{"id":"https://openalex.org/W2024220621","doi":"https://doi.org/10.1109/bibm.2013.6732599","title":"Profiling adverse drug events of cancer drug ingredients using normalized AERS data","display_name":"Profiling adverse drug events of cancer drug ingredients using normalized AERS data","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2024220621","doi":"https://doi.org/10.1109/bibm.2013.6732599","mag":"2024220621"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2013.6732599","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732599","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100406712","display_name":"Liwei Wang","orcid":"https://orcid.org/0000-0003-0782-7302"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liwei Wang","raw_affiliation_strings":["Jilin University, Changchun, Jilin, CN","Dept. of Med. Inf., Jilin Univ., Changchun, China"],"affiliations":[{"raw_affiliation_string":"Jilin University, Changchun, Jilin, CN","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Dept. of Med. Inf., Jilin Univ., Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101585391","display_name":"Hongfang Liu","orcid":"https://orcid.org/0000-0003-2570-3741"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongfang Liu","raw_affiliation_strings":["Department of Health Science Research, Mayo Clinic, Rochester, USA","Dept. of Health Sci. Res., Mayo Clinic, Rochester, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Health Science Research, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Dept. of Health Sci. Res., Mayo Clinic, Rochester, NY, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100406712"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0714058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"46","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7505000829696655},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.7009643912315369},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.5848698616027832},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5646942257881165},{"id":"https://openalex.org/keywords/adverse-event-reporting-system","display_name":"Adverse Event Reporting System","score":0.4974537193775177},{"id":"https://openalex.org/keywords/drug-reaction","display_name":"Drug reaction","score":0.41558337211608887},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3819581866264343},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35476768016815186},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3272096514701843},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.23723116517066956},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08759653568267822}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7505000829696655},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.7009643912315369},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5848698616027832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5646942257881165},{"id":"https://openalex.org/C2777105317","wikidata":"https://www.wikidata.org/wiki/Q4686710","display_name":"Adverse Event Reporting System","level":3,"score":0.4974537193775177},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.41558337211608887},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3819581866264343},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35476768016815186},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3272096514701843},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23723116517066956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08759653568267822},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2013.6732599","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2013.6732599","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W43369243","https://openalex.org/W113750267","https://openalex.org/W1513396334","https://openalex.org/W1971980459","https://openalex.org/W1996239270","https://openalex.org/W1999506291","https://openalex.org/W2045409256","https://openalex.org/W2057975842","https://openalex.org/W2074289946","https://openalex.org/W2081459939","https://openalex.org/W2084769502","https://openalex.org/W2103559160","https://openalex.org/W2109733561","https://openalex.org/W2109906713","https://openalex.org/W2112870137","https://openalex.org/W2114470427","https://openalex.org/W2139585168","https://openalex.org/W2167352770","https://openalex.org/W2339454388","https://openalex.org/W2415027469","https://openalex.org/W2416246916","https://openalex.org/W4320300890","https://openalex.org/W6604626259","https://openalex.org/W6716168938"],"related_works":["https://openalex.org/W1669499790","https://openalex.org/W4282838629","https://openalex.org/W1967736925","https://openalex.org/W4281861147","https://openalex.org/W4391172823","https://openalex.org/W4388132138","https://openalex.org/W2342267228","https://openalex.org/W3011938841","https://openalex.org/W2918034594","https://openalex.org/W4280493563"],"abstract_inverted_index":{"To":[0],"facilitate":[1],"the":[2,34,48,88,127,133],"utilization":[3],"of":[4,38,59,61,90,135,143],"FDA's":[5],"adverse":[6,53],"event":[7],"reporting":[8],"system":[9],"(AERS)":[10],"for":[11,100,117,122,140],"data":[12,21,24,35,138],"mining,":[13],"we":[14,30],"previously":[15],"normalized":[16],"AERS":[17],"and":[18,57,67,70,73,95],"aggregated":[19],"related":[20],"into":[22],"a":[23,83],"set":[25],"(AERS-DM).":[26],"In":[27,92,125],"this":[28,130],"paper,":[29],"aim":[31],"to":[32,86],"demonstrate":[33],"mining":[36,139],"potential":[37,134],"AERS-DM":[39,136],"by":[40],"profiling":[41,141],"cancer":[42,62,144],"drug":[43,54,63,119,145],"ingredients.":[44,146],"Findings":[45],"suggest":[46],"that":[47,78],"co-relationship":[49,80],"may":[50,81,112],"exist":[51],"between":[52,65,71],"events":[55],"(ADEs)":[56],"mechanism":[58],"action":[60],"ingredients,":[64],"ADEs":[66,72,99,142],"physiologic":[68],"effect,":[69],"treatment":[74],"intention.":[75],"We":[76],"speculate":[77],"such":[79],"provide":[82],"new":[84],"direction":[85],"explore":[87],"etiology":[89],"ADEs.":[91],"addition,":[93],"age":[94],"sex":[96],"differences":[97],"in":[98,129,137],"those":[101],"ingredients":[102],"are":[103],"revealed,":[104],"among":[105],"them":[106],"what":[107],"haven't":[108],"been":[109],"discovered":[110],"before":[111],"be":[113],"used":[114],"as":[115],"hypotheses":[116],"detecting":[118],"safety":[120],"signal":[121],"further":[123],"investigations.":[124],"conclusion,":[126],"discoveries":[128],"study":[131],"show":[132]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}