{"id":"https://openalex.org/W2774694797","doi":"https://doi.org/10.1109/bibm.2017.8217639","title":"Mathematical model for pancreatic cancer progression using non-constant gene mutation rate","display_name":"Mathematical model for pancreatic cancer progression using non-constant gene mutation rate","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2774694797","doi":"https://doi.org/10.1109/bibm.2017.8217639","mag":"2774694797"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8217639","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073146939","display_name":"Shuhao Sun","orcid":"https://orcid.org/0000-0002-5418-1236"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shuhao Sun","raw_affiliation_strings":["School of Mathematical Science, Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical Science, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024274776","display_name":"Fima C. Klebaner","orcid":"https://orcid.org/0000-0001-8044-9761"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fima Klebaner","raw_affiliation_strings":["School of Mathematical Science, Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical Science, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039097797","display_name":"Tianhai Tian","orcid":"https://orcid.org/0000-0001-6191-0209"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tianhai Tian","raw_affiliation_strings":["School of Mathematical Science, Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical Science, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"138","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.7412266135215759},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6947166323661804},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.67030930519104},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6645098924636841},{"id":"https://openalex.org/keywords/constant","display_name":"Constant (computer programming)","score":0.5650116205215454},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.41731417179107666},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3312462866306305},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32012659311294556},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3003159761428833},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27930065989494324},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2674042582511902},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22895285487174988},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21277368068695068}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7412266135215759},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6947166323661804},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.67030930519104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6645098924636841},{"id":"https://openalex.org/C2777027219","wikidata":"https://www.wikidata.org/wiki/Q1284190","display_name":"Constant (computer programming)","level":2,"score":0.5650116205215454},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.41731417179107666},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3312462866306305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32012659311294556},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3003159761428833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27930065989494324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2674042582511902},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22895285487174988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21277368068695068},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8217639","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1509191294","https://openalex.org/W1586880664","https://openalex.org/W1885155229","https://openalex.org/W1964154017","https://openalex.org/W1976414440","https://openalex.org/W1981508636","https://openalex.org/W1992928961","https://openalex.org/W2011912935","https://openalex.org/W2015631955","https://openalex.org/W2023568503","https://openalex.org/W2034509811","https://openalex.org/W2040827479","https://openalex.org/W2042813882","https://openalex.org/W2050023459","https://openalex.org/W2062249523","https://openalex.org/W2066254965","https://openalex.org/W2070547493","https://openalex.org/W2073531001","https://openalex.org/W2086535578","https://openalex.org/W2099583365","https://openalex.org/W2120627772","https://openalex.org/W2132528779","https://openalex.org/W2138155367","https://openalex.org/W2163235555","https://openalex.org/W2167263582","https://openalex.org/W2169895148","https://openalex.org/W2179429273","https://openalex.org/W2235523093","https://openalex.org/W2937931695","https://openalex.org/W4210955308","https://openalex.org/W4238448376","https://openalex.org/W4240237951","https://openalex.org/W6630399264","https://openalex.org/W6680539993","https://openalex.org/W6761207861"],"related_works":["https://openalex.org/W2146397496","https://openalex.org/W2167177400","https://openalex.org/W2076383445","https://openalex.org/W2592888218","https://openalex.org/W2136281516","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W4231831369","https://openalex.org/W2097774084","https://openalex.org/W2606677068"],"abstract_inverted_index":{"Cancer":[0],"of":[1,31,85,112],"the":[2,49],"pancreas":[3],"is":[4,45,53,56],"a":[5,71,96],"highly":[6],"lethal":[7],"disease":[8],"and":[9,17,29,63,78,95,104,115],"has":[10],"an":[11],"extremely":[12],"poor":[13],"prognosis.":[14],"Mathematical":[15],"modelling":[16],"computer":[18],"simulations":[19],"have":[20,116],"been":[21],"proposed":[22,102],"as":[23],"important":[24,37,82],"tool":[25],"to":[26],"predictor":[27],"initiation":[28],"progression":[30],"cancer":[32,39,86,113],"diseases,":[33],"which":[34,55],"are":[35],"very":[36],"in":[38],"study.":[40],"Among":[41],"these":[42],"studies,":[43],"it":[44],"widely":[46],"assumed":[47],"that":[48],"gene":[50,93],"mutation":[51,76,94,99],"rate":[52,77],"unchanged,":[54],"not":[57],"realistic":[58,90],"based":[59],"on":[60],"recently":[61],"biological":[62,83],"medical":[64],"studies.":[65],"In":[66],"this":[67],"work,":[68],"we":[69],"present":[70],"new":[72],"approach":[73],"using":[74],"non-constant":[75],"hence":[79],"reveal":[80],"several":[81],"parameters":[84],"progression.":[87],"Under":[88],"more":[89,97],"assumptions":[91],"regarding":[92],"reasonable":[98],"rate,":[100],"our":[101],"model":[103],"calculated":[105],"results":[106],"may":[107],"provide":[108],"insights":[109],"into":[110],"dynamics":[111],"metastasis":[114],"clinic":[117],"implications.":[118]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}