{"id":"https://openalex.org/W2771473935","doi":"https://doi.org/10.1109/bibm.2017.8217841","title":"Computational analysis to discover microRNA biomarkers in glioblastoma","display_name":"Computational analysis to discover microRNA biomarkers in glioblastoma","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2771473935","doi":"https://doi.org/10.1109/bibm.2017.8217841","mag":"2771473935"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8217841","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217841","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075049867","display_name":"Huawei Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huawei Jin","raw_affiliation_strings":["Department of Neurosurgery, Sun Yat-sen University Guangzhou, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Sun Yat-sen University Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114025829","display_name":"Zhenhua Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenhua Yu","raw_affiliation_strings":["Department of Neurosurgery, Sun Yat-sen University Guangzhou, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Sun Yat-sen University Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395105","display_name":"Xiaodan Wang","orcid":"https://orcid.org/0000-0001-9221-3510"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodan Wang","raw_affiliation_strings":["School of Nursing, Sun Yat-sen University, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"School of Nursing, Sun Yat-sen University, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038943054","display_name":"Weian Chen","orcid":"https://orcid.org/0000-0002-6582-1737"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weian Chen","raw_affiliation_strings":["Department of Nuclear Medicine, Sun Yat-sen University Guangzhou, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Sun Yat-sen University Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110474133","display_name":"Shaolei Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaolei Guo","raw_affiliation_strings":["Department of Neurosurgery, Sun Yat-sen University Guangzhou, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Sun Yat-sen University Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017519521","display_name":"Mohan Vamsi Kasukurthi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohan Vamsi Kasukurthi","raw_affiliation_strings":["School of Computing, University of South Alabama Mobile, Alabama, U.S.A"],"affiliations":[{"raw_affiliation_string":"School of Computing, University of South Alabama Mobile, Alabama, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066027793","display_name":"Glen M. Borchert","orcid":"https://orcid.org/0000-0002-6182-7154"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glen M. Borchert","raw_affiliation_strings":["College of Medicine, University of South Alabama Mobile, Alabama, U.S.A"],"affiliations":[{"raw_affiliation_string":"College of Medicine, University of South Alabama Mobile, Alabama, U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103191466","display_name":"Jingshan Huang","orcid":"https://orcid.org/0000-0003-2408-2883"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingshan Huang","raw_affiliation_strings":["School of Computing, University of South Alabama Mobile, Alabama, U.S.A"],"affiliations":[{"raw_affiliation_string":"School of Computing, University of South Alabama Mobile, Alabama, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5075049867"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.17757137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"4","issue":null,"first_page":"1270","last_page":"1271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.8132234811782837},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7816229462623596},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5865237712860107},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5445213317871094},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4595777690410614},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36744093894958496},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36508435010910034},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3335224986076355},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3294515609741211},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.30929380655288696},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10623487830162048}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.8132234811782837},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7816229462623596},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5865237712860107},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5445213317871094},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4595777690410614},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36744093894958496},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36508435010910034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3335224986076355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3294515609741211},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30929380655288696},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10623487830162048},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8217841","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217841","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335795","display_name":"Science and Technology Planning Project of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1448866238","https://openalex.org/W1560814177","https://openalex.org/W1977232125","https://openalex.org/W2096712415","https://openalex.org/W2151182769","https://openalex.org/W2158681922","https://openalex.org/W2208597264","https://openalex.org/W2381442930","https://openalex.org/W2574543389","https://openalex.org/W2624094894","https://openalex.org/W6633421435"],"related_works":["https://openalex.org/W1602805286","https://openalex.org/W4225917631","https://openalex.org/W2088686453","https://openalex.org/W4200635075","https://openalex.org/W4400475616","https://openalex.org/W2737319532","https://openalex.org/W2954466210","https://openalex.org/W4392896533","https://openalex.org/W2057742104","https://openalex.org/W4283692078"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"is":[3,19],"the":[4,47],"most":[5],"malignant":[6],"brain":[7],"tumor":[8],"with":[9],"rapid":[10],"relapse,":[11],"and":[12,58,80],"an":[13],"early":[14],"biomarker":[15],"identification":[16],"in":[17,36,42,85],"GBM":[18,43,71],"of":[20],"high":[21],"importance.":[22],"We":[23],"introduced":[24],"our":[25],"computational":[26],"methodologies":[27],"to":[28,64],"identify":[29],"serum":[30],"microRNAs":[31],"(miRNAs)":[32],"as":[33],"novel":[34],"biomarkers":[35,84],"GBM.":[37,86],"Differentially":[38],"expressed":[39],"miRNAs":[40,67],"(DEMs)":[41],"were":[44],"analyzed":[45],"from":[46],"Gene":[48],"Expression":[49],"Omnibus":[50],"(GEO)":[51],"repository;":[52],"we":[53],"then":[54],"combined":[55],"Venn":[56],"diagrams":[57],"OmniSearch,":[59],"a":[60],"semantic":[61],"search":[62],"tool,":[63],"filter":[65],"out":[66],"that":[68,77],"can":[69],"regulate":[70],"disease":[72],"process.":[73],"Our":[74],"results":[75],"indicated":[76],"miR-142-3p,":[78],"let-7c,":[79],"miR-140-5p":[81],"are":[82],"candidate":[83]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}