{"id":"https://openalex.org/W1989237842","doi":"https://doi.org/10.1109/bibm.2014.6999366","title":"Fang-Feng-Tang's potential therapeutic agents for rheumatoid arthritis","display_name":"Fang-Feng-Tang's potential therapeutic agents for rheumatoid arthritis","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W1989237842","doi":"https://doi.org/10.1109/bibm.2014.6999366","mag":"1989237842"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2014.6999366","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2014.6999366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013506158","display_name":"Guang Zheng","orcid":"https://orcid.org/0000-0003-4118-7804"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guang Zheng","raw_affiliation_strings":["School of Information Science-Engineering, Lanzhou University, Lanzhou, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science-Engineering, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072550851","display_name":"Ting Hao","orcid":"https://orcid.org/0000-0003-4667-4556"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Hao","raw_affiliation_strings":["School of Information Science-Engineering, Lanzhou University, Lanzhou, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science-Engineering, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385064","display_name":"Rong Li","orcid":"https://orcid.org/0000-0003-0305-5579"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Li","raw_affiliation_strings":["School of Information Science-Engineering, Lanzhou University, Lanzhou, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science-Engineering, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102708482","display_name":"Lingru Wang","orcid":"https://orcid.org/0000-0002-6065-5389"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingru Wang","raw_affiliation_strings":["School of Information Science-Engineering, Lanzhou University, Lanzhou, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science-Engineering, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019225012","display_name":"Kai Cui","orcid":"https://orcid.org/0000-0002-6060-6130"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Cui","raw_affiliation_strings":["School of Information Science-Engineering, Lanzhou University, Lanzhou, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science-Engineering, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001858374","display_name":"Cheng L\u00fc","orcid":"https://orcid.org/0000-0002-6474-9198"},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Lu","raw_affiliation_strings":["IBRCM, China Academy of traditional Chinese medicines, Beijing, China"],"affiliations":[{"raw_affiliation_string":"IBRCM, China Academy of traditional Chinese medicines, Beijing, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076594495","display_name":"Aiping L\u00fc","orcid":"https://orcid.org/0000-0002-2303-0494"},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]},{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Aiping Lu","raw_affiliation_strings":["IBRCM, China Academy of traditional Chinese medicines, Beijing, China","Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong"],"affiliations":[{"raw_affiliation_string":"IBRCM, China Academy of traditional Chinese medicines, Beijing, China","institution_ids":["https://openalex.org/I4210157155"]},{"raw_affiliation_string":"Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I141568987"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013506158"],"corresponding_institution_ids":["https://openalex.org/I76214153"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07373643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":null,"first_page":"235","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"Rheumatoid arthritis","score":0.7278217077255249},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6815057396888733},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.6432745456695557},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5531175136566162},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5458401441574097},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.47185584902763367},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4680326282978058},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46448665857315063},{"id":"https://openalex.org/keywords/arthritis","display_name":"Arthritis","score":0.4301300644874573},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.3905330300331116},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.38154447078704834},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34417346119880676},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2870728671550751},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28069165349006653},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1760469675064087},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.110250324010849},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"Alternative medicine","score":0.07966184616088867}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7278217077255249},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6815057396888733},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.6432745456695557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5531175136566162},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5458401441574097},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47185584902763367},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4680326282978058},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46448665857315063},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4301300644874573},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3905330300331116},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38154447078704834},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34417346119880676},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2870728671550751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28069165349006653},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1760469675064087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.110250324010849},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07966184616088867},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/bibm.2014.6999366","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2014.6999366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/183780","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/183780","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u4f1a\u8bae\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/352980","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/352980","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conferences"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/303931","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/303931","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conferences"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/308765","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/308765","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conferences"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1995676426","https://openalex.org/W2010231396","https://openalex.org/W2052912923","https://openalex.org/W2064244909","https://openalex.org/W2070761998","https://openalex.org/W2096541451","https://openalex.org/W2108654637","https://openalex.org/W2110762994","https://openalex.org/W2119412782","https://openalex.org/W2348146091","https://openalex.org/W2401664371","https://openalex.org/W6663834912","https://openalex.org/W6712952066"],"related_works":["https://openalex.org/W2185550546","https://openalex.org/W2416097977","https://openalex.org/W2993678931","https://openalex.org/W2028766184","https://openalex.org/W2384738060","https://openalex.org/W3045583548","https://openalex.org/W812086887","https://openalex.org/W2101475263","https://openalex.org/W4312109267","https://openalex.org/W4386016105"],"abstract_inverted_index":{"Fang-Feng-Tang":[0],"is":[1,7,26],"a":[2,86,128],"Chinese":[3,138],"herbal":[4,59,139],"formula":[5],"which":[6],"designed":[8],"to":[9],"treat":[10],"syndrome":[11],"Feng-Han-Shi-Bi":[12],"for":[13,47,82],"rheumatoid":[14],"arthritis":[15],"(RA).":[16],"Although":[17],"its":[18,24],"therapeutic":[19,45,141],"effects":[20,142],"are":[21,70,95,106],"widely":[22],"accepted,":[23],"mechanism":[25,55],"still":[27],"obscure.":[28],"In":[29],"this":[30],"study,":[31],"by":[32],"integrating":[33],"leading":[34],"knowledge":[35],"databases":[36],"of":[37,111,131],"associated":[38],"different":[39,132],"domains,":[40],"we":[41],"explored":[42],"Fang-Feng-Tang's":[43],"potential":[44],"agents":[46],"RA":[48,73,79],"through":[49,146],"targeted":[50],"pathway":[51],"hierarchies.":[52],"The":[53],"molecule":[54],"analysis":[56],"includes":[57],"compositional":[58],"medicine,":[60],"chemical":[61],"compound,":[62],"target":[63,89,124],"protein,":[64],"and":[65,76,93,101,117],"pathways":[66,110],"enriched.":[67],"Target":[68],"proteins":[69,90,125],"restricted":[71],"with":[72],"OMIM":[74],"genes":[75,154],"FDA":[77],"approved":[78],"drug":[80],"targets":[81],"partial":[83],"validation.":[84],"As":[85],"result,":[87],"8":[88],"were":[91],"matched":[92],"they":[94,105],"UGT1A9,":[96],"GNT1,":[97],"UGT1,":[98],"JAK3,":[99],"CCR2/5,":[100],"CMKBR2/5.":[102],"What's":[103],"more,":[104],"mainly":[107],"involved":[108],"in":[109],"signal":[112],"transduction,":[113],"metabolism,":[114],"immune":[115],"system,":[116],"disease.":[118],"This":[119,134],"research":[120],"demonstrates":[121],"that":[122,137],"Feng-Feng-Tang's":[123],"may":[126],"regulate":[127],"wide":[129],"range":[130],"systems.":[133],"might":[135],"indicate":[136],"formula's":[140],"can":[143],"be":[144],"demonstrated":[145],"system-level":[147],"regulation":[148],"rather":[149],"than":[150],"targeting":[151],"disease":[152],"specified":[153],"or":[155],"proteins.":[156]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}