{"id":"https://openalex.org/W2128917161","doi":"https://doi.org/10.1109/bibm.2012.6392727","title":"Accurate detection of SNPs using base-specific cleavage and mass spectrometry","display_name":"Accurate detection of SNPs using base-specific cleavage and mass spectrometry","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2128917161","doi":"https://doi.org/10.1109/bibm.2012.6392727","mag":"2128917161"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2012.6392727","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392727","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102427520","display_name":"Ruimin Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Ruimin Sun","raw_affiliation_strings":["School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","School of Physical and Mathematical Sciences Nanyang Technological University"],"affiliations":[{"raw_affiliation_string":"School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Physical and Mathematical Sciences Nanyang Technological University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086043105","display_name":"Xiang Gao","orcid":"https://orcid.org/0000-0002-5695-3578"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xiang Gao","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore","School of Biological Sciences, Nanyang Technological University#TAB#"],"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University#TAB#","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046614068","display_name":"Nanyu Han","orcid":"https://orcid.org/0000-0002-9789-1596"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nanyu Han","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore","School of Biological Sciences, Nanyang Technological University#TAB#"],"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University#TAB#","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103133463","display_name":"Qiong Wu","orcid":"https://orcid.org/0009-0004-5316-7266"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Qiong Wu","raw_affiliation_strings":["School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","School of Physical and Mathematical Sciences Nanyang Technological University"],"affiliations":[{"raw_affiliation_string":"School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Physical and Mathematical Sciences Nanyang Technological University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071286986","display_name":"Yuguang Mu","orcid":"https://orcid.org/0000-0002-2499-026X"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yuguang Mu","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore","School of Biological Sciences, Nanyang Technological University#TAB#"],"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University#TAB#","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015413405","display_name":"Kai Tang","orcid":"https://orcid.org/0000-0003-3913-6426"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kai Tang","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, Singapore","School of Biological Sciences, Nanyang Technological University#TAB#"],"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University#TAB#","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100363078","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-5189-5647"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","School of Physical and Mathematical Sciences Nanyang Technological University"],"affiliations":[{"raw_affiliation_string":"School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Physical and Mathematical Sciences Nanyang Technological University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5102427520"],"corresponding_institution_ids":["https://openalex.org/I172675005"],"apc_list":null,"apc_paid":null,"fwci":0.1577,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51544214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.6663326621055603},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6249688267707825},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.5117321014404297},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5101907253265381},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47363582253456116},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32050347328186035},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29812926054000854},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.24265560507774353},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2381013035774231},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2097117304801941},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.12839895486831665},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10086360573768616}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6663326621055603},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6249688267707825},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5117321014404297},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5101907253265381},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47363582253456116},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32050347328186035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29812926054000854},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.24265560507774353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2381013035774231},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2097117304801941},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12839895486831665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10086360573768616}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm.2012.6392727","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2012.6392727","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Bioinformatics and Biomedicine","raw_type":"proceedings-article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/102864","is_oa":false,"landing_page_url":"https://hdl.handle.net/10356/102864","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321026","display_name":"Ministry of Earth Sciences","ror":"https://ror.org/013cf5k59"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2010296522","https://openalex.org/W2025888918","https://openalex.org/W2029047779","https://openalex.org/W2079353636","https://openalex.org/W2139476567"],"related_works":["https://openalex.org/W1997352593","https://openalex.org/W2143489661","https://openalex.org/W3016573916","https://openalex.org/W4281711902","https://openalex.org/W3206555169","https://openalex.org/W2070581548","https://openalex.org/W3157359833","https://openalex.org/W2413660786","https://openalex.org/W3024317680","https://openalex.org/W1511048503"],"abstract_inverted_index":{"Accurate":[0],"detection":[1,34,64],"of":[2,11,41,75,115],"single-nucleotide":[3],"polymorphisms":[4],"(SNPs)":[5],"is":[6,35],"crucial":[7],"for":[8,32],"the":[9,38,76,112],"success":[10],"many":[12,27],"downstream":[13],"analyses":[14],"such":[15],"as":[16,117],"clinical":[17],"diagnosis,":[18],"virus":[19],"identification,":[20],"genetic":[21],"mapping":[22],"and":[23,72,103],"association":[24],"studies.":[25],"Among":[26],"others,":[28],"one":[29],"valuable":[30],"approach":[31],"SNP":[33,63],"based":[36],"on":[37,100],"base-specific":[39,81],"cleavage":[40],"single-stranded":[42],"nucleic":[43],"acids":[44],"followed":[45],"by":[46],"matrix-assisted":[47],"laser":[48],"desorption/ionization":[49],"time-of-flight":[50],"mass":[51,82],"spectrometry":[52],"(MALDI-TOF":[53],"MS)":[54],"analysis.":[55],"In":[56],"this":[57],"paper,":[58],"we":[59],"present":[60],"a":[61,90,118],"new":[62,85],"algorithm,":[65],"which":[66],"in":[67,78,89],"particular":[68],"permits":[69],"an":[70],"efficient":[71],"effective":[73],"integration":[74],"information":[77],"four":[79],"complementary":[80],"spectra.":[83],"The":[84],"algorithm":[86],"was":[87],"implemented":[88],"program":[91],"called":[92],"SnpMs.":[93],"Comparative":[94],"evaluation":[95],"has":[96],"been":[97],"carried":[98],"out":[99],"both":[101],"simulated":[102],"real":[104],"biological":[105],"datasets,":[106],"where":[107],"experimental":[108],"results":[109],"clearly":[110],"demonstrated":[111],"high":[113],"ability":[114],"SnpMs":[116],"tool":[119],"to":[120],"accurately":[121],"detect":[122],"SNPs.":[123]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
