{"id":"https://openalex.org/W2576575324","doi":"https://doi.org/10.1109/bibm.2016.7822537","title":"A algorithm for identifying disease genes by incorporating the subcellular localization information into the protein-protein interaction networks","display_name":"A algorithm for identifying disease genes by incorporating the subcellular localization information into the protein-protein interaction networks","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2576575324","doi":"https://doi.org/10.1109/bibm.2016.7822537","mag":"2576575324"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2016.7822537","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822537","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078015522","display_name":"Xiwei Tang","orcid":"https://orcid.org/0000-0002-7719-3213"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]},{"id":"https://openalex.org/I916048824","display_name":"Hunan First Normal University","ror":"https://ror.org/00s9d1a36","country_code":"CN","type":"education","lineage":["https://openalex.org/I916048824"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiwei Tang","raw_affiliation_strings":["College of Computer, National University of Defense Technology, Changsha, China","College of Computing and Informatics, Drexel University, Philadelphia, PA, USA","School of Information Science and Engineering, Hunan First Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer, National University of Defense Technology, Changsha, China","institution_ids":["https://openalex.org/I170215575"]},{"raw_affiliation_string":"College of Computing and Informatics, Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of Information Science and Engineering, Hunan First Normal University, Changsha, China","institution_ids":["https://openalex.org/I916048824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101569679","display_name":"Xiaohua Hu","orcid":"https://orcid.org/0000-0002-4777-3022"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohua Hu","raw_affiliation_strings":["College of Computing and Informatics, Drexel University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computing and Informatics, Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061870286","display_name":"Xuejun Yang","orcid":"https://orcid.org/0000-0002-8595-545X"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuejun Yang","raw_affiliation_strings":["College of Computing and Informatics, Drexel University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computing and Informatics, Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101242430","display_name":"Yuan Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I916048824","display_name":"Hunan First Normal University","ror":"https://ror.org/00s9d1a36","country_code":"CN","type":"education","lineage":["https://openalex.org/I916048824"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Sun","raw_affiliation_strings":["School of Information Science and Engineering, Hunan First Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Hunan First Normal University, Changsha, China","institution_ids":["https://openalex.org/I916048824"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"308","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6679576635360718},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6077693104743958},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.48666912317276},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.44340649247169495},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.42811712622642517},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41294023394584656},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40793973207473755},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3936060070991516},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.35285547375679016},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3236445486545563},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16619578003883362},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09736907482147217},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.06796851754188538}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6679576635360718},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6077693104743958},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48666912317276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44340649247169495},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.42811712622642517},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41294023394584656},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40793973207473755},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3936060070991516},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35285547375679016},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3236445486545563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16619578003883362},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09736907482147217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06796851754188538},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2016.7822537","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822537","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1605637875","https://openalex.org/W1838763289","https://openalex.org/W1976768790","https://openalex.org/W1999808266","https://openalex.org/W2010000580","https://openalex.org/W2040411864","https://openalex.org/W2042822099","https://openalex.org/W2054108659","https://openalex.org/W2084294502","https://openalex.org/W2100628741","https://openalex.org/W2104261859","https://openalex.org/W2108181223","https://openalex.org/W2109555487","https://openalex.org/W2115746733","https://openalex.org/W2118607021","https://openalex.org/W2119220491","https://openalex.org/W2121507105","https://openalex.org/W2124649657","https://openalex.org/W2132056568","https://openalex.org/W2154455818","https://openalex.org/W2163485494","https://openalex.org/W2201354711","https://openalex.org/W2517354921","https://openalex.org/W6682494755"],"related_works":["https://openalex.org/W2898732673","https://openalex.org/W2410053581","https://openalex.org/W2383658677","https://openalex.org/W3123203398","https://openalex.org/W2961085424","https://openalex.org/W3107784576","https://openalex.org/W4286629047","https://openalex.org/W623104033","https://openalex.org/W1972473893","https://openalex.org/W2466435674"],"abstract_inverted_index":{"Disease":[0],"gene":[1],"identification":[2],"is":[3,101],"a":[4,14,97,137],"key":[5],"step":[6],"to":[7,36,60,64,103],"understand":[8],"the":[9,43,50,54,65,69,75,82,91,108,116,122,162],"cellular":[10],"mechanisms":[11],"associated":[12],"with":[13,18,74,90],"specific":[15],"disease.":[16],"Compared":[17],"biological":[19,85],"experiments,":[20],"computational":[21,32],"predictions":[22],"of":[23,56,84,128,136,147],"disease":[24,105,129,157],"genes":[25,39,131],"are":[26,34,79,112,132,142,153],"cheaper":[27],"and":[28,176],"more":[29],"effortless.":[30],"Many":[31],"methods":[33,58,78,173],"used":[35],"detect":[37],"causal":[38],"for":[40],"diseases":[41],"on":[42,144],"protein-protein":[44],"interaction":[45],"(PPI)":[46],"networks":[47,111],"generated":[48],"by":[49,114],"high-throughput":[51],"technology.":[52],"However,":[53],"accuracy":[55],"these":[57],"need":[59],"be":[61],"improved":[62],"due":[63],"false":[66],"interactions":[67],"in":[68,134],"PPI":[70,92,110,124],"data.":[71],"To":[72],"deal":[73],"challenge,":[76],"other":[77,171],"proposed":[80],"via":[81],"integration":[83],"information":[86,120],"from":[87,161],"different":[88],"sources":[89],"networks.":[93,125],"In":[94],"this":[95],"work,":[96],"new":[98],"algorithm":[99],"AIDG":[100,169],"developed":[102],"predict":[104],"genes.":[106,158],"First,":[107],"weighted":[109],"built":[113],"incorporating":[115],"protein":[117],"subcellular":[118],"localization":[119],"into":[121],"human":[123],"Next,":[126],"all":[127],"candidate":[130],"scored":[133],"terms":[135],"iteration":[138],"function.":[139],"Finally,":[140],"they":[141],"ranked":[143],"descending":[145],"order":[146],"their":[148],"scores.":[149],"The":[150,159],"top":[151],"candidates":[152],"considered":[154],"as":[155],"potential":[156],"results":[160],"leave-one-out":[163],"crossing":[164],"validation":[165],"(LOOCV)":[166],"show":[167],"that":[168],"outperforms":[170],"similar":[172],"like":[174],"DADA":[175],"ToppNet.":[177]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}