{"id":"https://openalex.org/W2208030221","doi":"https://doi.org/10.1109/bibm.2015.7359673","title":"A novel two-stage method for identifying microRNA-gene regulatory modules in breast cancer","display_name":"A novel two-stage method for identifying microRNA-gene regulatory modules in breast cancer","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2208030221","doi":"https://doi.org/10.1109/bibm.2015.7359673","mag":"2208030221"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2015.7359673","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359673","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083513047","display_name":"Wenwen Min","orcid":"https://orcid.org/0000-0002-2558-2911"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenwen Min","raw_affiliation_strings":["School of Computer, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446290","display_name":"Juan Liu","orcid":"https://orcid.org/0000-0001-9344-7415"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["School of Computer, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066141529","display_name":"Fei Luo","orcid":"https://orcid.org/0000-0002-4326-6015"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Luo","raw_affiliation_strings":["School of Computer, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Computer, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076619069","display_name":"Shihua Zhang","orcid":"https://orcid.org/0000-0003-0192-7118"},"institutions":[{"id":"https://openalex.org/I4210095018","display_name":"National Center for Mathematics and Interdisciplinary Sciences","ror":"https://ror.org/00s97k668","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210095018"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shihua Zhang","raw_affiliation_strings":["National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing, China"],"affiliations":[{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210095018","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083513047"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":null,"apc_paid":null,"fwci":0.3408,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61242244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":null,"first_page":"151","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8319994211196899},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7189180850982666},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6364612579345703},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6299115419387817},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5453320741653442},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5314150452613831},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.5067020058631897},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.46462541818618774},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.41713234782218933},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3773627281188965},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35599374771118164},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.351162850856781},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2979419231414795},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25770050287246704},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.08501127362251282}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8319994211196899},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7189180850982666},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6364612579345703},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6299115419387817},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5453320741653442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5314150452613831},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.5067020058631897},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.46462541818618774},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.41713234782218933},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3773627281188965},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35599374771118164},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.351162850856781},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2979419231414795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25770050287246704},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.08501127362251282},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2015.7359673","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2015.7359673","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1604021722","https://openalex.org/W1976050069","https://openalex.org/W1987371344","https://openalex.org/W1991128404","https://openalex.org/W2014946489","https://openalex.org/W2018908310","https://openalex.org/W2026570544","https://openalex.org/W2043920413","https://openalex.org/W2051680008","https://openalex.org/W2073737788","https://openalex.org/W2077327925","https://openalex.org/W2083381199","https://openalex.org/W2090219560","https://openalex.org/W2094720383","https://openalex.org/W2096283457","https://openalex.org/W2103151642","https://openalex.org/W2103570076","https://openalex.org/W2105136962","https://openalex.org/W2107180520","https://openalex.org/W2109761160","https://openalex.org/W2113390076","https://openalex.org/W2117968640","https://openalex.org/W2119106393","https://openalex.org/W2123157675","https://openalex.org/W2143693563","https://openalex.org/W2146777736","https://openalex.org/W2162674813","https://openalex.org/W6636311894"],"related_works":["https://openalex.org/W2971971174","https://openalex.org/W2128583238","https://openalex.org/W2134405083","https://openalex.org/W2049907435","https://openalex.org/W2034500416","https://openalex.org/W2010571965","https://openalex.org/W2034377088","https://openalex.org/W3128451840","https://openalex.org/W2002709996","https://openalex.org/W4387092964"],"abstract_inverted_index":{"In":[0],"this":[1,59],"paper,":[2],"we":[3,41],"propose":[4,42],"a":[5,26,43,91],"two-stage":[6],"method":[7,60],"for":[8],"identifying":[9],"miRNA-gene":[10,37,78,93,143],"regulatory":[11,38,79,94,144],"modules":[12,52,86,98,117,145],"by":[13],"integrating":[14],"miRNA/mRNA":[15],"expression":[16,65],"profiles":[17,66],"and":[18,63,75,106,113,129,157],"miRNA":[19,62],"genomic":[20],"cluster":[21],"data.":[22],"We":[23,57,81],"first":[24],"adopt":[25],"Multiple-output":[27],"Sparse":[28],"Group":[29],"Lasso":[30],"(MSGL)":[31],"regression":[32],"model":[33,49],"to":[34,50,61],"predict":[35],"the":[36,54,68,85,97,116,127,132,149,152],"network.":[39,56],"Further,":[40],"L0-penalized":[44],"Singular":[45],"Value":[46],"Decomposition":[47],"(L0-SVD)":[48],"identify":[51,76],"from":[53,72],"predicted":[55,92],"apply":[58],"mRNA":[64],"of":[67,126,131,151],"breast":[69,121,137],"cancer":[70],"data":[71],"TCGA":[73],"databases":[74],"ten":[77],"modules.":[80],"find":[82],"that":[83,142],"(1)":[84],"are":[87,99,118,134],"significantly":[88,100],"associated":[89],"in":[90,102,115],"network;":[95],"(2)":[96],"enriched":[101],"GO":[103],"biological":[104],"processes":[105],"KEGG":[107],"pathways,":[108],"respectively;":[109],"(3)":[110],"many":[111],"miRNAs":[112,128,156],"genes":[114,133],"related":[119,135],"with":[120,136],"cancer.":[122,138],"On":[123],"average,":[124],"51%":[125],"30%":[130],"The":[139],"results":[140],"demonstrate":[141],"provide":[146],"insights":[147],"into":[148],"mechanisms":[150],"combinatorial":[153],"regulation":[154],"between":[155],"genes.":[158]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}