{"id":"https://openalex.org/W2573063337","doi":"https://doi.org/10.1109/bibm.2016.7822729","title":"Triptolide regulates immune response network against systemic lupus erythematosus","display_name":"Triptolide regulates immune response network against systemic lupus erythematosus","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2573063337","doi":"https://doi.org/10.1109/bibm.2016.7822729","mag":"2573063337"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2016.7822729","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822729","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078573286","display_name":"Guang Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang Zheng","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, Lanzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, Lanzhou, P.R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332271","display_name":"Zhibin Wang","orcid":"https://orcid.org/0000-0001-7441-7536"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhibin Wang","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, Lanzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, Lanzhou, P.R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002040719","display_name":"Chengqiang Li","orcid":"https://orcid.org/0000-0002-8549-2416"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengqiang Li","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, Lanzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, Lanzhou, P.R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101535857","display_name":"Hongtao Guo","orcid":"https://orcid.org/0000-0003-0659-5829"},"institutions":[{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongtao Guo","raw_affiliation_strings":["The first affiliated hospital of Henan University of TCM, Zhengzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The first affiliated hospital of Henan University of TCM, Zhengzhou, P.R. China","institution_ids":["https://openalex.org/I4210144860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610290","display_name":"Jihua Wang","orcid":"https://orcid.org/0000-0002-9299-3438"},"institutions":[{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihua Wang","raw_affiliation_strings":["The first affiliated hospital of Henan University of TCM, Zhengzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The first affiliated hospital of Henan University of TCM, Zhengzhou, P.R. China","institution_ids":["https://openalex.org/I4210144860"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086580108","display_name":"Xiaojuan He","orcid":"https://orcid.org/0000-0003-0553-0919"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan He","raw_affiliation_strings":["Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"163","issue":null,"first_page":"1409","last_page":"1414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9764000177383423,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triptolide","display_name":"Triptolide","score":0.9937373399734497},{"id":"https://openalex.org/keywords/tripterygium-wilfordii","display_name":"Tripterygium wilfordii","score":0.8351726531982422},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.7276474237442017},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5396729707717896},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"Systemic lupus erythematosus","score":0.4901905655860901},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4873271882534027},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.44373226165771484},{"id":"https://openalex.org/keywords/lupus-erythematosus","display_name":"Lupus erythematosus","score":0.43506407737731934},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"Immune dysregulation","score":0.4337315261363983},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.36471307277679443},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.33412861824035645},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.29811230301856995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25976550579071045},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10828477144241333}],"concepts":[{"id":"https://openalex.org/C2781164371","wikidata":"https://www.wikidata.org/wiki/Q906351","display_name":"Triptolide","level":3,"score":0.9937373399734497},{"id":"https://openalex.org/C2780695664","wikidata":"https://www.wikidata.org/wiki/Q1424919","display_name":"Tripterygium wilfordii","level":3,"score":0.8351726531982422},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7276474237442017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5396729707717896},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4901905655860901},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4873271882534027},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.44373226165771484},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.43506407737731934},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.4337315261363983},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36471307277679443},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.33412861824035645},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.29811230301856995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25976550579071045},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10828477144241333},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/bibm.2016.7822729","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822729","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/303397","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/303397","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u4f1a\u8bae\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/308070","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/308070","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u4f1a\u8bae\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/397001","is_oa":false,"landing_page_url":"https://ieeexplore.ieee.org/document/7822729/","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference article (CA)"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1551080404","https://openalex.org/W1924919590","https://openalex.org/W1965917470","https://openalex.org/W1999722941","https://openalex.org/W2056816828","https://openalex.org/W2062273607","https://openalex.org/W2081276994","https://openalex.org/W2096173332","https://openalex.org/W2096541451","https://openalex.org/W2100097277","https://openalex.org/W2110256992","https://openalex.org/W2123066708","https://openalex.org/W2129678711","https://openalex.org/W2152274187","https://openalex.org/W2159430424","https://openalex.org/W2159675211","https://openalex.org/W2161271012","https://openalex.org/W2164137907","https://openalex.org/W2274356554","https://openalex.org/W2294516783","https://openalex.org/W2333707811","https://openalex.org/W2461509596","https://openalex.org/W2473972959","https://openalex.org/W4313335875","https://openalex.org/W6674494894","https://openalex.org/W6694531898"],"related_works":["https://openalex.org/W1990990881","https://openalex.org/W1591876936","https://openalex.org/W2393996197","https://openalex.org/W2363351871","https://openalex.org/W2325575762","https://openalex.org/W2349560056","https://openalex.org/W2359851146","https://openalex.org/W2368598214","https://openalex.org/W2217874721","https://openalex.org/W2391889807"],"abstract_inverted_index":{"Traditional":[0],"Chinese":[1],"medicine":[2],"has":[3],"been":[4],"using":[5],"Tripterygium":[6],"wilfordii":[7],"Hook":[8],"f.":[9],"(TWHF)":[10],"against":[11,50,98],"systemic":[12],"lupus":[13],"erythematosus":[14],"(SLE)":[15],"over":[16],"200":[17],"years.":[18],"Triptolide":[19],"is":[20,43],"an":[21,72],"active":[22],"compound":[23],"of":[24,48,69,103,113,128,134],"TWHF":[25],"with":[26,100],"therapeutic":[27,96],"effects":[28],"for":[29],"auto-immune":[30],"disease":[31],"SLE.":[32],"However,":[33],"till":[34],"now,":[35],"few":[36],"associated":[37],"studies":[38],"were":[39,139],"reported":[40],"and":[41,85,117,136],"little":[42],"known":[44],"about":[45],"the":[46,54,63,67,94],"mechanism":[47],"triptolide":[49],"SLE":[51,79,99,119],"which":[52],"blocks":[53],"new":[55],"drug":[56],"discovery.":[57],"In":[58],"this":[59,129],"study,":[60],"focused":[61],"on":[62],"proteins":[64,116],"participated":[65],"in":[66],"process":[68,83],"immune":[70,104],"respond,":[71],"integrated":[73],"bioinformatics":[74],"analysis":[75],"covering":[76],"targeted":[77,115],"proteins,":[78],"OMIM":[80,120],"genes,":[81],"biological":[82],"enrichment,":[84],"protein-protein":[86],"interactions":[87],"(PPI)":[88],"was":[89,106],"deployed.":[90],"As":[91],"a":[92,110],"result,":[93],"candidate":[95],"network":[97,112,130],"negative":[101],"regulation":[102],"response":[105],"proposed.":[107],"It":[108],"contains":[109],"PPI":[111],"7":[114,118],"genes":[121],"further":[122],"regulated":[123],"by":[124],"triptolide.":[125],"Primary":[126],"validation":[127],"indicating":[131],"that":[132],"processes":[133,138],"apoptosis":[135],"pro-inflammatory":[137],"involved.":[140]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}