{"id":"https://openalex.org/W2772471823","doi":"https://doi.org/10.1109/bibm.2017.8217633","title":"A new statistical model for genome-scale MicroRNA target prediction","display_name":"A new statistical model for genome-scale MicroRNA target prediction","publication_year":2017,"publication_date":"2017-11-01","ids":{"openalex":"https://openalex.org/W2772471823","doi":"https://doi.org/10.1109/bibm.2017.8217633","mag":"2772471823"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2017.8217633","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217633","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029927409","display_name":"Zeynep Hakguder","orcid":null},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeynep Hakguder","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Nebraska, Lincoln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Nebraska, Lincoln","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012190254","display_name":"Chunxiao Liao","orcid":"https://orcid.org/0000-0003-0344-7134"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunxiao Liao","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Nebraska, Lincoln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Nebraska, Lincoln","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012418559","display_name":"Jiang Shu","orcid":"https://orcid.org/0000-0001-7677-721X"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiang Shu","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Nebraska, Lincoln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Nebraska, Lincoln","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029528457","display_name":"Juan Cui","orcid":"https://orcid.org/0000-0001-6581-6850"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Cui","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Nebraska, Lincoln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Nebraska, Lincoln","institution_ids":["https://openalex.org/I114395901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114395901"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"101","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7180801630020142},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6799329519271851},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4680715799331665},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4439700245857239},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43758973479270935},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4283483028411865},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3343351483345032},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.33419954776763916},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2679837942123413}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7180801630020142},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6799329519271851},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4680715799331665},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4439700245857239},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43758973479270935},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4283483028411865},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3343351483345032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33419954776763916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2679837942123413},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2017.8217633","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2017.8217633","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1972989638","https://openalex.org/W2016106370","https://openalex.org/W2026570544","https://openalex.org/W2037141750","https://openalex.org/W2038622868","https://openalex.org/W2041509376","https://openalex.org/W2048724765","https://openalex.org/W2051663161","https://openalex.org/W2059806955","https://openalex.org/W2074915514","https://openalex.org/W2078849828","https://openalex.org/W2083381199","https://openalex.org/W2088833308","https://openalex.org/W2093404711","https://openalex.org/W2104806799","https://openalex.org/W2120456037","https://openalex.org/W2123250471","https://openalex.org/W2128219894","https://openalex.org/W2150395782","https://openalex.org/W2161229134","https://openalex.org/W2168173728","https://openalex.org/W2180388440","https://openalex.org/W2784380838"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2050308539","https://openalex.org/W3151405604","https://openalex.org/W4241694095","https://openalex.org/W2330252996","https://openalex.org/W2793648706","https://openalex.org/W3043187607","https://openalex.org/W2565797512"],"abstract_inverted_index":{"MicroRNAs":[0],"regulate":[1],"virtually":[2],"the":[3,23,34,70,91,111,132,140,167,171],"whole":[4],"gene":[5],"network":[6],"in":[7,14,39,147,158,181],"human":[8,148,169],"body":[9],"and":[10,17,43,63,74,82,126,131,162,188],"have":[11,50,135],"been":[12,51,136],"implicated":[13],"most":[15],"physiological":[16],"pathological":[18],"conditions":[19],"including":[20],"cancers.":[21],"Understanding":[22],"precise":[24],"mechanisms":[25],"of":[26,37,121,128,143,183],"microRNA-mRNA":[27],"interaction":[28],"is":[29],"fundamentally":[30],"important":[31,35],"to":[32,124,138,196],"elucidate":[33],"roles":[36],"miRNA":[38,54],"regulating":[40],"various":[41],"cellular":[42],"disease":[44],"developmental":[45],"stages.":[46],"Numerous":[47],"computational":[48,104],"methods":[49],"developed":[52],"for":[53,84,106],"target":[55,86,108],"prediction,":[56],"mostly":[57],"focusing":[58],"on":[59,66,153,166,192],"static":[60],"binding":[61,77,133,145,193],"prediction":[62,109,142,187],"highly":[64],"dependent":[65],"sequence-pairing":[67],"interactions.":[68],"However,":[69],"interplay":[71],"between":[72],"competing":[73],"cooperative":[75],"microRNA-target":[76],"makes":[78],"it":[79],"exceptionally":[80],"complex":[81],"challenging":[83],"reliable":[85],"identification,":[87],"which":[88],"has":[89],"hindered":[90],"existing":[92],"tools":[93,180],"from":[94],"practical":[95],"use.":[96],"In":[97],"this":[98],"study,":[99],"we":[100],"present":[101],"a":[102,163],"new":[103,144],"method":[105],"microRNA":[107],"using":[110],"Dirichlet":[112],"Process":[113],"Gaussian":[114],"Mixture":[115],"Model":[116],"(DPGMM).":[117],"A":[118],"comprehensive":[119],"collection":[120],"features":[122],"related":[123],"sequence":[125],"structure":[127],"microRNAs,":[129],"mRNAs,":[130],"sites":[134,146,194],"assessed":[137],"optimize":[139],"statistical":[141],"transcriptome.":[149],"Through":[150],"multiple":[151],"evaluations":[152],"recently-discovered":[154],"miRNA-mRNA":[155],"interactions":[156],"reported":[157],"large-scale":[159],"sequencing":[160],"analyses":[161],"screening":[164],"test":[165],"entire":[168],"transcripts,":[170],"results":[172],"show":[173],"that":[174],"our":[175],"model":[176],"outperformed":[177],"several":[178],"state-of-the-art":[179],"terms":[182],"reduced":[184],"false":[185],"positive":[186],"promising":[189],"predictive":[190],"power":[191],"specific":[195],"transcript":[197],"isoforms.":[198]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}