{"id":"https://openalex.org/W2571907309","doi":"https://doi.org/10.1109/bibm.2016.7822806","title":"Developing a robust colorectal cancer (CRC) risk predictive model with the big genetic and environment related CRC data","display_name":"Developing a robust colorectal cancer (CRC) risk predictive model with the big genetic and environment related CRC data","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2571907309","doi":"https://doi.org/10.1109/bibm.2016.7822806","mag":"2571907309"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2016.7822806","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822806","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029889544","display_name":"Chunqiu Zheng","orcid":"https://orcid.org/0000-0001-5172-1834"},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunqiu Zheng","raw_affiliation_strings":["College of Computer and Information Science, Southwest University, Chongqing, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer and Information Science, Southwest University, Chongqing, P. R., China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381465","display_name":"Lei Xing","orcid":"https://orcid.org/0000-0002-4913-9818"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xing","raw_affiliation_strings":["School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, P. R., China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345588","display_name":"Tian Li","orcid":"https://orcid.org/0000-0003-2850-4537"},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Li","raw_affiliation_strings":["College of Computer and Information Science, Southwest University, Chongqing, P. R., China","College of Mathematics and Statistics, Southwest University, Chongqing, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer and Information Science, Southwest University, Chongqing, P. R., China","institution_ids":["https://openalex.org/I142108993"]},{"raw_affiliation_string":"College of Mathematics and Statistics, Southwest University, Chongqing, P. R., China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518530","display_name":"Tingting Li","orcid":"https://orcid.org/0000-0002-6920-7099"},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Li","raw_affiliation_strings":["College of Computer and Information Science, Southwest University, Chongqing, P. R., China","College of Mathematics and Statistics, Southwest University, Chongqing, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer and Information Science, Southwest University, Chongqing, P. R., China","institution_ids":["https://openalex.org/I142108993"]},{"raw_affiliation_string":"College of Mathematics and Statistics, Southwest University, Chongqing, P. R., China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101932031","display_name":"Huan Yang","orcid":"https://orcid.org/0000-0003-4570-2228"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Yang","raw_affiliation_strings":["Department of Environment Health, Third Military Medical University,, Chongqing, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environment Health, Third Military Medical University,, Chongqing, P. R., China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100661099","display_name":"Jia Cao","orcid":"https://orcid.org/0000-0001-7209-2993"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Cao","raw_affiliation_strings":["Department of Environment Health, Third Military Medical University,, Chongqing, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environment Health, Third Military Medical University,, Chongqing, P. R., China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077852542","display_name":"Badong Chen","orcid":"https://orcid.org/0000-0003-1710-3818"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Badong Chen","raw_affiliation_strings":["School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, P. R., China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046745579","display_name":"Ziyuan Zhou","orcid":"https://orcid.org/0000-0002-7689-9601"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyuan Zhou","raw_affiliation_strings":["Department of Environment Health, Third Military Medical University,, Chongqing, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environment Health, Third Military Medical University,, Chongqing, P. R., China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100350625","display_name":"Le Zhang","orcid":"https://orcid.org/0000-0002-3708-1727"},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Zhang","raw_affiliation_strings":["College of Mathematics and Statistics, Southwest University, Chongqing, P. R., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Mathematics and Statistics, Southwest University, Chongqing, P. R., China","institution_ids":["https://openalex.org/I142108993"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15380311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1885","last_page":"1893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11233","display_name":"Advanced Adaptive Filtering Techniques","score":0.9273999929428101,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11233","display_name":"Advanced Adaptive Filtering Techniques","score":0.9273999929428101,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10688","display_name":"Image and Signal Denoising Methods","score":0.9007999897003174,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.7893353700637817},{"id":"https://openalex.org/keywords/predictive-power","display_name":"Predictive power","score":0.6830260753631592},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.5827846527099609},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.5126373171806335},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.46627524495124817},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4600934386253357},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4456143379211426},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4412262439727783},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3416198492050171},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3295215368270874},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3249305784702301},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.20973211526870728}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7893353700637817},{"id":"https://openalex.org/C2778136018","wikidata":"https://www.wikidata.org/wiki/Q10350689","display_name":"Predictive power","level":2,"score":0.6830260753631592},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5827846527099609},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.5126373171806335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46627524495124817},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4600934386253357},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4456143379211426},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4412262439727783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3416198492050171},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3295215368270874},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3249305784702301},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.20973211526870728},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2016.7822806","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822806","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W104105986","https://openalex.org/W1491720019","https://openalex.org/W1565176583","https://openalex.org/W1680392829","https://openalex.org/W1819447595","https://openalex.org/W1876246457","https://openalex.org/W1953138840","https://openalex.org/W1970999566","https://openalex.org/W1975900269","https://openalex.org/W1984127772","https://openalex.org/W1988370082","https://openalex.org/W1995150421","https://openalex.org/W1995875735","https://openalex.org/W2005405421","https://openalex.org/W2011197824","https://openalex.org/W2012656458","https://openalex.org/W2013974060","https://openalex.org/W2022894179","https://openalex.org/W2025816890","https://openalex.org/W2027197817","https://openalex.org/W2029909328","https://openalex.org/W2032088224","https://openalex.org/W2035596487","https://openalex.org/W2037735355","https://openalex.org/W2042433654","https://openalex.org/W2043192290","https://openalex.org/W2044689389","https://openalex.org/W2052392879","https://openalex.org/W2054609442","https://openalex.org/W2054979538","https://openalex.org/W2070845530","https://openalex.org/W2071820974","https://openalex.org/W2074718000","https://openalex.org/W2076220518","https://openalex.org/W2089454337","https://openalex.org/W2089468765","https://openalex.org/W2092683145","https://openalex.org/W2095692554","https://openalex.org/W2100185175","https://openalex.org/W2100769096","https://openalex.org/W2106787323","https://openalex.org/W2107014760","https://openalex.org/W2118391523","https://openalex.org/W2119982549","https://openalex.org/W2120321361","https://openalex.org/W2121239890","https://openalex.org/W2128728535","https://openalex.org/W2131878646","https://openalex.org/W2135722220","https://openalex.org/W2141130185","https://openalex.org/W2142927241","https://openalex.org/W2150305259","https://openalex.org/W2153111162","https://openalex.org/W2153290280","https://openalex.org/W2154572047","https://openalex.org/W2162530578","https://openalex.org/W2164078599","https://openalex.org/W2164272712","https://openalex.org/W2167932108","https://openalex.org/W2185701945","https://openalex.org/W2313106333","https://openalex.org/W2481926318","https://openalex.org/W2497286450","https://openalex.org/W3023058184","https://openalex.org/W3024853581","https://openalex.org/W3147238174","https://openalex.org/W3149245626","https://openalex.org/W4211001330","https://openalex.org/W4211199921","https://openalex.org/W4246756383","https://openalex.org/W4256619014","https://openalex.org/W4292928781","https://openalex.org/W4372135308","https://openalex.org/W6637386731","https://openalex.org/W6640123090","https://openalex.org/W6644246945","https://openalex.org/W6680139798","https://openalex.org/W6684045843","https://openalex.org/W6686447416","https://openalex.org/W6759431858","https://openalex.org/W6776535907","https://openalex.org/W6987337520"],"related_works":["https://openalex.org/W4247566972","https://openalex.org/W2960264696","https://openalex.org/W3090563135","https://openalex.org/W2497432351","https://openalex.org/W4206777497","https://openalex.org/W2910064364","https://openalex.org/W4255224757","https://openalex.org/W2499527417","https://openalex.org/W1819546497","https://openalex.org/W3133294580"],"abstract_inverted_index":{"Currently,":[0],"colorectal":[1],"cancer":[2],"(CRC)":[3],"already":[4],"becomes":[5],"one":[6],"of":[7,16,72,127],"the":[8,14,24,31,36,50,79,92,101,111,114,120,125,133,154,158,163],"most":[9],"common":[10],"cancers":[11],"worldwide.":[12],"Though":[13],"prognosis":[15],"CRC":[17,37,46,68,80,94,112,128],"patients":[18,81],"is":[19,39],"dramatically":[20],"improved":[21],"due":[22],"to":[23,54,88,109],"new":[25],"advanced":[26],"treatments":[27],"and":[28,57,75,82,90,104,162],"medical":[29],"improvements,":[30],"5-year":[32],"survival":[33],"rate":[34],"for":[35,78],"patient":[38],"still":[40],"low.":[41],"Thus,":[42],"we":[43,151],"hypothesize":[44],"that":[45,85,99],"may":[47],"result":[48],"from":[49],"complicated":[51],"reasons":[52],"related":[53,164],"both":[55],"genetic":[56,73,103],"environmental":[58,76,105],"factors.":[59],"For":[60],"this":[61,63],"reason,":[62],"study":[64],"collects":[65],"such":[66],"big":[67,134],"data":[69],"with":[70],"information":[71],"variations":[74],"exposure":[77],"cancer-free":[83],"controls":[84],"are":[86,107],"employed":[87],"train":[89],"test":[91],"predictive":[93,148],"model.":[95],"Our":[96],"results":[97],"demonstrate":[98],"(1)":[100],"explored":[102],"biomarkers":[106],"validated":[108],"cause":[110],"by":[113,132],"manually":[115],"reviewed":[116],"experimental":[117],"evidences,":[118],"(2)":[119],"model":[121],"can":[122,156],"efficiently":[123],"predict":[124],"risk":[126],"after":[129],"parameter":[130],"optimization":[131],"CRC-related":[135],"data,":[136],"(3)":[137],"our":[138],"innovated":[139],"generalized":[140],"kernel":[141],"recursive":[142],"maximum":[143],"correntropy(GKRMC)":[144],"algorithm":[145],"has":[146],"high":[147],"power.":[149],"Finally,":[150],"discuss":[152],"why":[153],"GKRMC":[155],"outperform":[157],"classical":[159],"regression":[160],"algorithms":[161],"future":[165],"study.":[166]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}