{"id":"https://openalex.org/W2912236307","doi":"https://doi.org/10.1109/bibm.2018.8621103","title":"Multipath2vec: Predicting Pathogenic Genes via Heterogeneous Network Embedding","display_name":"Multipath2vec: Predicting Pathogenic Genes via Heterogeneous Network Embedding","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2912236307","doi":"https://doi.org/10.1109/bibm.2018.8621103","mag":"2912236307"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621103","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621103","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022604762","display_name":"Bo Xu","orcid":"https://orcid.org/0000-0003-4135-0683"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Xu","raw_affiliation_strings":["Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345976","display_name":"Yu Liu","orcid":"https://orcid.org/0009-0007-6599-5685"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Liu","raw_affiliation_strings":["School of Software, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Software, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004781883","display_name":"Shuo Yu","orcid":"https://orcid.org/0000-0003-1124-9509"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuo Yu","raw_affiliation_strings":["School of Software, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Software, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100710637","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0002-5065-8447"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349606","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0002-9995-9080"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023931221","display_name":"Hongfei Lin","orcid":"https://orcid.org/0000-0003-0872-7688"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongfei Lin","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051597671","display_name":"Zhihao Yang","orcid":"https://orcid.org/0000-0001-6186-2024"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihao Yang","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370493","display_name":"Jian Wang","orcid":"https://orcid.org/0000-0002-8116-7691"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089615958","display_name":"Feng Xia","orcid":"https://orcid.org/0000-0002-8324-1859"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Xia","raw_affiliation_strings":["Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory for Ubiquitious Network and Service Software of Liaoning, Dalian University of Technology, China","institution_ids":["https://openalex.org/I27357992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5022604762"],"corresponding_institution_ids":["https://openalex.org/I27357992"],"apc_list":null,"apc_paid":null,"fwci":0.1838,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54249174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":null,"first_page":"951","last_page":"956"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.7885076403617859},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7210568189620972},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5531953573226929},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.5139366984367371},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4514271020889282},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.44262075424194336},{"id":"https://openalex.org/keywords/heterogeneous-network","display_name":"Heterogeneous network","score":0.42509427666664124},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4130250811576843},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4040508568286896},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3798803687095642},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20642608404159546},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18062013387680054}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7885076403617859},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7210568189620972},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5531953573226929},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.5139366984367371},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4514271020889282},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.44262075424194336},{"id":"https://openalex.org/C158207573","wikidata":"https://www.wikidata.org/wiki/Q5747224","display_name":"Heterogeneous network","level":4,"score":0.42509427666664124},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4130250811576843},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4040508568286896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3798803687095642},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20642608404159546},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18062013387680054},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C108037233","wikidata":"https://www.wikidata.org/wiki/Q11375","display_name":"Wireless network","level":3,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2018.8621103","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621103","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2038122249","https://openalex.org/W2065615506","https://openalex.org/W2097498614","https://openalex.org/W2097660065","https://openalex.org/W2100582962","https://openalex.org/W2103478816","https://openalex.org/W2104261859","https://openalex.org/W2154654747","https://openalex.org/W2154851992","https://openalex.org/W2168909179","https://openalex.org/W2537013382","https://openalex.org/W2556858158","https://openalex.org/W2560074596","https://openalex.org/W2612755257","https://openalex.org/W2621376558","https://openalex.org/W2743104969","https://openalex.org/W2756551540","https://openalex.org/W2765090334","https://openalex.org/W2799012401","https://openalex.org/W2804186728","https://openalex.org/W2804558096","https://openalex.org/W2808272687","https://openalex.org/W3104097132","https://openalex.org/W6675778768","https://openalex.org/W6684463743","https://openalex.org/W6737426376","https://openalex.org/W6739325163"],"related_works":["https://openalex.org/W2081900870","https://openalex.org/W1927327903","https://openalex.org/W1544665982","https://openalex.org/W2022479666","https://openalex.org/W2805504328","https://openalex.org/W2183306018","https://openalex.org/W2549990292","https://openalex.org/W2345479200","https://openalex.org/W2951819827","https://openalex.org/W2849310602"],"abstract_inverted_index":{"Phenotypically":[0],"similar":[1],"diseases":[2],"have":[3],"been":[4],"verified":[5],"to":[6,84,92,109,147,167],"be":[7],"in":[8,18,88,90,173,193],"connection":[9],"with":[10],"specific":[11],"genes.":[12,176],"Predicting":[13],"disease":[14,19],"genes":[15,37,62,117,196],"is":[16,53,82,163],"important":[17],"prevention,":[20],"diagnosis,":[21],"and":[22,33,63,72,107,111,118,133,142],"treatment.":[23],"In":[24],"this":[25,30,162],"work,":[26],"we":[27,43,77,98],"focus":[28],"on":[29,56,135,185],"significant":[31],"issue":[32],"propose":[34,78],"a":[35],"disease-causing":[36,195],"prediction":[38],"method":[39,172],"called":[40,48],"Multipath2vec.":[41],"First,":[42],"generate":[44],"an":[45],"heterogeneous":[46,169],"network":[47,170,190],"GP":[49],"-":[50],"network,":[51],"which":[52,81],"constructed":[54],"based":[55],"three":[57],"kinds":[58],"of":[59,104,181,188],"relationships":[60],"between":[61,67,70,115],"phenotypes,":[64,71],"including":[65],"interactions":[66],"genes,":[68],"correlations":[69],"known":[73],"gene-phenotype":[74,137,140,144],"pairs.":[75],"Then,":[76],"the":[79,95,100,113,119,164,186,194],"multi-path,":[80],"used":[83],"guide":[85],"random":[86],"walk":[87],"GP-network":[89],"order":[91],"better":[93,153],"embedding":[94,171],"network.":[96],"Finally,":[97],"use":[99,168],"achieved":[101],"vector":[102],"representation":[103,191],"each":[105],"protein":[106],"phenotype":[108],"calculate":[110],"rank":[112],"similarities":[114],"candidate":[116],"target":[120],"phenotype.":[121],"We":[122],"implement":[123],"Multipath2vec":[124,151,182],"as":[125,127],"well":[126],"two":[128],"baseline":[129,156],"approaches":[130],"(i.e.,":[131],"CATAPULT,":[132],"PRINCE)":[134],"whole":[136],"data,":[138,141],"single-gene":[139],"many-genes":[143],"data.":[145],"According":[146],"leave-one-out":[148],"cross":[149],"validation,":[150],"achieves":[152],"results":[154,180],"than":[155],"approaches.":[157],"To":[158],"our":[159],"best":[160],"knowledge,":[161],"first":[165],"attempt":[166],"handling":[174],"pathogenic":[175],"The":[177],"outperformed":[178],"experimental":[179],"shed":[183],"light":[184],"possibility":[187],"applying":[189],"methods":[192],"prediction.":[197]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}