{"id":"https://openalex.org/W2912135003","doi":"https://doi.org/10.1109/bibm.2018.8621087","title":"A Gene Family-led Meta-Analysis of Drug-Target Interactions","display_name":"A Gene Family-led Meta-Analysis of Drug-Target Interactions","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2912135003","doi":"https://doi.org/10.1109/bibm.2018.8621087","mag":"2912135003"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2018.8621087","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068224540","display_name":"Qiong Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiong Cheng","raw_affiliation_strings":["Department of Computer Science, University of North Carolina, Charlotte, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of North Carolina, Charlotte, NC, USA","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049305933","display_name":"Saurabh Mehta","orcid":"https://orcid.org/0000-0002-9174-128X"},"institutions":[{"id":"https://openalex.org/I863896202","display_name":"Delhi Technological University","ror":"https://ror.org/01ztcvt22","country_code":"IN","type":"education","lineage":["https://openalex.org/I863896202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saurabh Mehta","raw_affiliation_strings":["Department of Applied Chemistry, Delhi Technological University, Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Delhi Technological University, Delhi, India","institution_ids":["https://openalex.org/I863896202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013636406","display_name":"Stephan C. Sch\u00fcrer","orcid":"https://orcid.org/0000-0001-7180-0978"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan Schurer","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, University of Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.429,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.68214902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"40","issue":null,"first_page":"1618","last_page":"1623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.965399980545044,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5386571288108826},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4298713207244873},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18457797169685364},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1426476538181305}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5386571288108826},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4298713207244873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18457797169685364},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1426476538181305}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2018.8621087","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2018.8621087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W98897677","https://openalex.org/W1530167222","https://openalex.org/W1544009106","https://openalex.org/W1599749096","https://openalex.org/W1968682237","https://openalex.org/W1970263201","https://openalex.org/W1972821149","https://openalex.org/W1982888190","https://openalex.org/W1984084871","https://openalex.org/W1984694945","https://openalex.org/W1986425243","https://openalex.org/W1995996719","https://openalex.org/W2001415793","https://openalex.org/W2011138994","https://openalex.org/W2012034410","https://openalex.org/W2018518196","https://openalex.org/W2022609682","https://openalex.org/W2024908724","https://openalex.org/W2033591223","https://openalex.org/W2034475831","https://openalex.org/W2036251618","https://openalex.org/W2039490407","https://openalex.org/W2055572452","https://openalex.org/W2056499061","https://openalex.org/W2057625601","https://openalex.org/W2060109055","https://openalex.org/W2063149926","https://openalex.org/W2070789802","https://openalex.org/W2099426422","https://openalex.org/W2110595429","https://openalex.org/W2113638222","https://openalex.org/W2122995608","https://openalex.org/W2130956106","https://openalex.org/W2134845483","https://openalex.org/W2138512826","https://openalex.org/W2139163604","https://openalex.org/W2139510803","https://openalex.org/W2139516171","https://openalex.org/W2144086069","https://openalex.org/W2146416540","https://openalex.org/W2147418473","https://openalex.org/W2153341679","https://openalex.org/W2153838454","https://openalex.org/W2154896031","https://openalex.org/W2159092541","https://openalex.org/W2159675211","https://openalex.org/W2162011385","https://openalex.org/W2166523933","https://openalex.org/W2170146596","https://openalex.org/W2171955717","https://openalex.org/W2397834228","https://openalex.org/W2409439195","https://openalex.org/W2417164861","https://openalex.org/W2492990009","https://openalex.org/W2539985226","https://openalex.org/W2558217333","https://openalex.org/W2599371988","https://openalex.org/W2604190529","https://openalex.org/W2772309359","https://openalex.org/W2774226075","https://openalex.org/W2952200877","https://openalex.org/W6604018965","https://openalex.org/W6730118541"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"The":[0,138,163],"shift":[1],"from":[2,42,68],"\u201cmagic":[3,6,62],"bullets\u201d":[4],"to":[5,25,94,169],"shotguns\u201d":[7,63],"has":[8],"prospered":[9],"the":[10,32,43,61,72,81,106,109,131,143,151,158,180,183],"pharmaceutical":[11],"industry,":[12],"where":[13],"a":[14,18,26,46,50,116,177],"belief":[15],"is":[16,91],"that":[17,123],"drug":[19,48],"that\u201dhits\u201d":[20],"multiple":[21,53],"sensitive":[22],"nodes":[23],"belonging":[24],"network":[27],"of":[28,45,52,83,135,145,154,160,182,185,187],"interacting":[29],"targets":[30],"offers":[31],"potential":[33],"for":[34,102,179],"higher":[35],"efficacy":[36,82],"and":[37,77,88,97,129,149,156,175],"may":[38],"limit":[39],"drawbacks":[40],"arising":[41],"use":[44],"single-target":[47],"or":[49,133],"combination":[51],"drugs.":[54,162],"More":[55],"high-quality":[56],"drug-target":[57,124,136,173],"interactions,":[58],"profiled":[59,161],"by":[60],"design":[64],"paradigm,":[65],"have":[66],"emerged":[67],"diverse":[69,121],"labs.":[70],"However,":[71],"rapid":[73],"production":[74],"at":[75],"scale":[76],"in":[78,92],"variety":[79],"challenges":[80],"data":[84,174],"usage.":[85],"A":[86],"creative":[87],"systematical":[89],"approach":[90,140,164],"demand":[93],"comprehensively":[95],"analyze":[96],"integrate":[98],"drug-":[99],"target":[100],"interactions":[101],"better":[103],"prediction.":[104],"In":[105],"project,":[107],"taking":[108],"diversity":[110],"into":[111],"consideration,":[112],"we":[113],"carried":[114],"out":[115],"gene":[117],"family-led,":[118],"meta-analysis,":[119],"investigated":[120],"properties":[122,153],"pharmacological":[125],"promiscuity":[126,159],"relies":[127],"on,":[128],"examined":[130],"consistency":[132],"integrity":[134],"data.":[137],"novel":[139],"can":[141,165],"facilitate":[142],"identification":[144],"cohesive":[146],"multi-target":[147],"combinations":[148],"revealed":[150],"interconnected":[152],"determining":[155],"rationalizing":[157],"be":[166],"further":[167],"expanded":[168],"coordinate":[170],"other":[171],"experimental":[172],"set":[176],"stage":[178],"analysis":[181],"mechanism":[184],"action":[186],"biological":[188],"therapies.":[189]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
