{"id":"https://openalex.org/W2774668147","doi":"https://doi.org/10.1109/bibm.2017.8217756","title":"Comprehensive analysis of pulmonary adenocarcinoma in situ (AIS) revealed new insights into lung cancer progression","display_name":"Comprehensive analysis of pulmonary adenocarcinoma in situ (AIS) revealed new insights into lung cancer progression","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2774668147","doi":"https://doi.org/10.1109/bibm.2017.8217756","mag":"2774668147"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8217756","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217756","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100380747","display_name":"Dan Li","orcid":"https://orcid.org/0000-0002-5586-4055"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dan Li","raw_affiliation_strings":["MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A"],"affiliations":[{"raw_affiliation_string":"MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102746299","display_name":"William Yang","orcid":"https://orcid.org/0000-0002-0514-325X"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Yang","raw_affiliation_strings":["Dept. of Computer Science, School of Computer Science, Pittsburgh, PA, U.S.A","Yale School of Medicine, Yale University, New Haven, CT, U.S.A"],"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science, School of Computer Science, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Yale School of Medicine, Yale University, New Haven, CT, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376975","display_name":"Yifan Zhang","orcid":"https://orcid.org/0009-0001-2662-1126"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yifan Zhang","raw_affiliation_strings":["MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A"],"affiliations":[{"raw_affiliation_string":"MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037410384","display_name":"Jack Yang","orcid":"https://orcid.org/0000-0003-3589-6807"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Y. Yang","raw_affiliation_strings":["MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A"],"affiliations":[{"raw_affiliation_string":"MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068886380","display_name":"Weida Tong","orcid":"https://orcid.org/0000-0003-3488-6148"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weida Tong","raw_affiliation_strings":["Division of Bioinformatics and Biostatistics, United States Food and Drug Administration (FDA), Arkansas, U.S.A"],"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, United States Food and Drug Administration (FDA), Arkansas, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007914848","display_name":"Renchu Guan","orcid":"https://orcid.org/0000-0002-7162-7826"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I102401767","display_name":"University of Arkansas at Little Rock","ror":"https://ror.org/04fttyv97","country_code":"US","type":"education","lineage":["https://openalex.org/I102401767"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Renchu Guan","raw_affiliation_strings":["College of Computer Sci. & Tech., Jilin University, Changchun, Jilin, CHN","MidSouth Bioinformatics Center & Joint Bioinformatics Ph.D. Program of UALR-UAMS, The University of Arkansas, Little Rock, Arkansas, USA"],"affiliations":[{"raw_affiliation_string":"College of Computer Sci. & Tech., Jilin University, Changchun, Jilin, CHN","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"MidSouth Bioinformatics Center & Joint Bioinformatics Ph.D. Program of UALR-UAMS, The University of Arkansas, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I102401767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103566591","display_name":"Mary Qu Yang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Qu Yang","raw_affiliation_strings":["MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A"],"affiliations":[{"raw_affiliation_string":"MidSouth Bioinformatics Center, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100380747"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.18188984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"9","issue":null,"first_page":"792","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.6621931791305542},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.63411945104599},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6321251392364502},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4999685287475586},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.47407546639442444},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.42761027812957764},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3958553671836853},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2967444062232971},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.28007781505584717},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17545276880264282}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6621931791305542},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.63411945104599},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6321251392364502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4999685287475586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47407546639442444},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42761027812957764},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3958553671836853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2967444062232971},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.28007781505584717},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17545276880264282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8217756","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217756","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W44815768","https://openalex.org/W273955616","https://openalex.org/W1555951822","https://openalex.org/W2000000541","https://openalex.org/W2011657487","https://openalex.org/W2029919331","https://openalex.org/W2032347891","https://openalex.org/W2041992600","https://openalex.org/W2045883724","https://openalex.org/W2081130360","https://openalex.org/W2106678197","https://openalex.org/W2116302527","https://openalex.org/W2117098110","https://openalex.org/W2117688129","https://openalex.org/W2124231374","https://openalex.org/W2128619556","https://openalex.org/W2130116522","https://openalex.org/W2131271579","https://openalex.org/W2134526812","https://openalex.org/W2136922672","https://openalex.org/W2141458291","https://openalex.org/W2149390239","https://openalex.org/W2158217645","https://openalex.org/W2164153952","https://openalex.org/W2167114526","https://openalex.org/W2169456326","https://openalex.org/W2174181728","https://openalex.org/W2420947713","https://openalex.org/W2423124209","https://openalex.org/W2529308621","https://openalex.org/W2601712260","https://openalex.org/W2625043156","https://openalex.org/W6601785968","https://openalex.org/W6678609824"],"related_works":["https://openalex.org/W2064573700","https://openalex.org/W2376385980","https://openalex.org/W2967366602","https://openalex.org/W1496498748","https://openalex.org/W2129774558","https://openalex.org/W1997032381","https://openalex.org/W1979593122","https://openalex.org/W2287922696","https://openalex.org/W2190548886","https://openalex.org/W2783341158"],"abstract_inverted_index":{"Pulmonary":[0],"adenocarcinoma":[1,11,45,58],"in":[2,156,185],"situ":[3],"(AIS)":[4],"is":[5,46,72],"an":[6,186],"intermediate":[7],"subtype":[8],"of":[9,24,57,76,106,119,137,163,221,253],"lung":[10,44,91,168,194,254],"that":[12,102,153,161,212,235],"exhibits":[13],"non-invasive":[14],"growth":[15],"patterns,":[16],"but":[17],"can":[18,27],"develop":[19],"into":[20],"invasive.":[21],"Almost":[22],"100%":[23],"AIS":[25,128,157,222,238],"patients":[26],"be":[28,70],"cured":[29],"with":[30,42,98,172,223],"complete":[31],"resection.":[32],"In":[33,50,79],"contrast,":[34],"the":[35,77,104,115,164,229,233,250],"five-year":[36],"survival":[37],"rate":[38],"for":[39,190,237],"those":[40],"diagnosed":[41],"invasive":[43,90,112,226,241],"only":[47],"about":[48],"4%.":[49],"order":[51],"to":[52,69,94,216,240,249,259],"get":[53],"a":[54,73,134],"better":[55],"understanding":[56],"and":[59,65,89,111,122,129,148,196,209,225],"identify":[60,95],"marks":[61],"indicating":[62,191],"its":[63],"evaluation":[64,75],"progression,":[66],"what":[67],"needs":[68],"done":[71],"genome-wide":[74],"disease.":[78],"this":[80],"study,":[81],"we":[82,132,244],"used":[83],"RNA-seq":[84],"data":[85,188],"from":[86,109],"normal,":[87],"AIS,":[88,107],"cancer":[92,169,195,217],"samples":[93],"gene":[96,100,230],"module":[97],"differential":[99,116],"expressions":[101],"represents":[103],"properties":[105],"distinct":[108],"normal":[110,197,224],"tumor.":[113],"Utilizing":[114],"expression":[117],"patterns":[118],"protein-coding":[120,143,165],"genes":[121,140,166,171,180,200],"long":[123],"non-coding":[124],"RNAs":[125],"(lncRNAs)":[126],"between":[127],"other":[130],"conditions,":[131],"obtained":[133],"small":[135],"group":[136],"72":[138],"AIS-specific":[139,179],"consisting":[141],"41":[142],"genes,":[144],"5":[145],"annotated":[146],"lncRNAs,":[147],"26":[149],"novel":[150],"lncRNA":[151],"transcripts":[152],"expressed":[154],"specifically":[155],"samples.":[158],"We":[159],"consider":[160],"twelve":[162],"are":[167,201,213],"driver":[170,174],"located":[173],"somatic":[175],"mutations.":[176],"Moreover,":[177],"these":[178],"show":[181],"capabilities":[182],"(98%":[183],"accuracy":[184],"independent":[187],"set)":[189],"early":[192,251],"stage":[193],"situations.":[198],"These":[199],"determined":[202],"based":[203],"on":[204],"cell-adhesion":[205],"functioning,":[206],"including":[207],"angiogenesis":[208],"fibronectin,":[210],"etc.,":[211],"highly":[214],"related":[215],"development.":[218],"The":[219],"comparison":[220],"tumor":[227],"provides":[228],"list":[231],"revealing":[232],"mechanisms":[234],"accounts":[236],"progression":[239],"cancer.":[242],"Furthermore":[243],"identified":[245],"important":[246],"signatures":[247],"contributing":[248],"diagnosis":[252],"cancer,":[255],"providing":[256],"auxiliary":[257],"studies":[258],"our":[260],"ongoing":[261],"precision":[262],"medicine":[263],"research":[264],"(http://americancse.org/events/csce2017/keynotes_lectures/yang_talk).":[265]},"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
