{"id":"https://openalex.org/W2071455570","doi":"https://doi.org/10.1109/bibm.2014.6999250","title":"Exploration of leukemia gene regulatory networks using a systems biology approach","display_name":"Exploration of leukemia gene regulatory networks using a systems biology approach","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2071455570","doi":"https://doi.org/10.1109/bibm.2014.6999250","mag":"2071455570"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2014.6999250","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2014.6999250","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052589632","display_name":"Dong Tong","orcid":"https://orcid.org/0000-0002-6363-7960"},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dong Ling Tong","raw_affiliation_strings":["The John van Geest Cancer Research Centre School of Science and Technology, Nottingham Trent University Nottingham, United Kingdom","The John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The John van Geest Cancer Research Centre School of Science and Technology, Nottingham Trent University Nottingham, United Kingdom","institution_ids":["https://openalex.org/I52590639"]},{"raw_affiliation_string":"The John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I52590639"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011811761","display_name":"Graham Ball","orcid":"https://orcid.org/0000-0001-5828-7129"},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham R Ball","raw_affiliation_strings":["The John van Geest Cancer Research Centre School of Science and Technology, Nottingham Trent University Nottingham, United Kingdom","The John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The John van Geest Cancer Research Centre School of Science and Technology, Nottingham Trent University Nottingham, United Kingdom","institution_ids":["https://openalex.org/I52590639"]},{"raw_affiliation_string":"The John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I52590639"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52590639"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.17475728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"286","issue":null,"first_page":"68","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.7415468096733093},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6810145378112793},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6423553228378296},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6180352568626404},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.569992184638977},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5080499649047852},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.45348259806632996},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4360382556915283},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42215728759765625},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18537330627441406},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17106115818023682},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.06884139776229858}],"concepts":[{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.7415468096733093},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6810145378112793},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6423553228378296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6180352568626404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.569992184638977},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5080499649047852},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45348259806632996},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4360382556915283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42215728759765625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18537330627441406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17106115818023682},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06884139776229858}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2014.6999250","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2014.6999250","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1754303883","https://openalex.org/W1970961996","https://openalex.org/W1976645012","https://openalex.org/W1994900858","https://openalex.org/W2009527232","https://openalex.org/W2046353917","https://openalex.org/W2046624437","https://openalex.org/W2047122678","https://openalex.org/W2049743072","https://openalex.org/W2051802475","https://openalex.org/W2054024237","https://openalex.org/W2057965467","https://openalex.org/W2073352439","https://openalex.org/W2088005751","https://openalex.org/W2097519948","https://openalex.org/W2105924489","https://openalex.org/W2109280977","https://openalex.org/W2109363337","https://openalex.org/W2113262318","https://openalex.org/W2138218344","https://openalex.org/W2140946267","https://openalex.org/W2146887040","https://openalex.org/W2155142785","https://openalex.org/W2161817637","https://openalex.org/W2162790428"],"related_works":["https://openalex.org/W5284979","https://openalex.org/W2949927938","https://openalex.org/W2029387041","https://openalex.org/W2135896045","https://openalex.org/W2032799661","https://openalex.org/W2996680049","https://openalex.org/W4245853730","https://openalex.org/W2884256268","https://openalex.org/W2131025197","https://openalex.org/W2799842390"],"abstract_inverted_index":{"Despite":[0],"extensive":[1],"studies":[2],"in":[3,7],"cytogenetic":[4],"and":[5,25,34,42],"mutations":[6],"leukemia":[8],"cancer,":[9],"new":[10],"diagnoses":[11],"were":[12,93],"detected":[13],"each":[14],"year.":[15],"This":[16],"is":[17],"due":[18],"to":[19,38,50,56,73],"multifactorial":[20],"characteristic":[21],"of":[22,28,44,61,68,83],"hematopoietic":[23],"disease":[24],"a":[26,52,69],"lack":[27],"systematic-level":[29],"information":[30,82],"on":[31],"genetic":[32,76],"interaction":[33],"pathways":[35],"between":[36],"markers":[37,87,92],"understand":[39],"the":[40,66,84],"development":[41],"progression":[43],"leukemia.":[45],"Thus,":[46],"this":[47],"study":[48],"aims":[49],"sought":[51],"systems":[53,70],"biology":[54,71],"approach":[55,72],"infer":[57],"gene":[58],"regulatory":[59],"networks":[60],"leukemia-related":[62],"markers.":[63],"Results":[64],"demonstrated":[65],"effectiveness":[67],"simplify":[74],"complex":[75],"interactions":[77],"without":[78],"losing":[79],"important":[80],"biological":[81],"genes.":[85],"Key":[86],"that":[88],"inter-connected":[89],"other":[90],"leukemia-associated":[91],"identified.":[94]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}