{"id":"https://openalex.org/W2578490714","doi":"https://doi.org/10.1109/bibm.2016.7822559","title":"Imaging-genetic data mapping for clinical outcome prediction via supervised conditional Gaussian graphical model","display_name":"Imaging-genetic data mapping for clinical outcome prediction via supervised conditional Gaussian graphical model","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2578490714","doi":"https://doi.org/10.1109/bibm.2016.7822559","mag":"2578490714"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2016.7822559","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822559","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102586120","display_name":"Xinliang Zhu","orcid":"https://orcid.org/0000-0002-4544-2078"},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xinliang Zhu","raw_affiliation_strings":["Department of Computer Science and Engineering, The University of Texas, Arlington, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, The University of Texas, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075245264","display_name":"Jiawen Yao","orcid":"https://orcid.org/0000-0001-7429-2964"},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiawen Yao","raw_affiliation_strings":["Department of Computer Science and Engineering, The University of Texas, Arlington, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, The University of Texas, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009964025","display_name":"Guanghua Xiao","orcid":"https://orcid.org/0000-0001-9387-9883"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanghua Xiao","raw_affiliation_strings":["Department of Clinical Science, The University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Science, The University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100661771","display_name":"Yang Xie","orcid":"https://orcid.org/0000-0001-9456-1762"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Xie","raw_affiliation_strings":["Department of Clinical Science, The University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Science, The University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010423488","display_name":"Jaime Rodriguez\u2010Canales","orcid":"https://orcid.org/0000-0002-0885-2377"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime Rodriguez-Canales","raw_affiliation_strings":["Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043477787","display_name":"Edwin R. Parra","orcid":"https://orcid.org/0000-0001-9068-1636"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin R. Parra","raw_affiliation_strings":["Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009105122","display_name":"Carmen Behrens","orcid":"https://orcid.org/0000-0003-1905-8061"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Behrens","raw_affiliation_strings":["Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028085268","display_name":"Ignacio I. Wistuba","orcid":"https://orcid.org/0000-0003-3365-6340"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignacio I. Wistuba","raw_affiliation_strings":["Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068865316","display_name":"Junzhou Huang","orcid":"https://orcid.org/0000-0002-9548-1227"},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junzhou Huang","raw_affiliation_strings":["Department of Computer Science and Engineering, The University of Texas, Arlington, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, The University of Texas, Arlington, TX, USA","institution_ids":["https://openalex.org/I189196454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5102586120"],"corresponding_institution_ids":["https://openalex.org/I189196454"],"apc_list":null,"apc_paid":null,"fwci":1.0041,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.79027872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"455","last_page":"459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphical-model","display_name":"Graphical model","score":0.6990361213684082},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6013941764831543},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5282332897186279},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.4991488456726074},{"id":"https://openalex.org/keywords/projection","display_name":"Projection (relational algebra)","score":0.48669344186782837},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4629913568496704},{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.42385923862457275},{"id":"https://openalex.org/keywords/data-modeling","display_name":"Data modeling","score":0.41383546590805054},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38683515787124634},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.375088632106781},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.25136011838912964}],"concepts":[{"id":"https://openalex.org/C155846161","wikidata":"https://www.wikidata.org/wiki/Q1143367","display_name":"Graphical model","level":2,"score":0.6990361213684082},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6013941764831543},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5282332897186279},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.4991488456726074},{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.48669344186782837},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4629913568496704},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.42385923862457275},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.41383546590805054},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38683515787124634},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.375088632106781},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.25136011838912964},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2016.7822559","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822559","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W297461772","https://openalex.org/W1526543462","https://openalex.org/W1539811621","https://openalex.org/W1580788756","https://openalex.org/W1899679829","https://openalex.org/W1989539998","https://openalex.org/W2001334414","https://openalex.org/W2012339972","https://openalex.org/W2019176983","https://openalex.org/W2019605179","https://openalex.org/W2035592710","https://openalex.org/W2042592512","https://openalex.org/W2049123275","https://openalex.org/W2053404654","https://openalex.org/W2089838152","https://openalex.org/W2107554012","https://openalex.org/W2110243528","https://openalex.org/W2125782079","https://openalex.org/W2149199519","https://openalex.org/W2150461375","https://openalex.org/W2163149604","https://openalex.org/W2272823987","https://openalex.org/W2358113125","https://openalex.org/W2422375349","https://openalex.org/W2524308422","https://openalex.org/W2525036370","https://openalex.org/W2526712471","https://openalex.org/W2963020974","https://openalex.org/W3099521927","https://openalex.org/W3147894994","https://openalex.org/W6610472804","https://openalex.org/W6631555775","https://openalex.org/W6634508654","https://openalex.org/W6640015824","https://openalex.org/W6661276618","https://openalex.org/W6678941407","https://openalex.org/W6692092902"],"related_works":["https://openalex.org/W2109986081","https://openalex.org/W2417308975","https://openalex.org/W4297589944","https://openalex.org/W4368755698","https://openalex.org/W2964129930","https://openalex.org/W4388627352","https://openalex.org/W1808888439","https://openalex.org/W4240337634","https://openalex.org/W27988576","https://openalex.org/W2279165687"],"abstract_inverted_index":{"Imaging-genetic":[0],"data":[1,41,121],"mapping":[2,28,137],"is":[3,108],"important":[4],"for":[5],"clinical":[6],"outcome":[7],"prediction":[8],"like":[9,102],"survival":[10,26,44,138],"analysis.":[11],"In":[12],"this":[13],"paper,":[14],"we":[15,57],"propose":[16,69],"a":[17,54,70,81,123],"supervised":[18,89,124],"conditional":[19,92],"Gaussian":[20,93],"graphical":[21,94],"model":[22,45,90,95],"(SuperCGGM)":[23],"to":[24,61,75,83,98,111],"uncover":[25],"associated":[27,139],"between":[29,87],"pathological":[30],"images":[31],"and":[32,68,141],"genetic":[33],"data.":[34,51],"The":[35,126],"proposed":[36],"method":[37,107],"integrates":[38],"heterogeneous":[39,119],"modal":[40,120],"into":[42],"the":[43,50,62,85,88,131],"by":[46],"weighted":[47],"projection":[48],"within":[49],"To":[52],"obtain":[53],"sparse":[55],"solution,":[56],"employ":[58],"l-1":[59],"regularization":[60],"partial":[63],"log":[64],"likelihood":[65],"loss":[66],"function":[67],"cyclic":[71],"coordinate":[72],"ascent":[73],"algorithm":[74],"solve":[76],"it.":[77],"It":[78],"also":[79,129],"gives":[80],"way":[82],"bridge":[84],"gap":[86],"with":[91],"(CGGM).":[96],"Compared":[97],"nine":[99],"state-of-the-art":[100],"methods":[101],"SuperPCA,":[103],"CGGM,":[104],"etc.,":[105],"our":[106],"superior":[109],"due":[110],"its":[112],"ability":[113],"of":[114,134],"integrating":[115],"diverse":[116],"information":[117],"from":[118],"in":[122,136],"way.":[125],"extensive":[127],"experiments":[128],"show":[130],"strong":[132],"power":[133],"SuperCGGM":[135],"image":[140],"gene":[142],"expression":[143],"signatures.":[144]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}