{"id":"https://openalex.org/W2576351525","doi":"https://doi.org/10.1109/bibm.2016.7822484","title":"Clinical application of precision medicine: Zhongshan Hospital strategy","display_name":"Clinical application of precision medicine: Zhongshan Hospital strategy","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2576351525","doi":"https://doi.org/10.1109/bibm.2016.7822484","mag":"2576351525"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2016.7822484","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822484","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100402348","display_name":"Xiangdong Wang","orcid":"https://orcid.org/0000-0002-8406-7928"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangdong Wang","raw_affiliation_strings":["Fudan University, China","Fudan University, Shanghai, Shanghai, CN"],"affiliations":[{"raw_affiliation_string":"Fudan University, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Fudan University, Shanghai, Shanghai, CN","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100402348"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15100738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"11","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9645000100135803,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.95660001039505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6409800052642822},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5967329144477844},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5157268643379211},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4883517920970917},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.430447518825531},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3897554278373718},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3766161799430847},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24922463297843933},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2405020296573639},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1476331651210785}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6409800052642822},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5967329144477844},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5157268643379211},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4883517920970917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.430447518825531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3897554278373718},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3766161799430847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24922463297843933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2405020296573639},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1476331651210785}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2016.7822484","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822484","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5099999904632568,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967821671","https://openalex.org/W3030842346","https://openalex.org/W4200407670","https://openalex.org/W1969795570","https://openalex.org/W2125789691","https://openalex.org/W2063781606","https://openalex.org/W4290263427","https://openalex.org/W2304396134","https://openalex.org/W2266238929","https://openalex.org/W3144756874"],"abstract_inverted_index":{"Tomorrow's":[0],"genome":[1,75,107],"medicine":[2],"in":[3,22,74,91,113,171],"lung":[4,15,51,66,86,92,114,130],"cancer":[5,16,52,93,115,131],"should":[6],"focus":[7],"more":[8],"on":[9],"the":[10,23,48,56,63,172],"homogeneity":[11],"and":[12,34,39,43,62,77,83,123,126,159,178],"heterogeneity":[13,57],"of":[14,25,36,50,65,81,85,106,128,143,151],"which":[17],"play":[18],"an":[19,139],"important":[20],"role":[21],"development":[24],"drug":[26,60],"resistance,":[27,61],"genetic":[28],"complexity,":[29],"as":[30,32,104],"well":[31],"confusion":[33],"difficulty":[35],"early":[37],"diagnosis":[38],"therapy.":[40],"Chromosome":[41,89],"positioning":[42,125],"repositioning":[44],"may":[45],"contribute":[46],"to":[47,54,116,137,146,168],"sensitivity":[49],"cells":[53,145],"therapy,":[55],"associated":[58],"with":[59],"mechanism":[64],"carcinogenesis.":[67],"The":[68],"CCCTC-binding":[69],"factor":[70],"plays":[71],"critical":[72],"roles":[73],"topology":[76],"function,":[78],"increased":[79],"risk":[80,176],"carcinogenicity,":[82],"potential":[84],"cancer-specific":[87],"mediations.":[88],"reposition":[90],"can":[94,162],"be":[95,163],"regulated":[96],"by":[97],"CCCTC":[98],"binding":[99],"factor.":[100],"Single-cell":[101],"gene":[102],"sequencing,":[103],"part":[105],"medicine,":[108],"was":[109],"paid":[110],"special":[111],"attention":[112],"understand":[117],"mechanical":[118],"phenotypes,":[119],"single-cell":[120,141],"biology,":[121],"heterogeneity,":[122],"chromosome":[124],"function":[127],"single":[129],"cells.":[132],"We":[133],"at":[134],"first":[135],"propose":[136],"develop":[138],"intelligent":[140],"robot":[142],"human":[144],"integrate":[147],"together":[148],"systems":[149],"information":[150],"molecules,":[152],"genes,":[153],"proteins,":[154],"organelles,":[155],"membranes,":[156],"architectures,":[157],"signals,":[158],"functions.":[160],"It":[161],"a":[164],"powerful":[165],"automatic":[166],"system":[167],"assist":[169],"clinicians":[170],"decision-making,":[173],"molecular":[174],"understanding,":[175],"analyzing,":[177],"prognosis":[179],"predicting.":[180]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}