{"id":"https://openalex.org/W1990648971","doi":"https://doi.org/10.1109/bibm.2013.6732713","title":"eXtasy simplified-towards opening the black box","display_name":"eXtasy simplified-towards opening the black box","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W1990648971","doi":"https://doi.org/10.1109/bibm.2013.6732713","mag":"1990648971"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2013.6732713","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732713","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/handle/123456789/425749","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085611600","display_name":"Du\u0161an Popovi\u0107","orcid":"https://orcid.org/0000-0002-5912-0360"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dusan Popovic","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045411063","display_name":"Alejandro Sifrim","orcid":"https://orcid.org/0000-0001-8247-4020"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alejandro Sifrim","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041984163","display_name":"Yves Moreau","orcid":"https://orcid.org/0000-0002-4647-6560"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yves Moreau","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018814006","display_name":"Bart De Moor","orcid":"https://orcid.org/0000-0002-1154-5028"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bart De Moor","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS - iMinds Future Health Department KULeuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Dept. of Electr. Eng., KU Leuven, Leuven, , Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"24","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.776718020439148},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7277894020080566},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5458422899246216},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.504726767539978},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.48921728134155273},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4879979193210602},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.46334370970726013},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.43503570556640625},{"id":"https://openalex.org/keywords/speedup","display_name":"Speedup","score":0.42024195194244385},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41980358958244324},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4013071656227112}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.776718020439148},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7277894020080566},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5458422899246216},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.504726767539978},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48921728134155273},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4879979193210602},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.46334370970726013},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.43503570556640625},{"id":"https://openalex.org/C68339613","wikidata":"https://www.wikidata.org/wiki/Q1549489","display_name":"Speedup","level":2,"score":0.42024195194244385},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41980358958244324},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4013071656227112},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm.2013.6732713","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732713","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/425749","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/425749","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"IEEE BIBM 2013, Shanghai, China, December 2013","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/425749","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/425749","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"IEEE BIBM 2013, Shanghai, China, December 2013","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.49000000953674316}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1645738616","https://openalex.org/W1856006450","https://openalex.org/W1875061881","https://openalex.org/W1884926395","https://openalex.org/W1996031526","https://openalex.org/W1996964006","https://openalex.org/W2002579649","https://openalex.org/W2026740713","https://openalex.org/W2038132549","https://openalex.org/W2045164090","https://openalex.org/W2059145105","https://openalex.org/W2076357933","https://openalex.org/W2087588809","https://openalex.org/W2088203270","https://openalex.org/W2089903000","https://openalex.org/W2109555487","https://openalex.org/W2118246164","https://openalex.org/W2141307855","https://openalex.org/W2143238378","https://openalex.org/W2145187337","https://openalex.org/W2145191876","https://openalex.org/W2146841526","https://openalex.org/W2155445544","https://openalex.org/W2156332695","https://openalex.org/W2156868954","https://openalex.org/W2171777347","https://openalex.org/W2885727518","https://openalex.org/W2911964244","https://openalex.org/W6636995944","https://openalex.org/W6639512213"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2058965144","https://openalex.org/W2164382479","https://openalex.org/W4361806667","https://openalex.org/W2889302474"],"abstract_inverted_index":{"Exome":[0],"sequencing":[1],"remarkably":[2],"simplifies":[3],"the":[4,51,54,84,93,107],"search":[5],"for":[6],"mutations":[7],"causing":[8],"rare":[9],"monogenic":[10],"disorders.":[11],"Still,":[12],"due":[13],"to":[14,26],"a":[15,61,71,90],"big":[16],"number":[17],"of":[18,53,92,102],"potential":[19],"candidate":[20],"variants,":[21],"computational":[22],"methods":[23],"are":[24],"needed":[25],"facilitate":[27],"this":[28,42],"process.":[29,86],"Recently,":[30],"an":[31],"algorithm":[32,96],"based":[33,59],"on":[34,60],"genomic":[35],"data":[36],"fusion":[37],"has":[38],"been":[39],"proposed":[40],"in":[41,83],"context":[43],"(eXtasy),":[44],"which":[45],"exhibits":[46],"highly":[47],"competitive":[48],"performances":[49],"among":[50],"state":[52],"art":[55],"methods.":[56],"Nonetheless,":[57],"being":[58],"Random":[62],"Forest":[63],"classifier,":[64],"its":[65],"core":[66],"model":[67],"is":[68],"characterized":[69],"by":[70],"prohibitive":[72],"size,":[73],"slow":[74],"execution":[75],"speed":[76],"and":[77,111],"difficulties":[78],"associated":[79],"with":[80],"gaining":[81],"insights":[82],"decision-making":[85],"Here":[87],"we":[88],"propose":[89],"simplification":[91],"original":[94],"eXtasy":[95],"that":[97],"retains":[98],"superior":[99],"ranking":[100],"capability":[101],"former":[103],"without":[104],"suffering":[105],"from":[106],"both":[108],"high":[109],"complexity":[110],"low":[112],"interpretability.":[113]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
