{"id":"https://openalex.org/W2206052936","doi":"https://doi.org/10.1109/bibm.2015.7359693","title":"An efficient method to identify essential proteins for different species by integrating protein subcellular localization information","display_name":"An efficient method to identify essential proteins for different species by integrating protein subcellular localization information","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2206052936","doi":"https://doi.org/10.1109/bibm.2015.7359693","mag":"2206052936"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2015.7359693","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359693","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103182832","display_name":"Xiaoqing Peng","orcid":"https://orcid.org/0000-0002-4099-5183"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqing Peng","raw_affiliation_strings":["School of Information Science and Engineering, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438360","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0003-1516-0480"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Information Science and Engineering, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033371544","display_name":"Jiancheng Zhong","orcid":"https://orcid.org/0000-0001-6334-9304"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiancheng Zhong","raw_affiliation_strings":["School of Information Science and Engineering, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112011130","display_name":"Junwei Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junwei Luo","raw_affiliation_strings":["School of Information Science and Engineering, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101465265","display_name":"Yi Pan","orcid":"https://orcid.org/0000-0002-2766-3096"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yi Pan","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA","School of Information Science and Engineering, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]},{"raw_affiliation_string":"School of Information Science and Engineering, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.4153,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.97711996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"277","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"Subcellular localization","score":0.6542637944221497},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6409313082695007},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.6231048107147217},{"id":"https://openalex.org/keywords/homo-sapiens","display_name":"Homo sapiens","score":0.5979043841362},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.5807143449783325},{"id":"https://openalex.org/keywords/protein-subcellular-localization-prediction","display_name":"Protein subcellular localization prediction","score":0.5186837911605835},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4886520206928253},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44443950057029724},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18950879573822021},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18135705590248108}],"concepts":[{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.6542637944221497},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6409313082695007},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.6231048107147217},{"id":"https://openalex.org/C2777938546","wikidata":"https://www.wikidata.org/wiki/Q5","display_name":"Homo sapiens","level":2,"score":0.5979043841362},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5807143449783325},{"id":"https://openalex.org/C140051345","wikidata":"https://www.wikidata.org/wiki/Q7251501","display_name":"Protein subcellular localization prediction","level":3,"score":0.5186837911605835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4886520206928253},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44443950057029724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18950879573822021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18135705590248108},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2015.7359693","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359693","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326217","display_name":"Hunan Provincial Innovation Foundation for Postgraduate","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1571220527","https://openalex.org/W1973758399","https://openalex.org/W1986310535","https://openalex.org/W1999808266","https://openalex.org/W2007245700","https://openalex.org/W2017975254","https://openalex.org/W2074443723","https://openalex.org/W2082202339","https://openalex.org/W2087194317","https://openalex.org/W2088590769","https://openalex.org/W2089125183","https://openalex.org/W2097520363","https://openalex.org/W2105089945","https://openalex.org/W2113553645","https://openalex.org/W2115746733","https://openalex.org/W2119114096","https://openalex.org/W2130790725","https://openalex.org/W2137335580","https://openalex.org/W2155019453","https://openalex.org/W2163485494","https://openalex.org/W2201354711","https://openalex.org/W6677303926"],"related_works":["https://openalex.org/W2351398203","https://openalex.org/W4205775722","https://openalex.org/W2402975874","https://openalex.org/W3215969703","https://openalex.org/W4389024241","https://openalex.org/W2384565783","https://openalex.org/W2406531951","https://openalex.org/W2099701744","https://openalex.org/W3000696438","https://openalex.org/W1530366416"],"abstract_inverted_index":{"Essential":[0],"proteins":[1,33,67,146,166],"are":[2,28],"indispensable":[3],"to":[4,30,64,128,163],"maintain":[5],"life":[6],"activities":[7],"in":[8,15,52],"living":[9],"organisms,":[10],"and":[11,22,87,90,109,115,150],"play":[12],"important":[13],"roles":[14],"the":[16,43,91,102,110,142],"studies":[17],"of":[18,46,93,144,147],"pathology,":[19],"synthetic":[20],"biology,":[21],"drug":[23],"design.":[24],"Many":[25],"computational":[26],"methods":[27,104,138],"employed":[29],"identify":[31,164],"essential":[32,66,130,145,165],"from":[34,137],"Protein-protein":[35],"Interaction":[36],"Networks":[37],"(PINs).":[38],"In":[39],"this":[40],"paper,":[41],"considering":[42],"different":[44,53,136,168],"importance":[45],"protein-protein":[47],"interactions":[48],"which":[49,139],"take":[50],"place":[51],"subcellular":[54,71],"compartments,":[55],"a":[56,159],"Compartment":[57],"Importance":[58],"Centrality":[59],"(CIC)":[60],"method":[61,124],"is":[62],"proposed":[63],"detect":[65],"by":[68],"integrating":[69],"protein":[70,131],"localization":[72],"information.":[73],"The":[74,119],"experiments":[75],"were":[76],"carried":[77],"on":[78,107,132],"four":[79,133],"species":[80,149],"(Saccharomyces":[81],"cerevisiae,":[82],"Homo":[83],"sapiens,":[84],"Mus":[85],"musculus":[86],"Drosophila":[88],"melanogaster),":[89],"performance":[92,127],"CIC":[94,123,157],"was":[95],"compared":[96],"with":[97,141],"other":[98,116,155],"centrality":[99,103],"methods,":[100],"including":[101],"solely":[105],"based":[106],"topology":[108,114],"ones":[111],"combining":[112],"both":[113],"biological":[117],"knowledge.":[118],"results":[120],"show":[121],"that":[122],"has":[125,158],"better":[126],"predict":[129],"species.":[134,169],"Furthermore,":[135],"overfits":[140],"features":[143],"one":[148],"may":[151],"perform":[152],"poor":[153],"for":[154,167],"species,":[156],"wide":[160],"applicable":[161],"scope":[162]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}