"microRNA-sequenced.":[70],"applied":[72],"differential":[73,96],"analysis":[75,91,144,180],"co-expression":[77,143],"analyses":[78],"on":[79],"data.":[81],"After":[82],"target":[83,197],"gene":[84],"prediction":[85],"by":[86,227],"Targetscan,":[87],"network":[88],"pathway":[90,179,194,241],"also":[93],"performed.":[94],"18/8":[95],"expressing":[97],"(DE)":[98],"(FDR":[100],"<;0.05,":[101],"log2FC":[102],">1":[103],"or":[104],"<;-1)":[105],"are":[106,118],"observed":[107,121],"control":[109],"VS":[110,113],"case/":[111],"case":[112],"comparison,2":[115],"them":[117],"overlapping.":[119],"negative":[123],"correlation":[124,153,164],"between":[125],"log":[126,134],"<sub":[127,135],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[128,136],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sub>":[129,137],"FC(control":[130],"vs.":[131,140],"case)":[132],"FC":[138],"(case":[139],"treatment).":[141],"Weighted":[142],"discovered":[145],"module":[147],"(M1)":[148],"with":[149,154,161,165,202],"strong":[151],"positive":[152,163],"(R=0.96,":[156],"P=0.003),":[157],"another":[159],"module(M7)":[160],"anhedonia":[166],"(R=0.89,":[167],"P=0.02).":[168],"In":[169],"miRNA-mRNA":[170],"networks":[171],"M1,":[173],"TFRC":[174,230],"had":[175],"most":[176],"neighbors.":[177],"Strikingly,":[178],"Kyoto":[182],"encyclopedia":[183],"genes":[185,198],"genomes":[187],"(KEGG)":[188],"reveals":[189],"enrichment":[190],"Ras":[192],"signaling":[193],"predicted":[196],"miRNAs":[200],"associated":[201],"both":[203,220,244],"depression,":[204],"anhedonia.":[207],"indicating":[208],"potential":[210],"involvement":[211],"Conclusion:":[214],"Escitalopram":[215],"can":[217],"significantly":[218],"reverse":[219],"behavioral":[221],"abnormality":[225],"caused":[226],"stress.":[229],"strongly":[232],"regulated":[233],"and/or":[236],"treatment.":[238],"The":[239],"Ras-signaling":[240],"may":[242],"influence":[243],"onset,":[245],"symptom":[246]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
