{"id":"https://openalex.org/W2206647586","doi":"https://doi.org/10.1109/bibm.2015.7359677","title":"EpiTracer - an algorithm for identifying epicenters in condition-specific biological networks","display_name":"EpiTracer - an algorithm for identifying epicenters in condition-specific biological networks","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2206647586","doi":"https://doi.org/10.1109/bibm.2015.7359677","mag":"2206647586"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2015.7359677","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359677","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066790241","display_name":"Narmada Sambaturu","orcid":"https://orcid.org/0000-0002-2570-3699"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narmada Sambaturu","raw_affiliation_strings":["IISc Mathematics Initiative, Indian Institute of Science, Bangalore, India"],"affiliations":[{"raw_affiliation_string":"IISc Mathematics Initiative, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085492874","display_name":"Madhulika Mishra","orcid":"https://orcid.org/0000-0001-7133-4743"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhulika Mishra","raw_affiliation_strings":["Department of Biochemistry, Indian Institute of Science, Bangalore, India"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085789773","display_name":"Nagasuma Chandra","orcid":"https://orcid.org/0000-0002-9939-8439"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nagasuma Chandra","raw_affiliation_strings":["IISc Mathematics Initiative, Indian Institute of Science, Bangalore, India"],"affiliations":[{"raw_affiliation_string":"IISc Mathematics Initiative, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066790241"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":null,"apc_paid":null,"fwci":0.3018,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62957754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"177","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.855889081954956},{"id":"https://openalex.org/keywords/ripple","display_name":"Ripple","score":0.7759740352630615},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6076304316520691},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.46901315450668335},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.44994157552719116},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.44057339429855347},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4390031695365906},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3990505337715149},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17688950896263123},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09372028708457947}],"concepts":[{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.855889081954956},{"id":"https://openalex.org/C2779599953","wikidata":"https://www.wikidata.org/wiki/Q1776117","display_name":"Ripple","level":3,"score":0.7759740352630615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6076304316520691},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.46901315450668335},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.44994157552719116},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.44057339429855347},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4390031695365906},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3990505337715149},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17688950896263123},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09372028708457947},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm.2015.7359677","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359677","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:eprints.iisc.ac.in:54510","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Conference Proceedings"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1484040084","https://openalex.org/W1967570846","https://openalex.org/W1968880423","https://openalex.org/W1986422297","https://openalex.org/W1990849705","https://openalex.org/W1997707189","https://openalex.org/W2009627530","https://openalex.org/W2020541351","https://openalex.org/W2053129716","https://openalex.org/W2053733974","https://openalex.org/W2070704205","https://openalex.org/W2080310417","https://openalex.org/W2083045667","https://openalex.org/W2118258530","https://openalex.org/W2131848047","https://openalex.org/W2133131640","https://openalex.org/W2146980885","https://openalex.org/W2147331022","https://openalex.org/W2153032620","https://openalex.org/W2162143298","https://openalex.org/W2169528473","https://openalex.org/W2169589032","https://openalex.org/W2170989872","https://openalex.org/W2335271138"],"related_works":["https://openalex.org/W4229078645","https://openalex.org/W1977345676","https://openalex.org/W4282032776","https://openalex.org/W2047552823","https://openalex.org/W4321606905","https://openalex.org/W3130445735","https://openalex.org/W2105110616","https://openalex.org/W2747930654","https://openalex.org/W2739658809","https://openalex.org/W2419362237"],"abstract_inverted_index":{"Diseases":[0],"in":[1,9,50,56,79,140,164,181],"biological":[2],"systems":[3,39],"may":[4],"result":[5],"from":[6,71],"small":[7,22],"perturbations":[8,18,44],"a":[10,21,32,47,51,73,86,96,99,126,130,197],"complex":[11,52],"network":[12],"of":[13,24,35,54,76,169,177,186,204,220],"protein-protein":[14],"interactions":[15],"(PPIs).":[16],"The":[17],"typically":[19],"affect":[20],"set":[23],"proteins,":[25,68],"which":[26,64,72],"then":[27],"go":[28],"on":[29,129],"to":[30,41,120],"disturb":[31],"larger":[33],"part":[34],"the":[36,57,66,77,105,121,134,148,160,165,170,184,193,205],"network.":[37,123],"Biological":[38],"attempt":[40],"counteract":[42],"these":[43],"by":[45,107,115],"launching":[46],"stress-response,":[48],"resulting":[49],"pattern":[53],"variations":[55],"cell.":[58],"We":[59,84,124,153,199],"present":[60],"an":[61],"algorithm,":[62],"EpiTracer":[63,156],"identifies":[65,157],"key":[67],"termed":[69],"epicenters,":[70],"large":[74],"number":[75],"changes":[78],"PPI":[80,122],"networks":[81],"ripple":[82,90,103],"out.":[83],"propose":[85],"new":[87],"centrality":[88],"measure,":[89],"centrality,":[91],"that":[92,155,175,192,202,215,223],"measures":[93],"how":[94],"effectively":[95],"change":[97],"at":[98],"particular":[100],"protein":[101],"can":[102],"across":[104],"network,":[106],"identifying":[108],"condition":[109],"specific":[110],"highest":[111],"activity":[112,185],"paths":[113],"obtained":[114],"mapping":[116],"gene":[117,135],"expression":[118,226],"profiles":[119],"perform":[125],"case":[127],"study":[128],"dataset":[131],"(E-GEOD-61973)":[132],"where":[133],"PARK2":[136,158,187],"was":[137],"intentionally":[138],"overexpressed":[139],"human":[141],"glioma":[142],"(U251)":[143],"cell":[144,194],"line":[145],"and":[146],"analyze":[147],"top":[149],"10":[150],"ranked":[151],"epicenters.":[152],"find":[154,201],"as":[159],"most":[161],"important":[162],"epicenter":[163],"perturbed":[166],"condition.":[167],"Analysis":[168],"other":[171],"top-ranked":[172],"epicenters":[173,207],"showed":[174],"all":[176],"them":[178],"were":[179],"involved":[180],"either":[182],"supporting":[183],"or":[188],"counteracting":[189],"it,":[190],"indicating":[191],"had":[195],"activated":[196],"stress-response.":[198],"also":[200],"5":[203],"identified":[206],"did":[208],"not":[209],"have":[210],"significant":[211],"differential":[212,225],"expression,":[213],"proving":[214],"our":[216],"method":[217],"is":[218],"capable":[219],"finding":[221],"information":[222],"simple":[224],"analysis":[227],"cannot.":[228]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
