{"id":"https://openalex.org/W2009242379","doi":"https://doi.org/10.1109/bibm.2014.6999299","title":"Prediction of human disease-specific phosphorylation sites with combined feature selection approach and support vector machine","display_name":"Prediction of human disease-specific phosphorylation sites with combined feature selection approach and support vector machine","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2009242379","doi":"https://doi.org/10.1109/bibm.2014.6999299","mag":"2009242379"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2014.6999299","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2014.6999299","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028516138","display_name":"Xiaoyi Xu","orcid":"https://orcid.org/0000-0001-8432-6291"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyi Xu","raw_affiliation_strings":["School of Information Science and Technology, University of Science and Technology of China, Hefei, China","School of Information Science and Technology; University of Science and Technology of China; Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"School of Information Science and Technology; University of Science and Technology of China; Hefei China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359729","display_name":"Ao Li","orcid":"https://orcid.org/0000-0001-9910-8967"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ao Li","raw_affiliation_strings":["School of Information Science and Technology, University of Science and Technology of China, Hefei, China","School of Information Science and Technology; University of Science and Technology of China; Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"School of Information Science and Technology; University of Science and Technology of China; Hefei China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376897","display_name":"Minghui Wang","orcid":"https://orcid.org/0000-0002-0181-8467"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Wang","raw_affiliation_strings":["School of Information Science and Technology, University of Science and Technology of China, Hefei, China","School of Information Science and Technology; University of Science and Technology of China; Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"School of Information Science and Technology; University of Science and Technology of China; Hefei China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126520041"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"23","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.7850774526596069},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.708327054977417},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.6567474603652954},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5440685749053955},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49560558795928955},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.49206942319869995},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.47080859541893005},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40639787912368774},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40382903814315796},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36515551805496216},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24174001812934875},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09328821301460266}],"concepts":[{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.7850774526596069},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.708327054977417},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.6567474603652954},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5440685749053955},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49560558795928955},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.49206942319869995},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.47080859541893005},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40639787912368774},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40382903814315796},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36515551805496216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24174001812934875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09328821301460266}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2014.6999299","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2014.6999299","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6100000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W639801547","https://openalex.org/W1567394263","https://openalex.org/W1570204439","https://openalex.org/W1971369226","https://openalex.org/W1985085054","https://openalex.org/W1987122037","https://openalex.org/W1988520084","https://openalex.org/W1993450321","https://openalex.org/W1995240259","https://openalex.org/W2020459598","https://openalex.org/W2022446852","https://openalex.org/W2023389323","https://openalex.org/W2030205108","https://openalex.org/W2038163496","https://openalex.org/W2041652340","https://openalex.org/W2041811289","https://openalex.org/W2043794217","https://openalex.org/W2061351061","https://openalex.org/W2081497033","https://openalex.org/W2100984467","https://openalex.org/W2119387367","https://openalex.org/W2128941049","https://openalex.org/W2130277691","https://openalex.org/W2134129243","https://openalex.org/W2148633389","https://openalex.org/W2153635508","https://openalex.org/W2154053567","https://openalex.org/W2155239883","https://openalex.org/W2157658519","https://openalex.org/W2158266834","https://openalex.org/W2165594346","https://openalex.org/W2167573033","https://openalex.org/W2192273339","https://openalex.org/W2974222084"],"related_works":["https://openalex.org/W2090763504","https://openalex.org/W2367598447","https://openalex.org/W148178222","https://openalex.org/W2104657898","https://openalex.org/W1948992892","https://openalex.org/W1886884218","https://openalex.org/W4387217650","https://openalex.org/W3170994674","https://openalex.org/W1910826599","https://openalex.org/W2902850283"],"abstract_inverted_index":{"Phosphorylation":[0],"is":[1,71,86,122,137],"a":[2,67,105,164],"crucial":[3],"post":[4],"translational":[5],"modification,":[6],"which":[7],"regulates":[8],"almost":[9],"all":[10],"cellular":[11],"process":[12,116,121],"in":[13],"life.":[14],"It":[15],"has":[16,23],"long":[17],"been":[18],"recognized":[19],"that":[20,70,112,135],"protein":[21],"phosphorylation":[22,36,57,77,84,130],"close":[24],"relationship":[25],"with":[26],"diseases,":[27],"and":[28,41,91,117,149,173,188],"therefore":[29],"many":[30],"researches":[31],"are":[32,94],"undertaken":[33],"to":[34,74],"predict":[35,128],"sites":[37,58,78],"for":[38,61,96],"disease":[39],"treatment":[40],"drug":[42],"design.":[43],"However,":[44],"despite":[45],"the":[46,62,141,154,168,182],"success":[47],"achieved":[48],"by":[49],"these":[50],"approaches,":[51],"no":[52],"method":[53],"focuses":[54],"on":[55,80,179],"disease-associated":[56,83],"prediction.":[59],"Herein,":[60],"first":[63],"time":[64],"we":[65,126],"propose":[66],"novel":[68],"approach":[69],"specially":[72],"designed":[73],"identify":[75],"disease-specific":[76,129],"based":[79],"SVM.":[81],"Human":[82],"data":[85],"extracted":[87],"from":[88],"PhosphoSitePlus":[89],"database":[90],"local":[92],"sequences":[93],"derived":[95],"training.":[97],"To":[98],"take":[99],"full":[100],"advantage":[101],"of":[102,158,170,181,185],"sequence":[103],"information,":[104],"combined":[106],"feature":[107,119],"selection":[108,120],"method-based":[109],"SVM":[110],"(CFS-SVM)":[111],"incorporates":[113],"mRMR":[114],"filtering":[115],"forward":[118],"developed.":[123],"With":[124,153],"CFS-SVM,":[125],"successfully":[127],"sites.":[131],"Performance":[132],"evaluation":[133],"shows":[134],"CFS-SVM":[136,160],"significantly":[138],"better":[139],"than":[140],"widely":[142],"used":[143],"classifiers,":[144],"including":[145],"Bayesian":[146],"decision":[147],"theory":[148],"k":[150],"nearest":[151],"neighbour.":[152],"extremely":[155],"high":[156,165],"specificity":[157],"99%,":[159],"can":[161],"still":[162],"achieve":[163],"sensitivity.":[166],"Besides,":[167],"analysis":[169],"corresponding":[171],"kinases":[172],"selected":[174],"features":[175],"also":[176],"shed":[177],"light":[178],"understanding":[180],"potential":[183],"mechanism":[184],"disease-phosphorylation":[186],"relationships":[187],"guide":[189],"further":[190],"experimental":[191],"validations.":[192]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
