{"id":"https://openalex.org/W2057330659","doi":"https://doi.org/10.1109/bibm.2013.6732690","title":"Deriving mutual modes from HPLC fingerprints of traditional Chinese medicine with non-negative matrix factorization","display_name":"Deriving mutual modes from HPLC fingerprints of traditional Chinese medicine with non-negative matrix factorization","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2057330659","doi":"https://doi.org/10.1109/bibm.2013.6732690","mag":"2057330659"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2013.6732690","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732690","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081941068","display_name":"Hang Wei","orcid":"https://orcid.org/0000-0002-0579-1716"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Wei","raw_affiliation_strings":["School of Computer & Engineering, South China University of Technology, Guangzhou, China","Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer & Engineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101483417","display_name":"Lin Li","orcid":"https://orcid.org/0000-0002-5207-5122"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Lin","raw_affiliation_strings":["School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China","School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]},{"raw_affiliation_string":"School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055682121","display_name":"Qinqun Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin-qun Chen","raw_affiliation_strings":["School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China","Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]},{"raw_affiliation_string":"Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061315321","display_name":"Hong-Lai Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-lai Zhang","raw_affiliation_strings":["School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China","Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]},{"raw_affiliation_string":"Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075667023","display_name":"Shaodong Deng","orcid":"https://orcid.org/0000-0001-8155-7369"},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]},{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao-dong Deng","raw_affiliation_strings":["The Second Clinical College, Guangdong Medical College, Guangzhou, China","Second Clinical Coll., Guangdong Med. Coll., Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical College, Guangdong Medical College, Guangzhou, China","institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210090868","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Second Clinical Coll., Guangdong Med. Coll., Guangzhou, China","institution_ids":["https://openalex.org/I4210090868","https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082617228","display_name":"Cai-xia Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cai-xia Liang","raw_affiliation_strings":["School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China","Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]},{"raw_affiliation_string":"Sch. of Med. Inf. Eng., Guangzhou Univ. of Chinese Med., Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":null,"first_page":"265","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.7494570016860962},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.718599796295166},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6352198123931885},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.572421669960022},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5413375496864319},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5385512113571167},{"id":"https://openalex.org/keywords/mode","display_name":"Mode (computer interface)","score":0.500368595123291},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.4886937439441681},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.45549261569976807},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4212130308151245},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37840861082077026},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3590484857559204},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.18303734064102173}],"concepts":[{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.7494570016860962},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.718599796295166},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6352198123931885},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.572421669960022},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5413375496864319},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5385512113571167},{"id":"https://openalex.org/C48677424","wikidata":"https://www.wikidata.org/wiki/Q6888088","display_name":"Mode (computer interface)","level":2,"score":0.500368595123291},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.4886937439441681},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.45549261569976807},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4212130308151245},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37840861082077026},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3590484857559204},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.18303734064102173},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2013.6732690","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732690","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.5099999904632568}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W1997851541","https://openalex.org/W2023062008","https://openalex.org/W2092423825","https://openalex.org/W2113359929","https://openalex.org/W2120816706","https://openalex.org/W2135029798","https://openalex.org/W2142621404","https://openalex.org/W2152320972","https://openalex.org/W2152943451","https://openalex.org/W2241791199","https://openalex.org/W2347403821","https://openalex.org/W2354275380","https://openalex.org/W2368716251","https://openalex.org/W2369795068","https://openalex.org/W2392827636","https://openalex.org/W3143596294","https://openalex.org/W6680012447","https://openalex.org/W6708650279","https://openalex.org/W6996834184","https://openalex.org/W7056629585"],"related_works":["https://openalex.org/W2127243424","https://openalex.org/W2037504162","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2539013788","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W2075222291","https://openalex.org/W2146544734"],"abstract_inverted_index":{"Mutual":[0],"modes":[1],"derived":[2,183],"from":[3,34,60,135,163],"Chromatographic":[4,247],"fingerprints":[5,40,45,89,248,262],"of":[6,41,46,50,67,87,105,132,151,156,161,172,176,181,238,245,260,263],"high-quality":[7],"traditional":[8],"Chinese":[9],"medicine":[10],"(TCM)":[11],"can":[12,71,189,250],"provide":[13,251],"standards":[14],"for":[15,108,148],"quality":[16],"assessment.":[17],"This":[18],"paper":[19],"demonstrates":[20],"a":[21,235],"new":[22],"method":[23,188,233],"to":[24,77,94,168,212,224,255],"apply":[25],"non-negative":[26],"matrix":[27],"factorization":[28],"(NMF)":[29],"in":[30,57,102,137],"deriving":[31],"mutual":[32,85,149,174,179,215,258],"mode":[33,86,150,175,180,216],"high":[35],"performance":[36],"liquid":[37],"chromatography":[38],"(HPLC)":[39],"TCM.":[42,264],"The":[43,178,227],"HPLC":[44,88,261],"the":[47,68,79,84,103,145,170,173,185,191,195,198,206,209,213,231,242,257],"same":[48],"species":[49,106,223],"TCM":[51],"are":[52,217],"taken":[53],"as":[54,144],"data":[55,70,147,243],"set":[56],"NMF":[58],"analysis,":[59],"which":[61,112],"feature":[62,81],"bases":[63],"containing":[64],"global":[65],"features":[66],"original":[69,146,246],"be":[72],"extracted.":[73],"Reconstruction":[74],"is":[75,90],"performed":[76],"utilizing":[78],"first":[80],"base":[82],"and":[83,123,158,240,249],"obtained":[91],"by":[92,184],"projecting":[93],"basis":[95],"matrix.":[96],"Satisfactory":[97],"results":[98,211],"have":[99],"been":[100],"achieved":[101],"experiment":[104],"identification":[107],"Exocarpium":[109],"Citrus":[110],"Grandis,":[111],"has":[113,234],"two":[114],"primary":[115],"species,":[116],"that":[117,230],"is,":[118],"Citius":[119,124],"Grandis":[120,125],"`Tomentosa'":[121],"(CGT)":[122],"(L.)":[126],"Osbeck":[127],"(CGO).":[128],"Forty-seven":[129],"representative":[130,200],"batches":[131,155,160],"CGT":[133,157,182],"collected":[134],"GAP":[136],"Huazhou":[138],"(Guangdong":[139],"Province,":[140],"China),":[141],"were":[142,166,202],"served":[143],"CGT.":[152,177],"Furthermore,":[153],"six":[154,159],"CGO":[162],"different":[164,222],"places":[165],"utilized":[167],"test":[169],"effectiveness":[171],"proposed":[186,214],"NMF-based":[187,232],"cover":[190],"basic":[192],"information":[193,244],"on":[194],"whole,":[196],"since":[197],"main":[199],"peaks":[201],"contained.":[203],"Compared":[204],"with":[205],"existing":[207],"approaches,":[208],"similarity":[210],"more":[218],"clearly":[219],"distinguished":[220],"among":[221],"some":[225],"extent.":[226],"research":[228],"indicates":[229],"better":[236],"capability":[237],"maintaining":[239],"summarizing":[241],"an":[252],"effective":[253],"approach":[254],"establish":[256],"model":[259]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}