{"id":"https://openalex.org/W2773881678","doi":"https://doi.org/10.1109/bibm.2017.8218026","title":"Enabling precision medicine with CancerKB and KBCommons informatics framework","display_name":"Enabling precision medicine with CancerKB and KBCommons informatics framework","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2773881678","doi":"https://doi.org/10.1109/bibm.2017.8218026","mag":"2773881678"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8218026","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8218026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013248529","display_name":"Zhen Lyu","orcid":null},"institutions":[{"id":"https://openalex.org/I4777552","display_name":"University of Missouri System","ror":"https://ror.org/032va1j59","country_code":"US","type":"education","lineage":["https://openalex.org/I4777552"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhen Lyu","raw_affiliation_strings":["University of Missouri System, Columbia, MO, US"],"affiliations":[{"raw_affiliation_string":"University of Missouri System, Columbia, MO, US","institution_ids":["https://openalex.org/I4777552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103082007","display_name":"Shuai Zeng","orcid":"https://orcid.org/0000-0001-7632-427X"},"institutions":[{"id":"https://openalex.org/I4777552","display_name":"University of Missouri System","ror":"https://ror.org/032va1j59","country_code":"US","type":"education","lineage":["https://openalex.org/I4777552"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuai Zeng","raw_affiliation_strings":["University of Missouri System, Columbia, MO, US"],"affiliations":[{"raw_affiliation_string":"University of Missouri System, Columbia, MO, US","institution_ids":["https://openalex.org/I4777552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071079252","display_name":"Trupti Joshi","orcid":"https://orcid.org/0000-0001-8944-4924"},"institutions":[{"id":"https://openalex.org/I4777552","display_name":"University of Missouri System","ror":"https://ror.org/032va1j59","country_code":"US","type":"education","lineage":["https://openalex.org/I4777552"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trupti Joshi","raw_affiliation_strings":["University of Missouri System, Columbia, MO, US"],"affiliations":[{"raw_affiliation_string":"University of Missouri System, Columbia, MO, US","institution_ids":["https://openalex.org/I4777552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013248529"],"corresponding_institution_ids":["https://openalex.org/I4777552"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14552851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2281","last_page":"2281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9807000160217285,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/informatics","display_name":"Informatics","score":0.6261880397796631},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6153014302253723},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5471970438957214},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.4953364431858063},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.4876750707626343},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.4732264280319214},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"Cancer cell lines","score":0.45289769768714905},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.4526609182357788},{"id":"https://openalex.org/keywords/health-informatics-tools","display_name":"Health informatics tools","score":0.44727614521980286},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.42314955592155457},{"id":"https://openalex.org/keywords/data-visualization","display_name":"Data visualization","score":0.41462594270706177},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3893374800682068},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3887005150318146},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3509875535964966},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.32702720165252686},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3247676491737366},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17791613936424255},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1645096242427826},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.15547627210617065},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.14309677481651306},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10222095251083374}],"concepts":[{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.6261880397796631},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6153014302253723},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5471970438957214},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4953364431858063},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.4876750707626343},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.4732264280319214},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.45289769768714905},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.4526609182357788},{"id":"https://openalex.org/C167785021","wikidata":"https://www.wikidata.org/wiki/Q5691083","display_name":"Health informatics tools","level":3,"score":0.44727614521980286},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.42314955592155457},{"id":"https://openalex.org/C172367668","wikidata":"https://www.wikidata.org/wiki/Q6504956","display_name":"Data visualization","level":3,"score":0.41462594270706177},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3893374800682068},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3887005150318146},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3509875535964966},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.32702720165252686},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3247676491737366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17791613936424255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1645096242427826},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15547627210617065},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.14309677481651306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10222095251083374},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8218026","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8218026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W4399651953","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4403376686","https://openalex.org/W4298001029"],"abstract_inverted_index":{"Precision":[0],"Medicine":[1],"is":[2,47,67],"one":[3],"of":[4,15,45,99],"the":[5,28,41,100,230,238,269,277],"most":[6],"rapidly":[7],"evolving":[8],"areas":[9],"within":[10],"medicine,":[11],"which":[12,104,162],"allows":[13],"utilization":[14],"patient's":[16,222,270],"own":[17,271],"genomic":[18,34,223,272],"information":[19,136,225,274],"in":[20,40,191],"guiding":[21],"personalized":[22],"treatments":[23],"and":[24,35,43,62,77,80,85,133,142,149,171,177,187,196,213,226,247],"customized":[25],"therapy.":[26],"Applying":[27],"public":[29],"data":[30,53,64,115,126,152,216,242,251],"obtained":[31],"from":[32,153,252],"human":[33,128],"cancer":[36,139,169,201],"cell":[37,140,202],"line":[38],"studies":[39],"diagnosis":[42],"treatment":[44],"diseases":[46],"a":[48,97,109,264],"challenging":[49],"task":[50],"as":[51,175],"these":[52,182],"are":[54],"spread":[55],"across":[56],"different":[57],"repositories":[58],"with":[59,243,276],"diverse":[60],"formats":[61],"omics":[63],"types.":[65],"There":[66],"an":[68],"immediate":[69],"need":[70],"for":[71,102,112,127,137,167,281],"platforms":[72],"to":[73,83,218,221,236,262,266],"make":[74],"this":[75],"integration":[76],"analysis":[78,237],"seamless":[79],"readily":[81],"accessible":[82],"researchers":[84],"clinicians.":[86],"To":[87],"achieve":[88],"this,":[89],"we":[90],"have":[91,205],"implemented":[92],"Cancer":[93,155,192],"Cell":[94,193],"Line":[95,194],"KB,":[96],"branch":[98],"KBCommons":[101,121],"homoSapiens":[103],"focuses":[105],"on":[106],"automatically":[107],"establishing":[108],"web-based":[110],"resource":[111],"comprehensive":[113],"multi-omics":[114],"access":[116,220],"using":[117,184],"our":[118],"in-house":[119],"developed":[120,207,235],"framework.":[122],"It":[123],"currently":[124],"provides":[125],"genes":[129,173,199],"/":[130],"proteins,":[131],"miRNA,":[132],"publicly":[134],"available":[135],"1046":[138],"lines":[141],"drug":[143],"response":[144],"datasets.":[145],"Additionally,":[146],"gene":[147,227,240],"expression":[148,174,241],"de-identified":[150,249],"clinical":[151,215,250],"The":[154],"Genome":[156],"Atlas":[157],"has":[158],"also":[159,206,260],"been":[160],"added":[161],"includes":[163],"7706":[164],"patient":[165,214],"samples":[166],"20":[168],"types,":[170],"23368":[172],"FPKM":[176],"FeatureCounts.":[178],"Users":[179],"can":[180,254],"view":[181],"datasets":[183,280],"various":[185],"analytical":[186],"graphical":[188],"visualization":[189],"tools":[190],"KB":[195],"search":[197],"by":[198],"or":[200],"lines.":[203],"We":[204,259],"Principal":[208],"Component":[209],"Analysis":[210],"(PCA)":[211],"tool":[212,265],"browser":[217],"provide":[219],"tests":[224,273],"expression.":[228],"In":[229],"future,":[231],"heatmap":[232],"will":[233],"be":[234,255],"microarray":[239],"hierarchical":[244],"clustering":[245],"method":[246],"more":[248],"cBioportal":[253],"imported":[256],"through":[257],"WEB-API.":[258],"plan":[261],"implement":[263],"show":[267],"how":[268],"compares":[275],"population":[278],"based":[279],"that":[282],"disease":[283],"traits.":[284]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}