{"id":"https://openalex.org/W2914865130","doi":"https://doi.org/10.1109/bibm.2018.8621194","title":"Renal cell carcinoma classification: a case study of pitfalls associated with metabolic landscape analysis","display_name":"Renal cell carcinoma classification: a case study of pitfalls associated with metabolic landscape analysis","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2914865130","doi":"https://doi.org/10.1109/bibm.2018.8621194","mag":"2914865130"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621194","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621194","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079773178","display_name":"Krzysztof Gogolewski","orcid":"https://orcid.org/0000-0001-5523-5198"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Krzysztof Gogolewski","raw_affiliation_strings":["Institute of Informatics, University of Warsaw, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Informatics, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039674018","display_name":"Marcin Kostecki","orcid":null},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Kostecki","raw_affiliation_strings":["Institute of Informatics, University of Warsaw, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Informatics, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071617273","display_name":"Anna Gambin","orcid":"https://orcid.org/0000-0003-3476-3017"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Gambin","raw_affiliation_strings":["Institute of Informatics, University of Warsaw, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Informatics, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079773178"],"corresponding_institution_ids":["https://openalex.org/I4654613"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13815383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"96","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6761681437492371},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"Renal cell carcinoma","score":0.6524001359939575},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.6001565456390381},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4394851624965668},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.4364723861217499},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3878173530101776},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34996500611305237},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33461642265319824},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25258347392082214},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21808210015296936},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17696377635002136}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6761681437492371},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6524001359939575},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.6001565456390381},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4394851624965668},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4364723861217499},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3878173530101776},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34996500611305237},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33461642265319824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25258347392082214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21808210015296936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17696377635002136},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2018.8621194","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621194","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/1","score":0.7599999904632568,"display_name":"No poverty"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1173721425","https://openalex.org/W1834683238","https://openalex.org/W1964545175","https://openalex.org/W1989859921","https://openalex.org/W2042950203","https://openalex.org/W2046254395","https://openalex.org/W2070817546","https://openalex.org/W2078355959","https://openalex.org/W2079969839","https://openalex.org/W2096982692","https://openalex.org/W2133067229","https://openalex.org/W2135874673","https://openalex.org/W2139368593","https://openalex.org/W2154061034","https://openalex.org/W2158312129","https://openalex.org/W2158751220","https://openalex.org/W2166098345","https://openalex.org/W2170974939","https://openalex.org/W2272272265","https://openalex.org/W2417207939","https://openalex.org/W2418056440","https://openalex.org/W2521222592","https://openalex.org/W2592138095","https://openalex.org/W2609372940","https://openalex.org/W2624701078","https://openalex.org/W2782130264","https://openalex.org/W2950497661","https://openalex.org/W6640982676","https://openalex.org/W6679540703"],"related_works":["https://openalex.org/W2136583354","https://openalex.org/W2111238207","https://openalex.org/W2760721665","https://openalex.org/W330130819","https://openalex.org/W2288610023","https://openalex.org/W2112044895","https://openalex.org/W3121416282","https://openalex.org/W2281389338","https://openalex.org/W2037453743","https://openalex.org/W4312222450"],"abstract_inverted_index":{"The":[0,22],"huge":[1],"amount":[2],"of":[3,43,63,76,86,89,98,108,122],"biological":[4],"data":[5,20,45,124],"gained":[6],"from":[7,120],"many":[8],"different":[9],"sources":[10],"opens":[11],"up":[12],"new":[13],"possibilities":[14],"alongside":[15],"with":[16,41,46,125],"some":[17],"dangers":[18],"in":[19,103],"integration.":[21],"latter":[23],"are":[24,92],"not":[25],"so":[26],"widely":[27],"taken":[28],"account":[29],"for.":[30],"In":[31,69,132],"the":[32,64,106,116,140],"present":[33],"article,":[34],"we":[35,71],"show":[36],"what":[37],"problems":[38],"may":[39,137],"arise":[40],"integration":[42,121],"metabolomic":[44],"gene":[47],"expression":[48],"datasets.":[49],"We":[50],"analyze":[51],"common":[52,95],"pitfalls":[53],"and":[54,81],"provide":[55,72],"solutions,":[56],"exemplifying":[57],"them":[58],"by":[59,94],"a":[60,73,83],"case":[61],"study":[62],"renal":[65],"cell":[66],"carcinoma":[67],"(RCC).":[68],"particular":[70],"metabolic":[74],"description":[75],"known":[77],"morphological":[78],"RCC":[79],"subtypes":[80],"suggest":[82],"possible":[84],"existence":[85],"poor-prognosis":[87],"cluster":[88],"patients,":[90],"which":[91],"characterized":[93],"low":[96],"activity":[97],"drug":[99],"transporting":[100],"enzymes":[101],"important":[102],"chemotherapy.":[104],"Finally,":[105],"goal":[107],"this":[109],"work":[110],"is":[111],"also":[112],"to":[113],"point":[114],"out":[115],"problem":[117],"that":[118],"arises":[119],"high-throughput":[123],"inherently":[126],"biased":[127],"manually":[128],"curated":[129],"low-throughput":[130],"data.":[131],"such":[133],"cases":[134],"overrepresented":[135],"information":[136],"potentially":[138],"overshadow":[139],"non-trivial":[141],"discoveries.":[142]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}