{"id":"https://openalex.org/W2205765017","doi":"https://doi.org/10.1109/bibm.2015.7359689","title":"Principle Angle Enrichment Analysis (PAEA): Dimensionally reduced multivariate gene set enrichment analysis tool","display_name":"Principle Angle Enrichment Analysis (PAEA): Dimensionally reduced multivariate gene set enrichment analysis tool","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2205765017","doi":"https://doi.org/10.1109/bibm.2015.7359689","mag":"2205765017","pmid":"https://pubmed.ncbi.nlm.nih.gov/26848405"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2015.7359689","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359689","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737646","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068021572","display_name":"Neil R. Clark","orcid":"https://orcid.org/0000-0002-1844-0915"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neil R. Clark","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":[]},{"raw_affiliation_string":"Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":["https://openalex.org/I178645029"]},{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024851828","display_name":"Maciej Szymkiewicz","orcid":"https://orcid.org/0000-0003-1469-9396"},"institutions":[{"id":"https://openalex.org/I4210129007","display_name":"Warsaw School of Information Technology","ror":"https://ror.org/02wbgfm85","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210129007","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"funder","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maciej Szymkiewicz","raw_affiliation_strings":["Warsaw School of Information Technology under the auspices of the Polish Academy of Sciences, 6 Newelska St., 01-447, Warsaw, Poland","Warsaw School of Information Technology under the auspices of the Polish Academy of Sciences, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Warsaw School of Information Technology under the auspices of the Polish Academy of Sciences, 6 Newelska St., 01-447, Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"Warsaw School of Information Technology under the auspices of the Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210129007","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784336","display_name":"Zichen Wang","orcid":"https://orcid.org/0000-0002-1415-1286"},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zichen Wang","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA","Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007392907","display_name":"Caroline D. Monteiro","orcid":null},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline D. Monteiro","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA","Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001432390","display_name":"Matthew R. Jones","orcid":"https://orcid.org/0000-0002-4822-157X"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Jones","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA","Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032951414","display_name":"Avi Ma\u2019ayan","orcid":"https://orcid.org/0000-0002-6904-1017"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avi Ma'ayan","raw_affiliation_strings":["Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, NY, 10029, USA; Big Data to Knowledge (BD2K) Library of Integrated Network-based Cellular Signatures (LINCS) Data Coordination and Integration Center (DCIC); Mount Sinai Knowledge Management Center (KMC) for Illuminating the Druggable Genome (IDG)","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, New York, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068021572"],"corresponding_institution_ids":["https://openalex.org/I178645029","https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":1.205,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.79304322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2015","issue":null,"first_page":"256","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.9110766649246216},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.7039991617202759},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6714212894439697},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.6354376077651978},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.6129788756370544},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5323268175125122},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.47052112221717834},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4068090617656708},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.30835700035095215},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23115459084510803}],"concepts":[{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.9110766649246216},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.7039991617202759},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6714212894439697},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.6354376077651978},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.6129788756370544},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5323268175125122},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.47052112221717834},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4068090617656708},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30835700035095215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23115459084510803},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/bibm.2015.7359689","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359689","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmid:26848405","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26848405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Conference on Bioinformatics and Biomedicine","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4737646","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737646","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings (IEEE Int Conf Bioinformatics Biomed)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4737646","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737646","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings (IEEE Int Conf Bioinformatics Biomed)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4699999988079071}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1874647745","https://openalex.org/W1979369962","https://openalex.org/W1983463159","https://openalex.org/W2005989770","https://openalex.org/W2020859582","https://openalex.org/W2027895157","https://openalex.org/W2028815852","https://openalex.org/W2055666215","https://openalex.org/W2059005938","https://openalex.org/W2070050178","https://openalex.org/W2098023402","https://openalex.org/W2118069309","https://openalex.org/W2130410032","https://openalex.org/W2130666470","https://openalex.org/W2133465414","https://openalex.org/W2135415614","https://openalex.org/W2138133187","https://openalex.org/W2141703917","https://openalex.org/W2148268384","https://openalex.org/W2161027523","https://openalex.org/W2914060790","https://openalex.org/W6657746283"],"related_works":["https://openalex.org/W2579148721","https://openalex.org/W2347335694","https://openalex.org/W2091056927","https://openalex.org/W4387893611","https://openalex.org/W2067407580","https://openalex.org/W2038514069","https://openalex.org/W4389669152","https://openalex.org/W1967233468","https://openalex.org/W2009181529","https://openalex.org/W4250857377"],"abstract_inverted_index":{"Gene":[0],"set":[1,48,115,135,163,186],"analysis":[2,49,116,164],"of":[3,22,29,32,39,60,70,101,141],"differential":[4,85,102],"expression,":[5],"which":[6,87,117,182],"identifies":[7],"collectively":[8],"differentially":[9],"expressed":[10],"gene":[11,47,103,114,134,162,185],"sets,":[12],"has":[13,109,144],"become":[14],"an":[15],"important":[16],"tool":[17],"for":[18,133,161],"biology.":[19],"The":[20,172],"power":[21],"this":[23,107,142],"approach":[24,83,108,132],"lies":[25],"in":[26,57,90],"its":[27,37,149],"reduction":[28,128],"the":[30,33,58,68,97,139,193],"dimensionality":[31,127],"statistical":[34],"problem":[35],"and":[36,93,129,166,188],"incorporation":[38],"biological":[40,62],"interpretation":[41],"by":[42],"construction.":[43],"Many":[44],"approaches":[45],"to":[46,67,84,96,113,192],"have":[50],"been":[51,146],"proposed,":[52],"but":[53],"benchmarking":[54,91,159],"their":[55],"performance":[56,140],"setting":[59],"real":[61],"data":[63],"is":[64,175,189],"difficult":[65],"due":[66],"lack":[69],"a":[71,75,81,110,130,152,178],"gold":[72],"standard.":[73],"In":[74],"previously":[76],"published":[77],"work":[78],"we":[79,118,156],"proposed":[80],"geometrical":[82],"expression":[86],"performed":[88],"highly":[89],"tests":[92],"compared":[94],"well":[95],"most":[98],"popular":[99],"methods":[100,165],"expression.":[104],"As":[105],"reported,":[106],"natural":[111],"extension":[112],"call":[119],"Principal":[120],"Angle":[121],"Enrichment":[122],"Analysis":[123],"(PAEA).":[124],"PAEA":[125,169,173],"employs":[126],"multivariate":[131],"enrichment":[136],"analysis.":[137],"However,":[138],"method":[143,174],"not":[145],"assessed":[147],"nor":[148],"implementation":[150],"as":[151,177],"web-based":[153,180],"tool.":[154],"Here":[155],"describe":[157],"new":[158],"protocols":[160],"find":[167],"that":[168],"performs":[170],"highly.":[171],"implemented":[176],"user-friendly":[179],"tool,":[181],"contains":[183],"70":[184],"libraries":[187],"freely":[190],"available":[191],"community.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2016-06-24T00:00:00"}
