{"id":"https://openalex.org/W2575788895","doi":"https://doi.org/10.1109/bibm.2016.7822488","title":"Predicting microRNA-environmental factor interactions based on bi-random walk and multi-label learning","display_name":"Predicting microRNA-environmental factor interactions based on bi-random walk and multi-label learning","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2575788895","doi":"https://doi.org/10.1109/bibm.2016.7822488","mag":"2575788895"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2016.7822488","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822488","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041285376","display_name":"Wei Lan","orcid":"https://orcid.org/0000-0001-5839-7504"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lan","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438360","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0003-1516-0480"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719013","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-0188-1394"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065367210","display_name":"Chengqian Lu","orcid":"https://orcid.org/0000-0001-9201-6912"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengqian Lu","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091157395","display_name":"Fang\u2010Xiang Wu","orcid":"https://orcid.org/0000-0002-4593-9332"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fang-Xiang Wu","raw_affiliation_strings":["Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101465265","display_name":"Yi Pan","orcid":"https://orcid.org/0000-0002-2766-3096"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Pan","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, USA","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":"27","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.6943504810333252},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.690472424030304},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6209918260574341},{"id":"https://openalex.org/keywords/random-walk","display_name":"Random walk","score":0.5966809988021851},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5897966623306274},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5294297337532043},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4632033109664917},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.4610883593559265},{"id":"https://openalex.org/keywords/factor","display_name":"Factor (programming language)","score":0.45778408646583557},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.43645691871643066},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4234638512134552},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.42127999663352966},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.42092499136924744},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.378306120634079},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33206480741500854},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24388962984085083},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22979384660720825},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18947362899780273},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.13091635704040527},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.12494906783103943},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11172047257423401},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.08650627732276917}],"concepts":[{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.6943504810333252},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.690472424030304},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6209918260574341},{"id":"https://openalex.org/C121194460","wikidata":"https://www.wikidata.org/wiki/Q856741","display_name":"Random walk","level":2,"score":0.5966809988021851},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5897966623306274},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5294297337532043},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4632033109664917},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.4610883593559265},{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.45778408646583557},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.43645691871643066},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4234638512134552},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.42127999663352966},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.42092499136924744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.378306120634079},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33206480741500854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24388962984085083},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22979384660720825},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18947362899780273},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.13091635704040527},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12494906783103943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11172047257423401},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.08650627732276917},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2016.7822488","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822488","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1815337875","https://openalex.org/W1914708428","https://openalex.org/W1967547933","https://openalex.org/W1975441976","https://openalex.org/W1977181995","https://openalex.org/W1987219048","https://openalex.org/W1987455407","https://openalex.org/W1989788262","https://openalex.org/W2006247279","https://openalex.org/W2007879260","https://openalex.org/W2008289103","https://openalex.org/W2044073319","https://openalex.org/W2047967134","https://openalex.org/W2052684427","https://openalex.org/W2056593219","https://openalex.org/W2060906515","https://openalex.org/W2062533676","https://openalex.org/W2077327925","https://openalex.org/W2081150348","https://openalex.org/W2087007556","https://openalex.org/W2090247362","https://openalex.org/W2106029302","https://openalex.org/W2114315281","https://openalex.org/W2117472344","https://openalex.org/W2122915854","https://openalex.org/W2123060905","https://openalex.org/W2128463395","https://openalex.org/W2131835644","https://openalex.org/W2136037673","https://openalex.org/W2140291328","https://openalex.org/W2146256775","https://openalex.org/W2146292498","https://openalex.org/W2154722286","https://openalex.org/W2170493345","https://openalex.org/W2189673550","https://openalex.org/W2258129851","https://openalex.org/W2260355669","https://openalex.org/W2324728706","https://openalex.org/W2340802671","https://openalex.org/W2346950316","https://openalex.org/W2417990257","https://openalex.org/W2463737032","https://openalex.org/W2531500048"],"related_works":["https://openalex.org/W3193043704","https://openalex.org/W4386259002","https://openalex.org/W1546989560","https://openalex.org/W1597743604","https://openalex.org/W3171520305","https://openalex.org/W2038723108","https://openalex.org/W3135126032","https://openalex.org/W1924178503","https://openalex.org/W4308716060","https://openalex.org/W4280648719"],"abstract_inverted_index":{"Increasing":[0],"evidences":[1],"have":[2],"shown":[3,170],"that":[4,171],"microRNAs":[5],"(miRNAs)":[6],"play":[7],"important":[8],"roles":[9],"in":[10,24,157],"many":[11],"diseases.":[12],"The":[13,78,160],"environmental":[14,76,94,104,122],"factors":[15],"(EFs)":[16],"can":[17],"regulate":[18],"the":[19,39,126,128,147,153,158],"expression":[20],"level":[21],"of":[22,41,83,93,101,119,149,165],"miRNAs":[23,74,102,120],"human":[25],"tissues.":[26],"Therefore,":[27],"identifying":[28],"potential":[29,139],"miRNA-environmental":[30,140,178],"factor":[31,95,141,179],"interactions":[32,72],"is":[33,173],"helpful":[34],"not":[35],"only":[36],"for":[37,45],"understanding":[38],"pathogenesis":[40],"diseases,":[42],"but":[43],"also":[44],"disease":[46],"diagnosis,":[47],"prognosis":[48],"and":[49,67,75,80,85,90,103,121,131],"treatment.":[50],"In":[51,107,125,143],"this":[52],"paper,":[53],"we":[54,109,151],"propose":[55],"a":[56],"computational":[57],"framework,":[58],"MEI-BRWMLL":[59,161,172],"(MiRNA-EF":[60],"Interaction":[61],"prediction":[62],"based":[63],"on":[64],"Bi-Random":[65],"walk":[66,130],"Multi-Label":[68],"Learning),":[69],"to":[70,98,115,137,145,175],"identify":[71,138,176],"between":[73],"factors.":[77],"sequence":[79],"topology":[81,91],"information":[82,92,118],"miRNA":[84],"structure,":[86],"anatomical":[87],"therapeutic":[88],"chemical":[89],"are":[96,135],"employed":[97],"measure":[99],"similarity":[100,111],"factors,":[105,123],"respectively.":[106,124],"addition,":[108],"use":[110],"network":[112],"fusion":[113],"method":[114,134],"integrate":[116],"biological":[117],"last,":[127],"bi-random":[129],"multi-label":[132],"learning":[133],"utilized":[136],"interactions.":[142,180],"order":[144],"evaluate":[146],"performance":[148],"MEI-BRWMLL,":[150],"implement":[152],"ten-fold":[154],"cross":[155],"validation":[156],"experiment.":[159],"achieves":[162],"an":[163],"AUC":[164],"0.8208.":[166],"It":[167],"has":[168],"been":[169],"able":[174],"known":[177]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}