{"id":"https://openalex.org/W2025643987","doi":"https://doi.org/10.1109/bibm.2013.6732711","title":"Network analysis reveals complex interactions in heat shock response in the malaria parasite","display_name":"Network analysis reveals complex interactions in heat shock response in the malaria parasite","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2025643987","doi":"https://doi.org/10.1109/bibm.2013.6732711","mag":"2025643987"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2013.6732711","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732711","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110291878","display_name":"Timothy Lilburn","orcid":null},"institutions":[{"id":"https://openalex.org/I118047749","display_name":"American Type Culture Collection","ror":"https://ror.org/03thhhv76","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I118047749"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy G. Lilburn","raw_affiliation_strings":["Department of Bacteriology, American Type Culture Collection, Manassas, VA, USA","Dept. of Bacteriology, American Type Culture Collection, Manassas, VA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, American Type Culture Collection, Manassas, VA, USA","institution_ids":["https://openalex.org/I118047749"]},{"raw_affiliation_string":"Dept. of Bacteriology, American Type Culture Collection, Manassas, VA, USA","institution_ids":["https://openalex.org/I118047749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018694636","display_name":"Hong Cai","orcid":"https://orcid.org/0000-0001-9699-7260"},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Cai","raw_affiliation_strings":["University of Texas at San Antonio, San Antonio, TX, US","Dept. of Biol., Univ. of Texas at San Antonio, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX, US","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Dept. of Biol., Univ. of Texas at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090573566","display_name":"Jianying Gu","orcid":"https://orcid.org/0000-0003-4972-8054"},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I142393192","display_name":"College of Staten Island","ror":"https://ror.org/02p179j44","country_code":"US","type":"education","lineage":["https://openalex.org/I142393192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianying Gu","raw_affiliation_strings":["Department of Biology, City University of New York, Staten Island, NY, USA","Dept. of Biol., City Univ. of New York, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, City University of New York, Staten Island, NY, USA","institution_ids":["https://openalex.org/I142393192","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Dept. of Biol., City Univ. of New York, New York, NY, USA","institution_ids":["https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076905288","display_name":"Zhan Zhou","orcid":"https://orcid.org/0000-0002-2730-5483"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhan Zhou","raw_affiliation_strings":["Department of Biology, University of Texas at San Antonio, San Antonio, TX, USA","Dept. of Biol., Univ. of Texas at San Antonio, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Texas at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204","https://openalex.org/I165951966"]},{"raw_affiliation_string":"Dept. of Biol., Univ. of Texas at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100367914","display_name":"Yufeng Wang","orcid":"https://orcid.org/0000-0002-4576-1984"},"institutions":[{"id":"https://openalex.org/I4210154757","display_name":"Texas Center for Infectious Disease","ror":"https://ror.org/04rtgz764","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210154757"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yufeng Wang","raw_affiliation_strings":["South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA","Dept. of Biol., Univ. of Texas at San Antonio, San Antonio, TX, USA"],"affiliations":[{"raw_affiliation_string":"South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I4210154757"]},{"raw_affiliation_string":"Dept. of Biol., Univ. of Texas at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5110291878"],"corresponding_institution_ids":["https://openalex.org/I118047749"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12839052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"11","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria","display_name":"Malaria","score":0.8799839615821838},{"id":"https://openalex.org/keywords/parasite-hosting","display_name":"Parasite hosting","score":0.7705497741699219},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.6986089944839478},{"id":"https://openalex.org/keywords/heat-shock-protein","display_name":"Heat shock protein","score":0.6147034764289856},{"id":"https://openalex.org/keywords/shock","display_name":"Shock (circulatory)","score":0.56581050157547},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.5547300577163696},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5024564266204834},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5003228187561035},{"id":"https://openalex.org/keywords/heat-shock","display_name":"Heat shock","score":0.45491647720336914},{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium (life cycle)","score":0.4444708228111267},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4213048815727234},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.37520018219947815},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20036399364471436},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.136173278093338},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.13367560505867004},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11794507503509521}],"concepts":[{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.8799839615821838},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.7705497741699219},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6986089944839478},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6147034764289856},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.56581050157547},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.5547300577163696},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5024564266204834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5003228187561035},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.45491647720336914},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.4444708228111267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4213048815727234},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37520018219947815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20036399364471436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.136173278093338},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13367560505867004},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11794507503509521},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2013.6732711","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732711","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1973872761","https://openalex.org/W1986640433","https://openalex.org/W2000706958","https://openalex.org/W2019851585","https://openalex.org/W2037173275","https://openalex.org/W2041687629","https://openalex.org/W2053315960","https://openalex.org/W2057498577","https://openalex.org/W2062905495","https://openalex.org/W2068961074","https://openalex.org/W2077191721","https://openalex.org/W2083193536","https://openalex.org/W2088709972","https://openalex.org/W2102155970","https://openalex.org/W2105924489","https://openalex.org/W2107328613","https://openalex.org/W2107644675","https://openalex.org/W2112047656","https://openalex.org/W2117484859","https://openalex.org/W2118360452","https://openalex.org/W2129895984","https://openalex.org/W2132632499","https://openalex.org/W2137015675","https://openalex.org/W2142365031","https://openalex.org/W2143861412","https://openalex.org/W2144656637","https://openalex.org/W2148621849","https://openalex.org/W2151383900","https://openalex.org/W2155142785","https://openalex.org/W2156022009","https://openalex.org/W2156522652","https://openalex.org/W2160795241","https://openalex.org/W2164365774","https://openalex.org/W2171030481","https://openalex.org/W4232483673"],"related_works":["https://openalex.org/W2084516783","https://openalex.org/W108401637","https://openalex.org/W2043005394","https://openalex.org/W4389493532","https://openalex.org/W2120900442","https://openalex.org/W2124445532","https://openalex.org/W2085889605","https://openalex.org/W2020103418","https://openalex.org/W2011687389","https://openalex.org/W2084664916"],"abstract_inverted_index":{"Malaria":[0],"is":[1],"a":[2,60],"serious":[3],"infectious":[4],"disease":[5],"that":[6,42],"affects":[7],"300\u2013500":[8],"million":[9],"people":[10],"in":[11,17,21,59,66],"the":[12,22],"world.":[13],"The":[14],"proteins":[15,47],"involved":[16],"heat":[18,45],"shock":[19,46],"response":[20],"malaria":[23],"parasite":[24,67],"Plasmodium":[25],"falciparum":[26],"have":[27],"long":[28],"been":[29],"considered":[30],"as":[31],"promising":[32],"vaccine":[33],"and":[34,70],"drug":[35],"targets.":[36],"Our":[37],"comprehensive":[38],"network":[39],"analysis":[40],"reveals":[41],"about":[43],"103":[44],"are":[48],"associated":[49],"with":[50],"over":[51],"900":[52],"other":[53],"proteins.":[54],"They":[55],"may":[56],"play":[57],"roles":[58],"wide":[61],"variety":[62],"of":[63],"cellular":[64],"processes":[65],"growth,":[68],"development,":[69],"pathogenesis.":[71]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}