{"id":"https://openalex.org/W2775687305","doi":"https://doi.org/10.1109/bibm.2017.8217814","title":"A semantic knowledge-base approach to drug-drug interaction discovery","display_name":"A semantic knowledge-base approach to drug-drug interaction discovery","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2775687305","doi":"https://doi.org/10.1109/bibm.2017.8217814","mag":"2775687305"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8217814","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217814","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018002605","display_name":"Ignacio J. Tripodi","orcid":"https://orcid.org/0000-0003-3066-4273"},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ignacio Tripodi","raw_affiliation_strings":["Computer Science, University of Colorado, Boulder"],"affiliations":[{"raw_affiliation_string":"Computer Science, University of Colorado, Boulder","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062221063","display_name":"Kevin Bretonnel Cohen","orcid":"https://orcid.org/0000-0003-1749-8290"},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin B. Cohen","raw_affiliation_strings":["Computational Bioscience, University of Colorado, Denver"],"affiliations":[{"raw_affiliation_string":"Computational Bioscience, University of Colorado, Denver","institution_ids":["https://openalex.org/I188538660","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041860080","display_name":"Lawrence Hunter","orcid":"https://orcid.org/0000-0003-1455-3370"},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence E. Hunter","raw_affiliation_strings":["Computational Bioscience, University of Colorado, Denver"],"affiliations":[{"raw_affiliation_string":"Computational Bioscience, University of Colorado, Denver","institution_ids":["https://openalex.org/I188538660","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018002605"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":0.4542,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67620883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"116","issue":null,"first_page":"1123","last_page":"1126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7207050919532776},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5763139724731445},{"id":"https://openalex.org/keywords/knowledge-base","display_name":"Knowledge base","score":0.5687059164047241},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5646328330039978},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5485230684280396},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.4885355234146118},{"id":"https://openalex.org/keywords/drug-drug-interaction","display_name":"Drug-drug interaction","score":0.43973278999328613},{"id":"https://openalex.org/keywords/semantic-similarity","display_name":"Semantic similarity","score":0.4396296441555023},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35474693775177},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34455522894859314},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.2534504532814026},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2531636357307434},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.13614332675933838},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12709537148475647},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11512130498886108}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7207050919532776},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5763139724731445},{"id":"https://openalex.org/C4554734","wikidata":"https://www.wikidata.org/wiki/Q593744","display_name":"Knowledge base","level":2,"score":0.5687059164047241},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5646328330039978},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5485230684280396},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4885355234146118},{"id":"https://openalex.org/C2910466267","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug-drug interaction","level":3,"score":0.43973278999328613},{"id":"https://openalex.org/C130318100","wikidata":"https://www.wikidata.org/wiki/Q2268914","display_name":"Semantic similarity","level":2,"score":0.4396296441555023},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35474693775177},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34455522894859314},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2534504532814026},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2531636357307434},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13614332675933838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12709537148475647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11512130498886108},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8217814","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217814","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1990480666","https://openalex.org/W1995726799","https://openalex.org/W2018518196","https://openalex.org/W2061866519","https://openalex.org/W2094344445","https://openalex.org/W2107450474","https://openalex.org/W2108798001","https://openalex.org/W2114054568","https://openalex.org/W2118027190","https://openalex.org/W2147714160","https://openalex.org/W2148130205","https://openalex.org/W2170526892","https://openalex.org/W2197199201","https://openalex.org/W2200364087","https://openalex.org/W2248340309","https://openalex.org/W2589489260","https://openalex.org/W2599646426","https://openalex.org/W3025091095","https://openalex.org/W6674234289","https://openalex.org/W6676150899","https://openalex.org/W6687671185","https://openalex.org/W6691510337","https://openalex.org/W6777619479"],"related_works":["https://openalex.org/W2480711475","https://openalex.org/W2388928357","https://openalex.org/W2061997414","https://openalex.org/W1587522533","https://openalex.org/W2153190755","https://openalex.org/W2121182182","https://openalex.org/W1996411829","https://openalex.org/W3017600601","https://openalex.org/W135095951","https://openalex.org/W2044905153"],"abstract_inverted_index":{"We":[0],"propose":[1],"a":[2,16,25,73],"novel,":[3],"semantic-reasoning-based":[4],"approach":[5,30],"to":[6,34,84],"look":[7],"for":[8],"potentially":[9],"adverse":[10,108],"drug-drug":[11,86,94],"interactions":[12,95,103],"(DDIs)":[13],"by":[14],"using":[15],"knowledge-base":[17],"of":[18],"biomedical":[19],"public":[20],"ontologies":[21],"and":[22,46,49,64],"datasets":[23],"in":[24,60,78,97],"semantic":[26,62],"graph":[27],"representation.":[28],"This":[29],"makes":[31],"it":[32],"possible":[33],"find":[35],"previously":[36],"unknown":[37],"relations":[38],"between":[39,67],"different":[40],"biological":[41,47],"entities":[42],"like":[43],"drugs,":[44],"proteins":[45],"processes,":[48],"perform":[50],"inferences":[51],"on":[52],"those":[53],"relations.":[54],"Finding":[55],"nodes":[56,69],"that":[57,104],"represent":[58],"drugs":[59],"this":[61],"graph,":[63],"intersecting":[65,71],"pathways":[66,90],"these":[68],"(e.g.":[70],"at":[72],"metabolic":[74],"pathway":[75],"step":[76],"described":[77],"Reactome":[79],"[1]":[80],"data),":[81],"can":[82],"yield":[83],"novel":[85],"interactions.":[87],"The":[88],"resulting":[89],"not":[91],"only":[92],"describe":[93],"reflected":[96],"the":[98],"literature,":[99],"but":[100],"also":[101],"unstudied":[102],"could":[105],"elucidate":[106],"reported":[107],"effects.":[109]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
