{"id":"https://openalex.org/W2914501008","doi":"https://doi.org/10.1109/bibm.2018.8621159","title":"Hierarchical Recurrent Convolutional Neural Network for Chemical-protein Relation Extraction from Biomedical Literature","display_name":"Hierarchical Recurrent Convolutional Neural Network for Chemical-protein Relation Extraction from Biomedical Literature","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2914501008","doi":"https://doi.org/10.1109/bibm.2018.8621159","mag":"2914501008"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621159","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621159","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102828553","display_name":"Cong Sun","orcid":"https://orcid.org/0000-0003-0240-1070"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cong Sun","raw_affiliation_strings":["College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051597671","display_name":"Zhihao Yang","orcid":"https://orcid.org/0000-0001-6186-2024"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihao Yang","raw_affiliation_strings":["College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100736263","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0002-8420-6860"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Beijing Institute of Health Administration and Medical Information, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Beijing Institute of Health Administration and Medical Information, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343737","display_name":"Yin Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Zhang","raw_affiliation_strings":["Beijing Institute of Health Administration and Medical Information, Beijing, China","College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"Beijing Institute of Health Administration and Medical Information, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023931221","display_name":"Hongfei Lin","orcid":"https://orcid.org/0000-0003-0872-7688"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongfei Lin","raw_affiliation_strings":["College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768936","display_name":"Jian Wang","orcid":"https://orcid.org/0000-0002-0393-3709"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101857032","display_name":"Liang Yang","orcid":"https://orcid.org/0000-0003-3396-575X"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Yang","raw_affiliation_strings":["College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100737914","display_name":"Kan Xu","orcid":"https://orcid.org/0000-0001-6954-2578"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kan Xu","raw_affiliation_strings":["College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046020427","display_name":"Yijia Zhang","orcid":"https://orcid.org/0000-0002-5843-4675"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijia Zhang","raw_affiliation_strings":["Beijing Institute of Health Administration and Medical Information, Beijing, China","College of Computer Science and Technology, Dalian University of Technology, Dalian, China"],"affiliations":[{"raw_affiliation_string":"Beijing Institute of Health Administration and Medical Information, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"College of Computer Science and Technology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5102828553"],"corresponding_institution_ids":["https://openalex.org/I27357992"],"apc_list":null,"apc_paid":null,"fwci":0.3677,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.61213347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"1","issue":null,"first_page":"765","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13083","display_name":"Advanced Text Analysis Techniques","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7846482992172241},{"id":"https://openalex.org/keywords/recurrent-neural-network","display_name":"Recurrent neural network","score":0.6534252166748047},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6407956480979919},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6370715498924255},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6298573017120361},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.582874596118927},{"id":"https://openalex.org/keywords/relation","display_name":"Relation (database)","score":0.5435441136360168},{"id":"https://openalex.org/keywords/relationship-extraction","display_name":"Relationship extraction","score":0.5246908068656921},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.5178394913673401},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.47449991106987},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.43374019861221313},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.37601834535598755},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3427502512931824},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.23994937539100647},{"id":"https://openalex.org/keywords/information-extraction","display_name":"Information extraction","score":0.2369137704372406}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7846482992172241},{"id":"https://openalex.org/C147168706","wikidata":"https://www.wikidata.org/wiki/Q1457734","display_name":"Recurrent neural network","level":3,"score":0.6534252166748047},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6407956480979919},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6370715498924255},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6298573017120361},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.582874596118927},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.5435441136360168},{"id":"https://openalex.org/C153604712","wikidata":"https://www.wikidata.org/wiki/Q7310755","display_name":"Relationship extraction","level":3,"score":0.5246908068656921},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5178394913673401},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.47449991106987},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.43374019861221313},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.37601834535598755},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3427502512931824},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.23994937539100647},{"id":"https://openalex.org/C195807954","wikidata":"https://www.wikidata.org/wiki/Q1662562","display_name":"Information extraction","level":2,"score":0.2369137704372406},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2018.8621159","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621159","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4","score":0.7900000214576721}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2809349863","https://openalex.org/W2883380892","https://openalex.org/W2883749461"],"related_works":["https://openalex.org/W2976808399","https://openalex.org/W2609844752","https://openalex.org/W2981341912","https://openalex.org/W4285246823","https://openalex.org/W4226278302","https://openalex.org/W4221160509","https://openalex.org/W2547211086","https://openalex.org/W2538200646","https://openalex.org/W2888033806","https://openalex.org/W4385734297"],"abstract_inverted_index":{"Extracting":[0],"chemical-protein":[1,31],"relations":[2],"between":[3],"chemicals":[4],"and":[5,59,100],"proteins":[6],"plays":[7],"a":[8,65],"key":[9],"role":[10],"in":[11],"various":[12],"biomedical":[13],"tasks,":[14],"such":[15],"as":[16,21,23],"drug":[17],"discovery,":[18],"precision":[19],"medicine,":[20],"well":[22],"clinical":[24],"research.":[25],"Most":[26],"popular":[27],"methods":[28],"for":[29],"the":[30,42,88,102],"interaction":[32],"(CHEMPROT)":[33],"task":[34],"are":[35,53],"based":[36],"on":[37,87],"neural":[38,70],"networks":[39],"to":[40,57,75],"avoid":[41],"complex":[43],"hand-crafted":[44],"features":[45,79],"derived":[46],"from":[47,80],"linguistic":[48],"analyses.":[49],"However,":[50],"their":[51],"performances":[52],"usually":[54],"limited":[55],"due":[56],"long":[58],"complicated":[60],"sentences.":[61],"Therefore,":[62],"we":[63],"propose":[64],"novel":[66],"hierarchical":[67],"recurrent":[68],"convolutional":[69],"network":[71],"(Hierarchical":[72],"RCNN)-based":[73],"approach":[74],"efficiently":[76],"learn":[77],"latent":[78],"short":[81],"context":[82],"subsequences.":[83],"The":[84],"experimental":[85],"results":[86],"CHEMPROT":[89],"corpus":[90],"show":[91],"that":[92],"our":[93],"method":[94],"achieves":[95],"an":[96],"F-score":[97],"of":[98],"65.56%,":[99],"outperforms":[101],"state-of-the-art":[103],"systems.":[104]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}