{"id":"https://openalex.org/W2003011887","doi":"https://doi.org/10.1109/bibm.2013.6732721","title":"Tumor subtype identification with weighted sparse non-negative matrix factorization for multiple heterogeneous data integration","display_name":"Tumor subtype identification with weighted sparse non-negative matrix factorization for multiple heterogeneous data integration","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2003011887","doi":"https://doi.org/10.1109/bibm.2013.6732721","mag":"2003011887"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2013.6732721","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732721","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441148","display_name":"Hyunsoo Kim","orcid":"https://orcid.org/0000-0002-8441-3376"},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyunsoo Kim","raw_affiliation_strings":["Jackson Laboratory for Genomic Medicine, Farmington, CT, USA","Jackson Lab. for Genomic Med., Farmington, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jackson Laboratory for Genomic Medicine, Farmington, CT, USA","institution_ids":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]},{"raw_affiliation_string":"Jackson Lab. for Genomic Med., Farmington, CT, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041985180","display_name":"Jeff Chuang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Chuang","raw_affiliation_strings":["Jackson Laboratory for Genomic Medicine, Farmington, CT, USA","Jackson Lab. for Genomic Med., Farmington, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jackson Laboratory for Genomic Medicine, Farmington, CT, USA","institution_ids":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]},{"raw_affiliation_string":"Jackson Lab. for Genomic Med., Farmington, CT, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068526964","display_name":"Markus Bredel","orcid":"https://orcid.org/0000-0002-7828-0984"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Bredel","raw_affiliation_strings":["Dept. of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA","Dept. of Radiat. Oncology, Univ. of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Dept. of Radiat. Oncology, Univ. of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.1185968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"14","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.8626384735107422},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.6642917394638062},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6001775860786438},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5796481370925903},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4062032401561737},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32509419322013855},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19987735152244568}],"concepts":[{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.8626384735107422},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.6642917394638062},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6001775860786438},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5796481370925903},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4062032401561737},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32509419322013855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19987735152244568},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2013.6732721","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732721","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46000000834465027,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1255676896","https://openalex.org/W1486625309","https://openalex.org/W1548779692","https://openalex.org/W1578099820","https://openalex.org/W1823022514","https://openalex.org/W1902027874","https://openalex.org/W1966331733","https://openalex.org/W2031912356","https://openalex.org/W2041440766","https://openalex.org/W2076566842","https://openalex.org/W2096283457","https://openalex.org/W2097255042","https://openalex.org/W2108119513","https://openalex.org/W2132538571","https://openalex.org/W2135046866","https://openalex.org/W2136787567","https://openalex.org/W2137085845","https://openalex.org/W2141781797","https://openalex.org/W2158146385","https://openalex.org/W2161289668","https://openalex.org/W2165685007","https://openalex.org/W2262414037","https://openalex.org/W2275877493","https://openalex.org/W4230962320","https://openalex.org/W6638577820"],"related_works":["https://openalex.org/W2127243424","https://openalex.org/W4390394189","https://openalex.org/W2037504162","https://openalex.org/W2539013788","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W34555840"],"abstract_inverted_index":{"Tumor":[0],"subtype":[1,34],"identification":[2,93],"is":[3,89],"an":[4],"important":[5],"topic":[6],"for":[7,14,28],"personalized":[8],"medicine":[9],"to":[10,66,91],"design":[11],"better":[12],"treatment":[13],"each":[15],"subcategory.":[16],"It":[17],"has":[18],"been":[19],"shown":[20],"that":[21],"non-negative":[22],"matrix":[23],"factorization":[24],"(NMF)":[25],"performs":[26],"well":[27],"many":[29],"practical":[30],"problems":[31],"including":[32],"tumor":[33,95],"identification.":[35],"However,":[36],"input":[37],"genes":[38],"can":[39],"also":[40],"affect":[41],"its":[42],"performance.":[43],"In":[44],"this":[45],"paper,":[46],"we":[47],"review":[48],"a":[49,57],"variation":[50],"of":[51,60,94,97],"sparse":[52,63],"NMF":[53,64],"(sNMF),":[54],"and":[55,83],"introduce":[56],"novel":[58],"algorithm":[59],"the":[61,92],"weighted":[62],"(wsNMF)":[65],"incorporate":[67],"known":[68],"biological":[69],"knowledge":[70],"by":[71],"integrating":[72],"multiple":[73],"heterogeneous":[74],"data":[75],"(e.g.,":[76],"gene":[77],"expression,":[78],"mutations,":[79],"protein-protein":[80],"interaction":[81],"network,":[82],"transcription":[84],"factor":[85],"target":[86],"network).":[87],"wsNMF":[88],"applied":[90],"subtypes":[96],"uterine":[98],"corpus":[99],"endometrial":[100],"carcinoma.":[101]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}