{"id":"https://openalex.org/W2576112076","doi":"https://doi.org/10.1109/bibm.2016.7822619","title":"Predicting disease-microbe association by random walking on the heterogeneous network","display_name":"Predicting disease-microbe association by random walking on the heterogeneous network","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2576112076","doi":"https://doi.org/10.1109/bibm.2016.7822619","mag":"2576112076"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2016.7822619","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101496385","display_name":"Xianjun Shen","orcid":"https://orcid.org/0000-0001-5714-8848"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianjun Shen","raw_affiliation_strings":["School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394279","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0003-2708-8674"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003550654","display_name":"Xingpeng Jiang","orcid":"https://orcid.org/0000-0002-8848-9300"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingpeng Jiang","raw_affiliation_strings":["School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101569679","display_name":"Xiaohua Hu","orcid":"https://orcid.org/0000-0002-4777-3022"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohua Hu","raw_affiliation_strings":["School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667898","display_name":"Tingting He","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting He","raw_affiliation_strings":["School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002718976","display_name":"Jincai Yang","orcid":"https://orcid.org/0000-0002-4446-5809"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jincai Yang","raw_affiliation_strings":["School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40963666"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":null,"first_page":"771","last_page":"774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.784753680229187},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5157273411750793},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.49796485900878906},{"id":"https://openalex.org/keywords/heterogeneous-network","display_name":"Heterogeneous network","score":0.4847704768180847},{"id":"https://openalex.org/keywords/prioritization","display_name":"Prioritization","score":0.47557273507118225},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.437516987323761},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4247472882270813},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3562736511230469},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28295618295669556},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2665995955467224},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.08482930064201355},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.08429023623466492},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07431855797767639}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.784753680229187},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5157273411750793},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.49796485900878906},{"id":"https://openalex.org/C158207573","wikidata":"https://www.wikidata.org/wiki/Q5747224","display_name":"Heterogeneous network","level":4,"score":0.4847704768180847},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.47557273507118225},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.437516987323761},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4247472882270813},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3562736511230469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28295618295669556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2665995955467224},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08482930064201355},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.08429023623466492},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07431855797767639},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C108037233","wikidata":"https://www.wikidata.org/wiki/Q11375","display_name":"Wireless network","level":3,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2016.7822619","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5199999809265137}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1869281583","https://openalex.org/W1977431865","https://openalex.org/W1979328481","https://openalex.org/W2011312755","https://openalex.org/W2012606594","https://openalex.org/W2025155127","https://openalex.org/W2025513962","https://openalex.org/W2041073071","https://openalex.org/W2048184127","https://openalex.org/W2050591900","https://openalex.org/W2056782822","https://openalex.org/W2058710717","https://openalex.org/W2067806364","https://openalex.org/W2072417345","https://openalex.org/W2091840905","https://openalex.org/W2100582962","https://openalex.org/W2110621364","https://openalex.org/W2112631688","https://openalex.org/W2119220491","https://openalex.org/W2121983115","https://openalex.org/W2135989088","https://openalex.org/W2140452573","https://openalex.org/W2150968312","https://openalex.org/W2154660883","https://openalex.org/W2156522249","https://openalex.org/W2239108612","https://openalex.org/W2322763599","https://openalex.org/W2431459199","https://openalex.org/W2742484040"],"related_works":["https://openalex.org/W2506292322","https://openalex.org/W4283209547","https://openalex.org/W4367627632","https://openalex.org/W2184980933","https://openalex.org/W2165268799","https://openalex.org/W1927327903","https://openalex.org/W653452717","https://openalex.org/W2382997850","https://openalex.org/W1544665982","https://openalex.org/W2022479666"],"abstract_inverted_index":{"The":[0],"microbiota":[1],"living":[2],"in":[3,12],"the":[4,18,40,44,68,72,84,91,97,101,111,115,121,157,168,171],"human":[5],"body":[6],"plays":[7],"a":[8,53,79,175],"very":[9,49],"important":[10],"role":[11],"our":[13],"health":[14],"and":[15,31,46,87,113,130,153,155,184],"disease,":[16],"so":[17],"identification":[19],"of":[20,35,58,170],"microbes":[21,47,60,159],"associated":[22,160],"with":[23,161],"diseases":[24,45],"will":[25,173],"contribute":[26],"to":[27,32,61,100,109,123],"improving":[28],"medical":[29],"care":[30],"better":[33],"understanding":[34],"microbe":[36,88,131,137],"functions,":[37],"interactions.":[38],"However,":[39],"known":[41],"associations":[42,172],"between":[43,128],"are":[48],"less.":[50],"We":[51,119,165],"proposed":[52],"new":[54],"method":[55,112],"for":[56,179],"prioritization":[57],"candidate":[59,116],"predict":[62],"disease-microbe":[63,92],"relationships":[64],"that":[65,132,167],"based":[66],"on":[67,71],"random":[69,98],"walking":[70],"heterogeneous":[73,80,102],"network.":[74],"Here,":[75],"we":[76,105,144],"first":[77],"constructed":[78],"network":[81,86,89,138,141],"by":[82,136],"connecting":[83],"disease":[85,129,140,180],"using":[90],"relationship":[93],"information,":[94],"then":[95],"extended":[96],"walk":[99],"network,":[103],"finally":[104],"used":[106,120],"leave-one-out":[107],"cross-validation":[108],"evaluate":[110],"ranked":[114],"disease-causing":[117],"microbes.":[118],"algorithm":[122],"disclose":[124],"some":[125],"potential":[126,158],"association":[127],"cannot":[133],"be":[134,174],"found":[135],"or":[139],"alone.":[142],"Furthermore,":[143],"studied":[145],"three":[146],"representative":[147],"diseases,":[148,163],"Type":[149],"2":[150],"diabetes,":[151],"Asthma":[152],"Psoriasis,":[154],"presented":[156],"these":[162],"respectively.":[164],"confirmed":[166],"discovery":[169],"good":[176],"clinical":[177],"solution":[178],"mechanism":[181],"understanding,":[182],"diagnosis":[183],"therapy.":[185]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}