{"id":"https://openalex.org/W2774015426","doi":"https://doi.org/10.1109/bibm.2017.8218047","title":"Novel tumor biomarker based on isomiR expression profiles","display_name":"Novel tumor biomarker based on isomiR expression profiles","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2774015426","doi":"https://doi.org/10.1109/bibm.2017.8218047","mag":"2774015426"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8218047","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8218047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031520395","display_name":"Liang Chen","orcid":"https://orcid.org/0000-0001-6644-477X"},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Liang Chen","raw_affiliation_strings":["Faculty of Health Sciences, University of Macau, Macau, S.A.R., CHINA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, University of Macau, Macau, S.A.R., CHINA","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063000955","display_name":"Garry Wong","orcid":"https://orcid.org/0000-0003-4566-9958"},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Garry Wong","raw_affiliation_strings":["Faculty of Health Sciences, University of Macau, Macau, S.A.R., CHINA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, University of Macau, Macau, S.A.R., CHINA","institution_ids":["https://openalex.org/I204512498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0912,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47928372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"2328","last_page":"2329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5443366169929504},{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.521155595779419},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.4653201103210449},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.4447750747203827},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.42816174030303955},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40641582012176514},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2987324595451355},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.25729992985725403},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.240523099899292},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19064077734947205}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5443366169929504},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.521155595779419},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4653201103210449},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4447750747203827},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.42816174030303955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40641582012176514},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2987324595451355},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25729992985725403},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.240523099899292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19064077734947205}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8218047","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8218047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1680392829","https://openalex.org/W1994097106","https://openalex.org/W2006247279","https://openalex.org/W2015893546","https://openalex.org/W2042742026","https://openalex.org/W2043365501","https://openalex.org/W2045999258","https://openalex.org/W2074737068","https://openalex.org/W2077327925","https://openalex.org/W2117931291","https://openalex.org/W2130979840","https://openalex.org/W2142574304","https://openalex.org/W2168641639","https://openalex.org/W2172231567","https://openalex.org/W2558945705","https://openalex.org/W6637386731"],"related_works":["https://openalex.org/W1540936366","https://openalex.org/W2079625624","https://openalex.org/W2004254765","https://openalex.org/W2126407448","https://openalex.org/W2125691904","https://openalex.org/W200174347","https://openalex.org/W2048132363","https://openalex.org/W2953122964","https://openalex.org/W1971262350","https://openalex.org/W2507850257"],"abstract_inverted_index":{"With":[0],"the":[1,29,78,120,179],"development":[2,24],"of":[3,9,17,31,70,73,99,116,134,149,182],"deep":[4],"sequencing":[5],"technology,":[6],"isomiRs":[7],"(isoform":[8],"miRNA)":[10],"are":[11,34,37,56,106,136],"consistently":[12],"observed":[13,156],"in":[14,42,59,89],"a":[15,154],"variety":[16],"cell":[18,23],"types,":[19],"tissues,":[20,144],"and":[21,44,52,86,124,141],"different":[22,38,60,83,96,138],"stages.":[25],"miRNA":[26,32],"isoforms":[27],"as":[28,153],"products":[30],"genes,":[33],"variants":[35,68],"which":[36,145],"from":[39],"mature":[40],"miRNAs":[41],"length":[43],"position.":[45],"Recently,":[46],"many":[47],"studies":[48],"emphasized":[49],"on":[50],"isomiR":[51,71,79,100,107,110,135,150],"found":[53],"its":[54,74],"subtypes":[55],"differentially":[57],"expression":[58,75],"tumors.":[61],"In":[62],"this":[63],"work,":[64],"we":[65,93],"innovatively":[66],"apply":[67],"index":[69,128],"instead":[72],"to":[76,101,119,177],"discover":[77],"variant":[80,97,132,147],"signatures":[81],"that":[82],"between":[84,139],"tumor":[85,140,159,183],"normal":[87,143],"samples":[88],"TCGA":[90],"datasets.":[91],"Here":[92],"use":[94],"four":[95],"indexes":[98,133,148],"do":[102],"differential":[103],"analysis,":[104],"they":[105],"type's":[108],"counts,":[109],"average":[111,114],"length,":[112],"weighted":[113],"size":[115],"nucleotide":[117],"according":[118],"canonical":[121],"sequence":[122],"(WAZNVC)":[123],"information":[125],"entropy":[126],"based":[127],"(MIH).":[129],"Results":[130],"showed":[131],"significantly":[137],"adjacent":[142],"revealed":[146],"could":[151],"serve":[152],"good":[155],"object":[157],"for":[158],"biomarker":[160],"discovery.":[161],"Our":[162],"approach":[163],"employs":[164],"support":[165],"vector":[166],"machine":[167],"(SVM)":[168],"method":[169],"combining":[170],"leave":[171],"one":[172],"out":[173],"cross":[174],"validation":[175],"(LOOCV)":[176],"select":[178],"best":[180],"combination":[181],"markers.":[184]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}