{"id":"https://openalex.org/W2218413617","doi":"https://doi.org/10.1109/bibm.2015.7359842","title":"Essential protein discovery based on network node correlation and invalidating protein node","display_name":"Essential protein discovery based on network node correlation and invalidating protein node","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2218413617","doi":"https://doi.org/10.1109/bibm.2015.7359842","mag":"2218413617"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2015.7359842","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359842","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018198927","display_name":"Wenjie Hu","orcid":"https://orcid.org/0000-0003-1795-1710"},"institutions":[{"id":"https://openalex.org/I4210106931","display_name":"Jiaxing Vocational Technical College","ror":"https://ror.org/02cydx698","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210106931"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjie Hu","raw_affiliation_strings":["College of Information Engineering, Xianning Vocational Technical College, Xianning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Xianning Vocational Technical College, Xianning, China","institution_ids":["https://openalex.org/I4210106931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101496385","display_name":"Xianjun Shen","orcid":"https://orcid.org/0000-0001-5714-8848"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianjun Shen","raw_affiliation_strings":["School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606983","display_name":"Rui Xu","orcid":"https://orcid.org/0000-0001-6512-7027"},"institutions":[{"id":"https://openalex.org/I4210163247","display_name":"Henan Institute of Science and Technology","ror":"https://ror.org/0578f1k82","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163247"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Xu","raw_affiliation_strings":["College of Information Engineering, Henan Institute of Science and Technology, Xinxiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Henan Institute of Science and Technology, Xinxiang, China","institution_ids":["https://openalex.org/I4210163247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":null,"first_page":"1141","last_page":"1147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.7739815711975098},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.7523922324180603},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6160995364189148},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.5894957780838013},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5365970134735107},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.44975537061691284},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4387189745903015},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.33870869874954224},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18300598859786987},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16323521733283997},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.13790154457092285},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11180856823921204}],"concepts":[{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.7739815711975098},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.7523922324180603},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6160995364189148},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.5894957780838013},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5365970134735107},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.44975537061691284},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4387189745903015},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.33870869874954224},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18300598859786987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16323521733283997},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13790154457092285},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11180856823921204},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2015.7359842","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359842","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2017975254","https://openalex.org/W2081931663","https://openalex.org/W2082649645","https://openalex.org/W2087194317","https://openalex.org/W2088062845","https://openalex.org/W2119114096","https://openalex.org/W2130790725","https://openalex.org/W2149055390","https://openalex.org/W2150066952","https://openalex.org/W2154600255","https://openalex.org/W2163480486"],"related_works":["https://openalex.org/W4229078645","https://openalex.org/W1977345676","https://openalex.org/W4282032776","https://openalex.org/W2047552823","https://openalex.org/W4321606905","https://openalex.org/W3130445735","https://openalex.org/W2105110616","https://openalex.org/W4297905891","https://openalex.org/W2169890516","https://openalex.org/W4323542959"],"abstract_inverted_index":{"Essential":[0],"proteins":[1,37,113],"are":[2],"indispensable":[3],"to":[4,14,62,95],"support":[5],"a":[6,105],"cell":[7],"function":[8,114],"that":[9,111,125],"provides":[10],"an":[11],"effective":[12],"way":[13],"analyze":[15],"the":[16,33,43,46,55,72,87,142],"critical":[17],"activities":[18],"and":[19,41,60,76,138,140],"processing":[20],"in":[21,38,116,145],"protein-protein":[22],"interaction.":[23],"By":[24],"means":[25],"of":[26,35,48,57,89,99,108],"deleting":[27],"essential":[28,36,109],"protein,":[29],"we":[30,103],"can":[31],"evaluate":[32],"importance":[34],"PPIs":[39],"before":[40],"after":[42],"events,":[44],"However,":[45],"elimination":[47],"protein":[49,66,110],"node":[50],"method":[51],"(EPNM)":[52],"would":[53],"destroy":[54],"topology":[56,91],"PPI":[58,100],"network":[59,90],"effect":[61],"exactly":[63],"assess":[64],"other":[65],"node.":[67],"Therefore,":[68],"this":[69],"paper":[70],"proposes":[71],"Network":[73],"Node":[74,79],"Correlation":[75],"Invalidating":[77],"Protein":[78],"(NNCIP)":[80],"Algorithm":[81],"which":[82],"is":[83],"not":[84],"only":[85],"keep":[86],"integrity":[88],"but":[92],"also":[93],"consider":[94],"local":[96],"correlated":[97],"behaviors":[98],"network.":[101],"Furthermore,":[102],"define":[104],"novel":[106],"measure":[107],"describes":[112],"decomposed":[115],"biological":[117],"cells":[118],"division":[119],"process.":[120],"The":[121],"experimental":[122],"results":[123],"showed":[124],"NNCIP":[126],"performs":[127],"significantly":[128],"better":[129],"than":[130],"classical":[131],"centrality":[132],"measures":[133],"DC,":[134],"CC,":[135],"BC,":[136],"EC":[137],"WCC,":[139],"has":[141],"obvious":[143],"advantage":[144],"predicted":[146],"accuracy.":[147]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
