{"id":"https://openalex.org/W2772294160","doi":"https://doi.org/10.1109/bibm.2017.8218039","title":"Quasi-palindrome effects on DNA sequence evolution","display_name":"Quasi-palindrome effects on DNA sequence evolution","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2772294160","doi":"https://doi.org/10.1109/bibm.2017.8218039","mag":"2772294160"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8218039","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8218039","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103284313","display_name":"Matt Spencer","orcid":"https://orcid.org/0000-0003-0273-3147"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matt Spencer","raw_affiliation_strings":["Informatics Institute, University of Missouri, Columbia, MO, USA"],"affiliations":[{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024965471","display_name":"Jacob Gotberg","orcid":null},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Gotberg","raw_affiliation_strings":["Research Computing, University of Missouri, Columbia, MO, USA"],"affiliations":[{"raw_affiliation_string":"Research Computing, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013031415","display_name":"Chi\u2010Ren Shyu","orcid":"https://orcid.org/0000-0001-9197-9522"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Ren Shyu","raw_affiliation_strings":["Informatics Institute, University of Missouri, Columbia, MO, USA"],"affiliations":[{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103284313"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":null,"apc_paid":null,"fwci":0.1063,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4987061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"2312","last_page":"2314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palindrome","display_name":"Palindrome","score":0.9277207255363464},{"id":"https://openalex.org/keywords/cruciform","display_name":"Cruciform","score":0.8059894442558289},{"id":"https://openalex.org/keywords/complementarity","display_name":"Complementarity (molecular biology)","score":0.7588002681732178},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5535755157470703},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.539461612701416},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.5113791823387146},{"id":"https://openalex.org/keywords/palindromic-sequence","display_name":"Palindromic sequence","score":0.4637302756309509},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.42249906063079834},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41725271940231323},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.41522789001464844},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.405910462141037},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18063154816627502},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09661129117012024},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.08765929937362671}],"concepts":[{"id":"https://openalex.org/C44667518","wikidata":"https://www.wikidata.org/wiki/Q12321","display_name":"Palindrome","level":4,"score":0.9277207255363464},{"id":"https://openalex.org/C2776086361","wikidata":"https://www.wikidata.org/wiki/Q5189819","display_name":"Cruciform","level":2,"score":0.8059894442558289},{"id":"https://openalex.org/C202269582","wikidata":"https://www.wikidata.org/wiki/Q2644277","display_name":"Complementarity (molecular biology)","level":2,"score":0.7588002681732178},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5535755157470703},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.539461612701416},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5113791823387146},{"id":"https://openalex.org/C76557","wikidata":"https://www.wikidata.org/wiki/Q369801","display_name":"Palindromic sequence","level":5,"score":0.4637302756309509},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.42249906063079834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41725271940231323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41522789001464844},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.405910462141037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18063154816627502},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09661129117012024},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.08765929937362671},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8218039","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8218039","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W967986046","https://openalex.org/W1970383168","https://openalex.org/W1989574513","https://openalex.org/W2005563268","https://openalex.org/W2009450264","https://openalex.org/W2015159527","https://openalex.org/W2020378172","https://openalex.org/W2033905999","https://openalex.org/W2063901213","https://openalex.org/W2108476495","https://openalex.org/W2132695846","https://openalex.org/W2774604274"],"related_works":["https://openalex.org/W2162181074","https://openalex.org/W1986616196","https://openalex.org/W2005909367","https://openalex.org/W4384664566","https://openalex.org/W2037433390","https://openalex.org/W2094943798","https://openalex.org/W2055277464","https://openalex.org/W2005563268","https://openalex.org/W2412607611","https://openalex.org/W1521119642"],"abstract_inverted_index":{"Quasi-palindromes":[0],"can":[1],"be":[2,123],"harmful":[3],"or":[4],"helpful,":[5],"but":[6],"most":[7,34,116],"of":[8,16,41,46,64,95,141],"this":[9,52,99],"functionality":[10],"is":[11],"attributed":[12],"to":[13,26,61,73,85,101,132],"the":[14,19,42,56,62,68,87,108,112,139,142],"formation":[15,29,63],"cruciforms.":[17],"Unfortunately,":[18],"general":[20,57],"properties":[21,59],"a":[22,47,127],"sequence":[23,58,143],"must":[24,122],"have":[25],"facilitate":[27],"cruciform":[28],"are":[30,144],"poorly":[31],"understood,":[32],"as":[33],"research":[35],"has":[36],"focused":[37],"on":[38],"case":[39],"studies":[40],"unusual":[43],"secondary":[44],"structures":[45],"few":[48],"specific":[49],"sequences.":[50],"In":[51],"work,":[53],"we":[54],"investigate":[55],"leading":[60],"cruciforms":[65,71],"by":[66],"exploiting":[67],"fact":[69],"that":[70,120,136],"lead":[72],"an":[74],"increased":[75],"mutation":[76,88],"rate.":[77],"We":[78,97],"use":[79],"evolutionary":[80],"divergences":[81],"in":[82,90],"protein-coding":[83],"sequences":[84],"calculate":[86],"rates":[89],"quasi-palindromes":[91,121],"with":[92,111,126],"different":[93,103],"degrees":[94],"self-complementarity.":[96],"perform":[98],"calculation":[100],"test":[102],"quasi-palindrome":[104],"properties,":[105],"then":[106],"compare":[107],"observed":[109],"patterns":[110],"expected":[113],"results.":[114],"The":[115],"promising":[117],"trials":[118],"indicate":[119],"10-30bp":[124],"long":[125],"self-complementarity":[128],"at":[129],"least":[130],"94%":[131],"form":[133],"cruciforms,":[134],"and":[135],"nucleotides":[137],"near":[138],"center":[140],"protected":[145],"from":[146],"mutation.":[147]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
