{"id":"https://openalex.org/W2204097572","doi":"https://doi.org/10.1109/bibm.2015.7359699","title":"A test for detecting differentially methylated regions","display_name":"A test for detecting differentially methylated regions","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2204097572","doi":"https://doi.org/10.1109/bibm.2015.7359699","mag":"2204097572"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2015.7359699","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359699","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001526423","display_name":"Iksoo Huh","orcid":"https://orcid.org/0000-0003-2472-9501"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Iksoo Huh","raw_affiliation_strings":["Department of statistics, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of statistics, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084213906","display_name":"Soojin V. Yi","orcid":"https://orcid.org/0000-0003-1497-1871"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soojin V. Yi","raw_affiliation_strings":["School of Biology Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643662","display_name":"Taesung Park","orcid":"https://orcid.org/0000-0002-8294-590X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taesung Park","raw_affiliation_strings":["Department of statistics, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of statistics, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10599793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":null,"first_page":"305","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9865999817848206,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylated-dna-immunoprecipitation","display_name":"Methylated DNA immunoprecipitation","score":0.9393343925476074},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7671939134597778},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6554945111274719},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6279848217964172},{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"Differentially methylated regions","score":0.5884390473365784},{"id":"https://openalex.org/keywords/bisulfite-sequencing","display_name":"Bisulfite sequencing","score":0.5608221292495728},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5370577573776245},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5127586126327515},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.464221715927124},{"id":"https://openalex.org/keywords/epigenomics","display_name":"Epigenomics","score":0.46285903453826904},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.41741225123405457},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40606385469436646},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.40346747636795044},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3590133786201477},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34948134422302246},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.27341997623443604}],"concepts":[{"id":"https://openalex.org/C116114238","wikidata":"https://www.wikidata.org/wiki/Q6823960","display_name":"Methylated DNA immunoprecipitation","level":5,"score":0.9393343925476074},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7671939134597778},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6554945111274719},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6279848217964172},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.5884390473365784},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.5608221292495728},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5370577573776245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5127586126327515},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.464221715927124},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.46285903453826904},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.41741225123405457},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40606385469436646},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.40346747636795044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3590133786201477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34948134422302246},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27341997623443604}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2015.7359699","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359699","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1522996100","https://openalex.org/W1582030261","https://openalex.org/W1991656070","https://openalex.org/W2014530124","https://openalex.org/W2027236454","https://openalex.org/W2034074003","https://openalex.org/W2037207156","https://openalex.org/W2041674913","https://openalex.org/W2061076014","https://openalex.org/W2072249518","https://openalex.org/W2077248943","https://openalex.org/W2077406790","https://openalex.org/W2111857389","https://openalex.org/W2124359985","https://openalex.org/W2130535352","https://openalex.org/W2150000105","https://openalex.org/W2330813625","https://openalex.org/W6653881643"],"related_works":["https://openalex.org/W4233664389","https://openalex.org/W1480390089","https://openalex.org/W2127540087","https://openalex.org/W4319927080","https://openalex.org/W2094827321","https://openalex.org/W2008284862","https://openalex.org/W2033244804","https://openalex.org/W2163125553","https://openalex.org/W3038469736","https://openalex.org/W2099688182"],"abstract_inverted_index":{"DNA":[0,13,23,65],"methylation":[1,14],"is":[2,117],"one":[3,52],"of":[4,34,39,53,157,160],"the":[5,12,21,59,63,73,78,85,113],"most":[6,118],"important":[7,54],"phenomena":[8],"in":[9,56],"epigenetics.":[10,57],"Because":[11],"process":[15],"regulates":[16],"gene":[17,80],"expression":[18,81],"without":[19],"altering":[20],"corresponding":[22],"sequences,":[24],"it":[25,139,152],"can":[26],"explain":[27],"many":[28],"biological":[29],"processes":[30],"such":[31],"as":[32],"onset":[33],"cancer,":[35],"aging,":[36],"and":[37,137],"differentiation":[38],"species.":[40],"Therefore,":[41],"detecting":[42,163],"differentially":[43],"methylated":[44,64],"region":[45],"(DMR)":[46],"between":[47,144],"groups":[48],"has":[49,71],"been":[50],"considered":[51],"analyses":[55],"For":[58],"datasets":[60,86],"generated":[61,87],"by":[62,88,140],"immunoprecipitation":[66],"(MeDIP)":[67],"technique,":[68],"DMR":[69,109,126,164],"analysis":[70,110],"employed":[72],"previous":[74],"methods":[75,105],"developed":[76],"for":[77,84,108,128,162],"microarray-based":[79],"dataset.":[82],"However,":[83],"more":[89],"recent":[90],"bisulfite-sequencing":[91],"(BS-seq)":[92],"technologies,":[93],"totally":[94],"different":[95],"approaches":[96],"need":[97],"to":[98,153],"be":[99],"used.":[100,120],"Unfortunately,":[101],"only":[102],"a":[103,124,154],"few":[104],"are":[106],"available":[107],"among":[111],"which":[112],"Fisher's":[114],"exact":[115],"test":[116,127,136],"widely":[119],"We":[121],"first":[122],"propose":[123],"new":[125],"BS-seq":[129],"data.":[130],"Our":[131],"approach":[132],"employs":[133],"Cochran-Mantel-Hantzel":[134],"(CMH)":[135],"extend":[138],"incorporating":[141],"correlation":[142],"structures":[143],"adjacent":[145],"CpG":[146],"cytosine":[147],"sites.":[148],"Then":[149],"we":[150],"apply":[151],"real":[155],"dataset":[156],"two":[158],"subspecies":[159],"honeybee":[161],"regions.":[165]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}